IP Library Granted Patent US 12,508,351
Granted Patent B2
US 12,508,351 · App. 18/298,810 · Granted Dec 30, 2025

Extracorporeal blood filtering machine and methods

Inventors: Vitaliy Gennad'yevich Epshteyn (Maple Grove, MN); Steven Daniel Sandoval (Eden Prairie, MN); Kalley Francis Berg (Lino Lakes, MN); Franz Willems Ulrich (Minneapolis, MN)
Assignee: NUWELLIS, INC.
A61M1/154A61M1/1601A61M1/36224A61J1/10A61M1/14A61M1/155A61M1/1562A61M1/15632A61M1/1566A61M1/16A61M1/1643A61M1/1694A61M1/34A61M1/3403A61M1/341A61M1/3413A61M1/342A61M1/3424A61M1/3427A61M1/3431A61M1/3434A61M1/3437A61M1/3441A61M1/3444A61M1/3451A61M1/3607A61M1/361A61M1/36225A61M1/362262A61M1/362264A61M1/362266A61M1/3624A61M1/3626A61M1/3627A61M1/3639A61M1/3644A61M1/3663A61M1/3672A61M5/1415A61M5/165A61M5/172A61M60/109A61M60/268A61M2202/0042A61M2205/3331A61M2205/3368A61M2205/3379A61M2205/3393A61M2205/50A61M2205/502A61M2205/505A61M2205/82A61M2205/8206A61M2205/8262A61M2230/005
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,508,351
App. No.
18/298,810
Granted
Dec 30, 2025
Kind
B2
Abstract

An extracorporeal blood filtering machine can include a blood circuit, an effluent circuit, and a source fluid circuit and can be controlled by a controller. The extracorporeal blood filtering machine can also include access ports for connecting the source fluid circuit to the blood circuit, as well as blood sensors to detect possible issues with the extracorporeal blood filtering machine. The extracorporeal blood filtering machine can include density sensors and flow sensors that enable it to be more accurate and to operate while being transported. The extracorporeal blood filtering machine can further include a user interface and can display fluid inflow/outflow information. A medical fluid container can automatically empty after being filled. An apparatus for supporting a medical fluid container can include a hanger and an attachment member with the apparatus able to adjust to ensure the medical fluid container remains properly oriented directly under a medical fluid container scale.

Claims (50)

1 . An extracorporeal blood filtering machine comprising:

a blood circuit that includes:

a blood line comprising a blood inlet configured to receive blood from a patient and a blood outlet configured to return the blood to the patient,

a filter fluidly connected to the blood line between the blood inlet and the blood outlet, and

a blood pump configured to pump the blood from the blood inlet to the blood outlet through the filter, the filter configured to remove waste from the blood;

a clamp configured to engage the blood line and to move between a clamp-open position in which the blood line is open for blood to return to the patient through the blood outlet and a clamp-closed position in which the blood line is closed off and blood is prevented from returning to the patient through the blood outlet, the clamp configured to impart a predetermined clamping force on the blood line when in the clamp-closed position;

a temperature sensor configured to measure an ambient air temperature and/or a temperature of the blood line; and

a controller in communication with the blood pump and the clamp, the controller configured to:

receive the ambient air temperature and/or the blood line temperature from the temperature sensor, and

adjust the predetermined clamping force of the clamp on the blood line based on the received ambient air temperature and/or blood line temperature, the controller configured to increase the predetermined clamping force when the ambient air temperature and/or the blood line temperature is below a first threshold, or decrease the predetermined clamping force when the ambient air temperature and/or the blood line temperature is above a second threshold.

2 . The extracorporeal blood filtering machine of claim 1 , wherein the controller is configured to increase the predetermined clamping force when the ambient air temperature and/or the blood line temperature is below a first threshold, and to decrease the predetermined clamping force when the ambient air temperature and/or the blood line temperature is above a second threshold.

3 . The extracorporeal blood filtering machine of claim 1 , wherein the controller is configured to adjust the operation of the clamp by causing the clamp to move from the clamp-open position to the clamp-closed position and back to the clamp-open position if the ambient air temperature and/or the blood line temperature is below a third threshold.

4 . The extracorporeal blood filtering machine of claim 3 , wherein the controller is configured to pause the blood pump when the clamp is in the clamp-closed position.

5 . The extracorporeal blood filtering machine of claim 3 , wherein the controller is configured to periodically repeat causing the clamp to move from the clamp-open position to the clamp-closed position and back to the clamp-open position if the ambient air temperature and/or the blood line temperature is below the third threshold.

6 . The extracorporeal blood filtering machine of claim 1 , wherein the blood line temperature comprises a temperature of an exterior of the blood line.

