IP Library › Granted Patent US 12,551,343
Granted Patent B2
US 12,551,343 · App. 18/303,555 · Granted Feb 17, 2026

Techniques for fluoroscopic cardiac measurement

Inventor: Tal Reich (Moledet, IL)
Assignee: Edwards Lifesciences Innovation (Israel) Ltd.
A61F2/2457A61B5/1076A61F2/2466A61B2017/00243A61B2090/061A61B2090/376A61B2090/3966A61F2/2496A61F2220/0016A61F2250/0098
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Quick Facts
Patent No.
US 12,551,343
App. No.
18/303,555
Granted
Feb 17, 2026
Kind
B2
Abstract

A method is described, for use with a native valve of a heart of a subject, the valve being disposed between an atrium and a ventricle of the heart. A first radiopaque marker and a second radiopaque marker are percutaneously advanced to the heart. The first radiopaque marker is placed against a tissue site in the ventricle. The second radiopaque marker is placed against a component of the valve. A distance is fluoroscopically measured between the first radiopaque marker at the tissue site, and the second radiopaque marker at the component. At least one of the radiopaque markers is then withdrawn from the heart. Other embodiments are also described.

Claims (72)

1 . A method, comprising:

advancing a first radiopaque marker and a second radiopaque marker through vasculature to a heart, the first radiopaque marker being disposed on an elongate tool, and the heart having a native valve disposed between an atrium and a ventricle;

placing the tool in the ventricle such that the first radiopaque marker is disposed against a tissue site in the ventricle;

placing the second radiopaque marker against a component of the native valve;

fluoroscopically measuring a distance between the first radiopaque marker at the tissue site, and the second radiopaque marker at the component;

determining a chord-length responsively to the measured distance;

responsively to the chord-length, implanting an artificial chord in the heart by:

anchoring a tissue anchor that is coupled to a first end portion of the artificial chord to the tissue site while the elongate tool remains in the ventricle, and

attaching a second end portion of the artificial chord to the component of the native valve; and

subsequently, withdrawing from the heart at least one marker selected from the group consisting of:

the first radiopaque marker, and

the second radiopaque marker.

2 . The method according to claim 1 , wherein the selected marker is the second radiopaque marker, and wherein the step of withdrawing comprises withdrawing the second radiopaque marker from the heart.

3 . The method according to claim 1 , wherein the selected marker is the first radiopaque marker, and wherein the step of withdrawing comprises withdrawing the first radiopaque marker from the heart.

4 . The method according to claim 1 , wherein the step of withdrawing comprises withdrawing the first radiopaque marker and the second radiopaque marker from the heart.

5 . The method according to claim 1 , wherein:

the vasculature is a physical model of vasculature, and the heart is a physical model of a heart; and

the step of advancing comprises advancing the first radiopaque marker and the second radiopaque marker along the physical model of the vasculature to the physical model of the heart.

6 . The method according to claim 1 , wherein placing the first radiopaque marker against the tissue site comprises placing the first radiopaque marker against the tissue site under echocardiographic guidance, and placing the second radiopaque marker against the component comprises placing the second radiopaque marker against the component under echocardiographic guidance.

7 . The method according to claim 1 , wherein the component is a first leaflet of the valve, and wherein placing the second radiopaque marker against the component comprises placing the second radiopaque marker at a coaptation level between the first leaflet and a second leaflet of the valve.

8 . The method according to claim 1 , wherein the tissue site is on a papillary muscle, and wherein placing the first radiopaque marker against the tissue site comprises placing the first radiopaque marker against the papillary muscle.

9 . The method according to claim 1 :

further comprising, prior to the step of implanting, responsively to the chord-length, selecting an artificial chord from a selection of chords that includes at least one chord that does not have the chord-length; and

wherein the step of implanting comprises implanting the selected artificial chord in the heart by:

anchoring a tissue anchor that is coupled to a first end portion of the artificial chord to the tissue site without removing the elongate tool from the tissue site, and

attaching a second end portion of the artificial chord to the component of the native valve.

10 . The method according to claim 1 , further comprising, based on the chord-length, adjusting an artificial chord to the chord-length.

