Disinfectant composition with rapid antiviral efficacy
A disinfectant composition that contains a unique combination of a primary antiviral agent and a secondary antiviral agent is provided. More particularly, the primary antiviral agent includes a polyprotic acid having a low first acid dissociation constant and the secondary antiviral agent is selected from the group consisting of an anionic N-acyl compound, metal halide salt, amine compound, amine compound, aliphatic amine oxide, alkyl glycoside, alcohol ethoxylate, and combinations thereof. By selectively controlling the particular nature of each antiviral agent and their relative concentration, the present inventors have discovered that a synergistic affect can be achieved in which the disinfectant composition is capable of exhibiting an antiviral efficacy against non-enveloped viruses.
1 . A disinfectant composition comprising:
from about 0.1 wt. % to about 10 wt. % of a primary antiviral agent, wherein the primary antiviral agent includes a polyprotic acid having a first acid dissociation constant of about 3.0 or less;
from about 0.1 wt. % to about 15 wt. % of a secondary antiviral agent; and
from about 70 wt. % to about 99.5 wt. % of a solvent system that includes one or more solvents, wherein water constitutes at least 50 wt. % of the solvent system;
wherein the disinfectant composition has a pH of about 4.5 or less;
wherein the polyprotic acid is sulfosuccinic acid and the secondary antiviral agent is a metal halide salt.
2 . The disinfectant composition of claim 1 , wherein the metal halide salt is copper (II) chloride, iron (II) chloride, iron (III) chloride, zinc chloride, aluminum (III) chlonde, or aluminum chlorohydrate.
3 . The disinfectant composition of claim 1 , further comprising a cationic surfactant.
4 . The disinfectant composition of claim 1 , wherein the disinfectant composition exhibits a reduction in virus infectivity of about 30% or more after being exposed to a nonenveloped virus for 10 minutes.
5 . The disinfectant composition of claim 4 , wherein the disinfectant composition exhibits a reduction in virus infectivity of about 30% or more after being exposed to Phi X174 (ATCC 13706-B1) for 10 minutes.
6 . The disinfectant composition of claim 1 , wherein the disinfectant composition exhibits a reduction in virus infectivity of about 70% or more after being exposed to Phi X174 (ATCC 13706-B1) for 10 minutes.
7 . A method for disinfecting a surface, the method comprising contacting the surface with the disinfectant composition of claim 1 .
8 . The method of claim 7 , wherein the disinfectant composition is exposed to Phi X174 (ATCC 13706-B1) for 10 minutes, wherein the disinfectant composition exhibits a reduction in virus infectivity of about 30% or more, or 70% or more, after being exposed to Phi X174 (ATCC 13706-B1) for 10 minutes.
9 . The method of claim 7 , wherein the disinfectant composition is used against a non-enveloped virus selected from the families Picornaviridae, Reoviridae, Caliciviridae, Papovaviridae, Adenoviridae, Parvoviridae, and combinations thereof.
10 . The method of claim 7 , wherein the surface is a hard surface.
11 . The method of claim 7 , wherein the disinfectant composition is disposed on a wipe prior to being applied to the surface.
12 . A disinfectant composition comprising:
from about 0.1 wt. % to about 10 wt. % of a primary antiviral agent, wherein the primary antiviral agent includes a polyprotic acid having a first acid dissociation constant of about 3.0 or less;
from about 0.1 wt. % to about 15 wt. % of a secondary antiviral agent; and
from about 70 wt. % to about 99.5 wt. % of a solvent system that includes one or more solvents, wherein water constitutes at least 50 wt. % of the solvent system;
wherein the disinfectant composition has a pH of about 4.5 or less;
wherein the polyprotic acid is sulfosuccinic acid and the secondary antiviral agent is a metal halide salt, wherein the metal halide salt is copper (II) chloride.