7 . The extracorporeal blood filtering machine of claim 1 , wherein the controller is further configured to initiate an alarm mode in which the controller controls the clamp to move from the clamp-open position to the clamp-closed position.

8 . The extracorporeal blood filtering machine of claim 7 , wherein the controller is configured to identify an alarm condition and initiate the alarm mode.

9 . The extracorporeal blood filtering machine of claim 7 , wherein the controller is configured to receive an alarm signal and initiate the alarm mode.

10 . The extracorporeal blood filtering machine of claim 7 , further comprising an air bubble sensor configured to identify an air bubble in the blood line and send an air bubble signal to the controller, wherein the controller is configured to receive the air bubble signal and initiate the alarm mode.

11 . The extracorporeal blood filtering machine of claim 1 , wherein the blood line includes thermal insulation bonded to where the clamp engages the blood line.

12 . A method comprising:

providing an extracorporeal blood filtering machine that comprises:

a blood circuit that includes:

a blood line comprising a blood inlet and a blood outlet,

a filter fluidly connected to the blood line between the blood inlet and the blood outlet, and

a blood pump;

a clamp engaged with the blood line;

a temperature sensor; and

a controller in communication with the blood pump and the clamp;

operating the extracorporeal blood filtering machine by the controller causing the blood pump to pump blood from a patient through the blood inlet into the filter and out through the blood outlet back to the patient;

measuring an ambient air temperature and/or a temperature of the blood line with the temperature sensor, and providing the ambient air temperature and/or the temperature of the blood line to the controller; and

adjusting by the controller a predetermined clamping force the clamp imparts to the blood line to prevent blood from returning to the patient through the blood outlet based on the received ambient air temperature and/or blood line temperature, wherein adjusting the predetermined clamping force comprises increasing the predetermined clamping force by the controller when the ambient air temperature and/or the blood line temperature is below a first threshold, or decreasing the predetermined clamping force by the controller when the ambient air temperature and/or the blood line temperature is above a second threshold.

13 . The method of claim 12 , wherein adjusting the predetermined clamping force of the clamp comprises causing the clamp to impart an intermittent reconditioning force on the blood line by the controller.

14 . The method of claim 13 , wherein the intermittent reconditioning force is imparted on the blood line by the controller when the ambient air temperature and/or the blood line temperature is below a third threshold.

15 . The method of claim 12 , wherein measuring the ambient air temperature and/or the temperature of the blood line with the temperature sensor comprises measuring an exterior temperature of the blood line.

16 . An extracorporeal blood filtering machine comprising:

a blood circuit that includes:

a blood line comprising a blood inlet configured to receive blood from a patient and a blood outlet configured to return the blood to the patient,

a filter fluidly connected to the blood line between the blood inlet and the blood outlet, and

a blood pump configured to pump the blood from the blood inlet to the blood outlet through the filter, the filter configured to remove waste from the blood;

a clamp configured to engage the blood line and to move between a clamp-open position in which the blood line is open for blood to return to the patient through the blood outlet and a clamp-closed position in which the blood line is closed off and blood is prevented from returning to the patient through the blood outlet, the clamp configured to impart a predetermined clamping force on the blood line when in the clamp-closed position;

a thermal insulation bonded to the blood line where the clamp engages the blood line;

a temperature sensor configured to measure an ambient air temperature and/or a temperature of the blood line; and

a controller in communication with the blood pump and the clamp, the controller configured to:

receive the ambient air temperature and/or the blood line temperature from the temperature sensor, and

adjust an operation of the clamp based on the received ambient air temperature and/or blood line temperature.

17 . The extracorporeal blood filtering machine of claim 16 , wherein the controller is configured to adjust the predetermined clamping force imparted on the blood line by the clamp based on the ambient air temperature and/or the temperature of the blood line received by the temperature sensor.

18 . The extracorporeal blood filtering machine of claim 17 , wherein adjusting the predetermined clamping force comprises increasing the predetermined clamping force by the controller when the ambient air temperature and/or the blood line temperature is below a first threshold.

19 . The extracorporeal blood filtering machine of claim 17 , wherein adjusting the predetermined clamping force comprises decreasing the predetermined clamping force by the controller when the ambient air temperature and/or the blood line temperature is above a second threshold.