11 . The method according to claim 1 , wherein:

the component is a first leaflet of the native valve,

the artificial chord is a first artificial chord,

implanting the first artificial chord in the heart comprises:

anchoring a tissue anchor that is coupled to a first end portion of the first artificial chord to the tissue site without removing the elongate tool from the tissue site, and

attaching a second end portion of the first artificial chord to the first leaflet, and the method further comprises implanting a second artificial chord by attaching a second end portion of the second artificial chord to a second leaflet of the native valve.

12 . The method according to claim 11 , wherein implanting the second artificial chord comprises attaching a first end portion of the second artificial chord to a second tissue site in the ventricle.

13 . A method, comprising:

advancing a first radiopaque marker and a second radiopaque marker through vasculature to a heart, the heart having a native valve disposed between an atrium and a ventricle;

placing the first radiopaque marker against a tissue site in the ventricle;

placing the second radiopaque marker against a component of the native valve;

fluoroscopically measuring a distance between the first radiopaque marker at the tissue site, and the second radiopaque marker at the component;

determining a chord-length responsively to the measured distance; and

responsively to the chord-length, implanting an artificial chord in the heart by:

attaching a first end portion of an artificial chord to the tissue site, and

attaching a second end portion of the artificial chord to the component of the native valve.

14 . The method according to claim 13 , wherein attaching the second end portion comprises attaching the second end portion of the artificial chord to the component while at least one of the first radiopaque marker and the second radiopaque marker remains in the heart.

15 . The method according to claim 13 , further comprising anchoring a tissue anchor to the tissue site, and wherein attaching the first end portion of the artificial chord to the tissue site comprises coupling the first end portion of the artificial chord to the tissue the tissue anchor.

16 . The method according to claim 13 , wherein:

a tissue anchor comprises the first radiopaque marker, and

placing the first radiopaque marker against a tissue site in the ventricle comprises anchoring the tissue anchor to the tissue site.

17 . The method according to claim 13 , further comprising, subsequently to attaching at least one end portion from the group comprising: the first end portion and the second end portion, withdrawing from the heart at least one marker selected from the group consisting of:

the first radiopaque marker, and

the second radiopaque marker.

18 . The method according to claim 17 , wherein attaching the first end portion comprises attaching the first end portion of the chord to the tissue site:

subsequently to withdrawing the first radiopaque marker from the heart, and

prior to withdrawing the second radiopaque marker from the heart.

19 . The method according to claim 17 , wherein the step of withdrawing comprises, subsequently to attaching the first end portion and the second end portion, withdrawing from the heart at least one marker selected from the group consisting of:

the first radiopaque marker, and

the second radiopaque marker.

20 . The method according to claim 17 , wherein the step of withdrawing comprises, subsequently to attaching at least one end portion from the group comprising: the first end portion and the second end portion, withdrawing from the heart:

the first radiopaque marker, and

the second radiopaque marker.

21 . The method according to claim 17 , wherein the step of withdrawing comprises, subsequently to attaching the first end portion and the second end portion, withdrawing from the heart:

the first radiopaque marker, and

the second radiopaque marker.

22 . A method, comprising:

advancing a first radiopaque marker and a second radiopaque marker through vasculature to a heart, the heart having a native valve disposed between an atrium and a ventricle;

placing the first radiopaque marker against a tissue site in the ventricle;

attaching a first end portion of an artificial chord to the tissue site;

placing the second radiopaque marker against a component of the native valve;

fluoroscopically measuring a distance between the first radiopaque marker at the tissue site, and the second radiopaque marker at the component;

determining a chord-length responsively to the measured distance; and

responsively to the chord-length, attaching a second end portion of the artificial chord to the component of the native valve.

23 . The method according to claim 22 , wherein attaching the first end portion to the tissue site comprises attaching the first end portion to the tissue site responsively to the chord-length.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 23, 2025
From: REICH, TAL
To: VALTECH CARDIO, LTD.
Reel/Frame 071484/0616 →
CHANGE OF NAME Recorded Jun 23, 2025
From: VALTECH CARDIO LTD.
To: EDWARDS LIFESCIENCES INNOVATION (ISRAEL) LTD.
Reel/Frame 071695/0952 →
Continuity (4)
Continuation 16926580 · Jul 10, 2020
Continuation PCTIL2019050083 · Jan 22, 2019
Provisional Application 62622315 · Jan 26, 2018
Related Publication 20230248520A1 · Aug 10, 2023
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