IP Library Granted Patent US 12,580,071
Granted Patent B2
US 12,580,071 · App. 18/316,711 · Granted Mar 17, 2026

Systems and methods to process electronic images with automatic protocol revisions

Inventors: Jeremy Daniel Kunz (New York, NY); Donghun Lee (New York, NY)
Assignee: Paige.AI, Inc.
G16H30/40G06V10/70G16H15/00G16H30/20
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Quick Facts
Patent No.
US 12,580,071
App. No.
18/316,711
Granted
Mar 17, 2026
Kind
B2
Abstract

Systems and methods are described herein for processing electronic medical images. The method may include determining, using an automated routine, whether a pathology protocol is accessible; determining a first set of one or more training images, the first set of one or more training images comprising digital medical images annotated utilizing the pathology protocol; and providing the training images to a machine learning model capable of analyzing digital medical images according to the pathology protocol or guideline. The providing may further include determining a starting model, splitting the first set of one or more training images into a training set A and an evaluation set B of digital medical images, fine tuning the starting model with the training set A to determine the machine learning model, evaluating the machine learning model with the training set B, and upon receiving a passing evaluation, saving the determined machine learning model.

Claims (54)

1 . A computer-implemented method for processing electronic medical images comprising:

determining, using an automated routine, whether a pathology protocol is accessible;

determining a first set of one or more training images, the first set of one or more training images comprising digital medical images annotated utilizing the pathology protocol; and

providing the training images to a machine learning model capable of analyzing digital medical images according to the pathology protocol or guideline, the providing further including:

determining a starting model;

splitting the first set of one or more training images into a training set A and an evaluation set B of digital medical images;

fine tuning the starting model with the training set A to determine the machine learning model;

evaluating the machine learning model with the training set B; and

upon receiving a passing evaluation, saving the determined machine learning model to digital storage.

2 . The method of claim 1 , wherein upon determining that a pathology protocol is accessible further comprises:

parsing data of the pathology protocol;

determining a new synoptic report based on the parsed data; and

providing the new synoptic report to the machine learning model.

3 . The method of claim 1 , wherein the training images include annotations of digital medical images, the annotations being performed according to the pathology protocol, wherein the annotations comprise measurements, designations, and/or diagnosis.

4 . The method of claim 1 , wherein determining whether a pathology protocol is available is performed iteratively at predetermined time intervals.

5 . The method of claim 1 , wherein the pathology protocol is a new cancer protocol template.

6 . The method of claim 1 , wherein the pathology protocol is a PDF, word document, or CSV document.

7 . The method of claim 1 , wherein the starting model in a machine learning model trained on a previous version of the pathology protocol.

8 . The method of claim 1 , further including:

determining a new synoptic report based on the pathology guideline, the machine learning model being trained to fill out the new synoptic report when analyzing new digital medical images.

9 . The method of claim 8 , wherein determining a new synoptic report includes automatically creating, by a machine learning system and/or a rules-based artificial intelligence algorithm, a new synoptic report.

10 . The method of claim 8 , wherein determining a new synoptic reports includes receiving a synoptic report corresponding to the pathology protocol or guideline from an external user or system.

11 . The method of claim 1 , wherein the machine learning model is not determined until the determined first set of one or more training images exceed a threshold value of training images.

12 . The method of claim 1 , further including:

determining the machine learning model has been applied to a predetermined number of slides to meet a study requirement.

13 . A system for processing electronic medical images, the system comprising:

at least one memory storing instructions; and

at least one processor configured to execute the instructions to perform operations comprising:

determining, using an automated routine, whether a pathology protocol is accessible;

determining a first set of one or more training images, the first set of one or more training images comprising digital medical images annotated utilizing the pathology protocol; and

providing the training images to a machine learning model capable of analyzing digital medical images according to the pathology protocol or guideline, the providing further including:

determining a starting model;

splitting the first set of one or more training images into a training set A and an evaluation set B of digital medical images;

fine tuning the starting model with the training set A to determine the machine learning model;

evaluating the machine learning model with the training set B; and

upon receiving a passing evaluation, saving the determined machine learning model to digital storage.

14 . The system of claim 13 , wherein upon determining that a pathology protocol is available further comprises:

parsing data of the pathology protocol;

determining a new synoptic report based on the parsed data; and

providing the new synoptic report to the machine learning model.

15 . The system of claim 13 , wherein the training images include annotations of digital medical images, the annotations being performed according to the pathology protocol, wherein the annotations comprise measurements, designations, and/or diagnosis.

16 . The system of claim 13 , wherein determining whether a pathology protocol is available is performed iteratively at predetermined time intervals.

17 . The system of claim 13 , wherein the pathology protocol is a new cancer protocol template.

18 . The system of claim 13 , wherein the pathology protocol is a PDF, word document, or CSV document.

19 . The system of claim 13 , wherein the starting model in a machine learning model trained on a previous version of the pathology protocol.

20 . A non-transitory computer-readable medium storing instructions that, when executed by a processor, perform operations processing electronic medical images, the operations comprising:

determining, using an automated routine, whether a pathology protocol is accessible;

determining a first set of one or more training images, the first set of one or more training images comprising digital medical images annotated utilizing the pathology protocol; and

providing the training images to a machine learning model capable of analyzing digital medical images according to the pathology protocol or guideline, the providing further including:

determining a starting model;

splitting the first set of one or more training images into a training set A and an evaluation set B of digital medical images;

fine tuning the starting model with the training set A to determine the machine learning model;

evaluating the machine learning model with the training set B; and

upon receiving a passing evaluation, saving the determined machine learning model to digital storage.

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded May 14, 2026
From: ARES CAPITAL CORPORATION, AS COLLATERAL AGENT
To: PAIGE.AI, INC.
Reel/Frame 075589/0752 →
SECURITY INTEREST Recorded Oct 21, 2025
From: PAIGE.AI, INC.
To: ARES CAPITAL CORPORATION, AS COLLATERAL AGENT
Reel/Frame 073216/0876 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 27, 2023
From: KUNZ, JEREMY DANIEL; LEE, DONGHUN
To: PAIGE.AI, INC.
Reel/Frame 064411/0076 →
Continuity (2)
Provisional Application 63341504 · May 13, 2022
Related Publication 20230368899A1 · Nov 16, 2023
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