Granted Patent
B2
US 12,435,132 · App. 18/322,737 · Granted Oct 7, 2025
Anti-IL31 antibodies for veterinary use
Inventors:
Shyr Jiann Li (Millbrae, CA); Lam Nguyen (Union City, CA); Hangjun Zhan (Foster City, CA)
Assignee:
Elanco US Inc.
C07K16/244A61K2039/552C07K2317/24C07K2317/33C07K2317/34C07K2317/52C07K2317/56C07K2317/565C07K2317/76C07K2317/92C07K2317/94
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Abstract
Provided are various embodiments relating to anti-IL31 antibodies binding to canine IL31. Such antibodies can be used in methods to treat IL31-induced conditions in companion animals, such as canines, felines, and equines.
Claims (29)
1. A method of reducing IL31 signaling in a canine cell or a feline cell, the method comprising exposing to the canine cell or the feline cell an antibody comprising:
a) (i) a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 1,
(ii) a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 2,
(iii) a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 3, and
b) (i) a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 8,
(ii) a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 9,
(iii) a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 10.
2. The method of claim 1 , wherein the antibody comprises:
a) (i) a variable light chain sequence having at least 95% sequence identity to the amino acid sequence of SEQ ID NO: 24; (ii) a variable heavy chain sequence having at least 95% sequence identity to the amino acid sequence of SEQ ID NO: 25; or (iii) a variable light chain sequence as in (i) and a variable heavy chain sequence as in (ii); or
b) (i) a variable light chain sequence having at least 95% sequence identity to the amino acid sequence of SEQ ID NO: 16; (ii) a variable heavy chain sequence having at least 95% sequence identity to the amino acid sequence of SEQ ID NO: 15; or (iii) a variable light chain sequence as in (i) and a variable heavy chain sequence as in (ii).
3. The method of claim 1 , wherein the antibody comprises (a) a canine heavy chain constant region selected from an IgG-A, IgG-B, IgG-C, and IgG-D constant region; or (b) a feline heavy chain constant region selected from an IgG1, IgG2a, and IgG2b constant region.
4. The method of claim 1 , wherein the antibody comprises:
a) (i) a light chain amino acid sequence of SEQ ID NO: 26; (ii) a heavy chain amino acid sequence of SEQ ID NO: 27; or (iii) a light chain amino acid sequence as in (i) and a heavy chain amino acid sequence as in (ii); or
b) (i) a light chain amino acid sequence of SEQ ID NO: 30; (ii) a heavy chain amino acid sequence of SEQ ID NO: 31; or (iii) a light chain amino acid sequence as in (i) and a heavy chain amino acid sequence as in (ii).
5. The method of claim 1 , wherein the antibody binds to canine IL31 with a dissociation constant (Kd) of between 5×10 −11 M and 1×10 −12 M, as measured by biolayer interferometry.
6. The method of claim 1 , wherein the antibody is a monoclonal antibody.
7. The method of claim 1 , wherein the antibody is a caninized or a felinized antibody.
8. The method of claim 1 , wherein the antibody is an antibody fragment selected from Fv, scFv, Fab, Fab′, F(ab′) 2 , and Fab′-SH.
9. The method of claim 1 , wherein the method comprises administering in combination with the antibody:
a) a Jak inhibitor, a PI3K inhibitor, an AKT inhibitor, or a MAPK inhibitor; or
b) one or more antibodies selected from an anti-IL17 antibody, an anti-TNFα antibody, an anti-CD20 antibody, an anti-CD19 antibody, an anti-CD25 antibody, an anti-IL4 antibody, an anti-IL13 antibody, an anti-IL23 antibody, an anti-IgE antibody, an anti-CD11a antibody, anti-IL6R antibody, anti-α4-Intergrin antibody, an anti-IL 12 antibody, an anti-IL1β antibody, and an anti-BlyS antibody.
10. The method of claim 1 , wherein the cell is exposed to the antibody ex vivo.
11. The method of claim 1 , wherein the antibody further comprises one or more of (a) a variable region heavy chain framework 1 (HC-FR1) sequence of SEQ ID NO: 4; (b) a HC-FR2 sequence of SEQ ID NO: 5; (c) a HC-FR3 sequence of SEQ ID NO: 6; (d) a HC-FR4 sequence of SEQ ID NO: 7; (e) a variable region light chain framework 1 (LC-FR1) sequence of SEQ ID NO: 11; (f) an LC-FR2 sequence of SEQ ID NO: 12; (g) an LC-FR3 sequence of SEQ ID NO: 13; or (h) an LC-FR4 sequence of SEQ ID NO: 14.
12. The method of claim 1 , wherein the antibody comprises a variable light chain sequence having at least 95% sequence identity to the amino acid sequence of SEQ ID NO: 16 and a variable heavy chain sequence having at least 95% sequence identity to the amino acid sequence of SEQ ID NO: 15.
13. The method of claim 12 , wherein the antibody comprises a variable light chain sequence comprising SEQ ID NO: 16 and a variable heavy chain sequence comprising SEQ ID NO: 15.
14. The method of claim 12 , wherein the antibody comprises a canine heavy chain constant region from an IgG-B constant region.
15. The method of claim 13 , wherein the antibody comprises a canine heavy chain constant region from an IgG-B constant region.
16. The method of claim 1 , wherein the antibody comprises the light chain amino acid sequence of SEQ ID NO: 21.
17. The method of claim 1 , wherein the antibody comprises a heavy chain amino acid sequence of SEQ ID NO: 17; SEQ ID NO: 18; SEQ ID NO: 19; or SEQ ID NO: 20.
Assignments (2)
MERGER AND CHANGE OF NAME
Recorded Oct 2, 2023
From: KINDRED BIOSCIENCES, INC.; ELANCO US INC.
To: ELANCO US INC.
Reel/Frame 065091/0055 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 24, 2023
From: LI, SHYR JIANN; NGUYEN, LAM; ZHAN, HANGJUN
To: KINDRED BIOSCIENCES, INC.
Reel/Frame 063745/0375 →
Continuity (6)
Provisional Application
62463543
· Feb 24, 2017
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