20 . The extracorporeal blood filtering machine of claim 16 , wherein the controller is further configured to initiate an alarm mode in which the controller controls the clamp to move from the clamp-open position to the clamp-closed position.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 6, 2023
From: EPSHTEYN, VITALIY GENNAD'YEVICH; SANDOVAL, STEVEN DANIEL; BERG, KALLEY FRANCIS; ULRICH, FRANZ WILLEMS
To: NUWELLIS, INC.
Reel/Frame 063863/0857 →
Continuity (2)
Continuation 18171612 · Feb 20, 2023
Related Publication 20240277930A1 · Aug 22, 2024
References Cited (113)
US 4670007A · Wheeldon et al. · 1987 [cited by applicant]
US 4728433A · Buck et al. · 1988 [cited by applicant]
US 4850560A · Ross · 1989 [cited by applicant]
US 5211849A · Kitaevich et al. · 1993 [cited by applicant]
US 6200485B1 · Kitaevich et al. · 2001 [cited by applicant]
US 6302864B1 · Nowosielski · 2001 [cited by applicant]
US 6468241B1 · Gelfand et al. · 2002 [cited by applicant]
US 6585675B1 · O'Mahony et al. · 2003 [cited by applicant]
US 6685664B2 · Levin et al. · 2004 [cited by applicant]
US 6695806B2 · Gelfand et al. · 2004 [cited by applicant]
US 6773412B2 · O'Mahony et al. · 2004 [cited by applicant]
US 6796955B2 · O'Mahony et al. · 2004 [cited by applicant]
US 6887214B1 · Evin et al. · 2005 [cited by applicant]
US 6890315B1 · Levin et al. · 2005 [cited by applicant]
US 6923782B2 · O'Mahony et al. · 2005 [cited by applicant]
US 6947131B2 · O'Mahony et al. · 2005 [cited by applicant]
US RE38869E · Polaschegg et al. · 2005 [cited by applicant]
US 7018182B2 · O'Mahony et al. · 2006 [cited by applicant]
US 7135008B2 · O'Mahony et al. · 2006 [cited by applicant]
US 7199312B2 · O'Mahony et al. · 2007 [cited by applicant]
US 7230687B2 · O'Mahony et al. · 2007 [cited by applicant]
US 7232418B2 · Neri et al. · 2007 [cited by applicant]
US 7297270B2 · Bernard et al. · 2007 [cited by applicant]
US 7303540B2 · O'Mahony et al. · 2007 [cited by applicant]
US 7311689B2 · Levin et al. · 2007 [cited by applicant]
US 7314554B2 · Delnevo et al. · 2008 [cited by applicant]
US 7410473B2 · Levin et al. · 2008 [cited by applicant]
US 7410582B2 · Bernard et al. · 2008 [cited by applicant]
US 7462786B2 · O'Mahony et al. · 2008 [cited by applicant]
US 7547200B2 · O'Mahony et al. · 2009 [cited by applicant]
US 7585286B2 · O'Mahony et al. · 2009 [cited by applicant]
US 7647834B2 · O'Mahony et al. · 2010 [cited by applicant]
US 7727391B2 · Delnevo et al. · 2010 [cited by applicant]
US 7789850B2 · Roger · 2010 [cited by applicant]
US 7867393B2 · Duchamp et al. · 2011 [cited by applicant]
US 7886611B2 · O'Mahony et al. · 2011 [cited by applicant]
US 7906737B2 · Freydank et al. · 2011 [cited by applicant]
US 7935071B2 · Levin et al. · 2011 [cited by applicant]
US 8197432B2 · O'Mahony et al. · 2012 [cited by applicant]
US 8267308B2 · Devergne et al. · 2012 [cited by applicant]
US 8267881B2 · O'Mahony et al. · 2012 [cited by applicant]
US 8361023B2 · Bedingfield · 2013 [cited by applicant]
US 8459543B2 · Devergne et al. · 2013 [cited by applicant]
US 8562822B2 · Roger et al. · 2013 [cited by applicant]
US 8562823B2 · Roger et al. · 2013 [cited by applicant]
US 8603021B2 · Levin et al. · 2013 [cited by applicant]
US 8608953B2 · Brotherton et al. · 2013 [cited by applicant]
US 8702638B2 · O'Mahony et al. · 2014 [cited by applicant]
US 9089639B2 · Breuel et al. · 2015 [cited by applicant]
US 9138526B2 · Ware et al. · 2015 [cited by applicant]
US 9999716B2 · Golarits et al. · 2018 [cited by applicant]
US 10549023B2 · Updyke et al. · 2020 [cited by applicant]
US 10603423B2 · Childers et al. · 2020 [cited by applicant]
US 10695481B2 · Kelly et al. · 2020 [cited by applicant]
US 10881347B2 · Barrett et al. · 2021 [cited by applicant]
US 10987461B2 · Brugger et al. · 2021 [cited by applicant]
US 11105669B2 · Evans et al. · 2021 [cited by applicant]
US 11273246B2 · Plahey · 2022 [cited by applicant]
US 11351291B2 · Kreymann et al. · 2022 [cited by applicant]
US 11386994B2 · Handler · 2022 [cited by applicant]
US 11524101B2 · Golarits et al. · 2022 [cited by applicant]
US 20050251086A1 · Sternby · 2005 [cited by applicant]
US 20050284815A1 · Sparks et al. · 2005 [cited by applicant]
US 20070031976A1 · Trouilly et al. · 2007 [cited by applicant]
US 20070265594A1 · Hagermark et al. · 2007 [cited by applicant]
US 20080004594A1 · Pahlberg et al. · 2008 [cited by applicant]
US 20080015487A1 · Szamosfalvi et al. · 2008 [cited by applicant]
US 20100022934A1 · Hogard · 2010 [cited by examiner]
US 20100038317A1 · Bissler et al. · 2010 [cited by applicant]
US 20100089806A1 · Peters et al. · 2010 [cited by applicant]
US 20100121246A1 · Peters et al. · 2010 [cited by applicant]
US 20100264086A1 · Noack et al. · 2010 [cited by applicant]
US 20110056897A1 · Kao · 2011 [cited by applicant]
US 20110189048A1 · Curtis et al. · 2011 [cited by applicant]
US 20130012861A1 · Zhang · 2013 [cited by examiner]
US 20130199998A1 · Kelly et al. · 2013 [cited by applicant]
US 20150238676A1 · Giordano · 2015 [cited by examiner]
US 20160287779A1 · Orczy-Timko et al. · 2016 [cited by applicant]
US 20160354528A1 · Pouchoulin · 2016 [cited by applicant]
US 20180361046A1 · Moretti et al. · 2018 [cited by applicant]
US 20200353140A1 · Beden et al. · 2020 [cited by applicant]
US 20210030937A1 · Kelly et al. · 2021 [cited by applicant]
US 20210030938A1 · Kopperschmidt et al. · 2021 [cited by applicant]
US 20210046235A1 · Klewinghaus · 2021 [cited by applicant]
US 20210113753A1 · Moghaddam · 2021 [cited by applicant]
US 20210128806A1 · Mitrovic et al. · 2021 [cited by applicant]
US 20210128812A1 · Desouza et al. · 2021 [cited by applicant]
US 20210170084A1 · Zacharia et al. · 2021 [cited by applicant]
US 20210196880A1 · O'Mahony et al. · 2021 [cited by applicant]
US 20220054724A1 · Askenazi et al. · 2022 [cited by applicant]
US 20220080091A1 · Plahey · 2022 [cited by applicant]
US 20220080093A1 · Kogan · 2022 [cited by applicant]
US 20220211926A1 · Childers et al. · 2022 [cited by applicant]
US 20220241477A1 · Gura · 2022 [cited by applicant]
CN 108325019A · 2018 [cited by applicant]
CN 110152086A · 2019 [cited by applicant]
EP 611227A1 · 1994 [cited by applicant]
WO 2004069299A2 · 2004 [cited by applicant]
WO 20090146913A2 · 2009 [cited by applicant]
WO 2020132686A1 · 2020 [cited by applicant]
WO 2021089689A1 · 2021 [cited by applicant]
WO 2021089690A1 · 2021 [cited by applicant]
WO 2021094294A1 · 2021 [cited by applicant]
WO 2021094357A1 · 2021 [cited by applicant]
WO 2021094446A1 · 2021 [cited by applicant]
WO 2021219792A1 · 2021 [cited by applicant]
WO 2022096389A1 · 2022 [cited by applicant]
WO 2022167394A1 · 2022 [cited by applicant]
WO 2022171728A1 · 2022 [cited by applicant]
Prismax Manual (Baxter) https://usrenalacute.baxter.com/sites/g/files/ebysai3231/files/2020-12/Prismax%20Operator%27s%20Manual.pdf Dated Jun. 2019. [cited by applicant]
Medtronic “Small Patients. Small Solutions. Big Results. Carpediem cardio-renal pediatric dialysis emergency machine” , Brochure dated Aug. 2021, 9 pgs. [cited by applicant]
Medtronic “Technical Data Sheet BL 250 complete kit for hemofiltration/hemodialysis 015 and 0258 with the CARPEDIEM cardio-renal pediatric dialysis emergency machine” , dated Jun. 2021, 4 pgs. [cited by applicant]
International Search Report and Written Opinion of the International Application No. PCT/US2023/071577, mailed Nov. 22, 2023, 22 pg. [cited by applicant]