MEK inhibitors and uses thereof
The present disclosure provides MEK inhibitors, compositions thereof, and methods of using the same.
1. A compound selected from:
I-1
I-2
I-37
I-40
I-41
I-42
I-43
I-45
I-46
I-54
I-55
I-64
I-112
I-133
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , which is:
or a pharmaceutically acceptable salt thereof.
3. The compound of claim 1 , which is:
or a pharmaceutically acceptable salt thereof.
4. The compound of claim 1 , which is:
or a pharmaceutically acceptable salt thereof.
5. The compound of claim 1 , which is:
or a pharmaceutically acceptable salt thereof.
6. The compound of claim 1 , which is:
or a pharmaceutically acceptable salt thereof.
7. The compound of claim 1 , which is:
or a pharmaceutically acceptable salt thereof.
8. The compound of claim 1 , which is:
or a pharmaceutically acceptable salt thereof.
9. The compound of claim 1 , which is:
or a pharmaceutically acceptable salt thereof.
10. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
11. A pharmaceutical composition comprising a compound selected from:
I-1
I-2
I-37
I-40
I-41
I-42
I-43
I-45
I-46
I-54
I-55
I-64
I-112
I-133
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant, or vehicle.
12. The pharmaceutical composition of claim 11 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
13. The pharmaceutical composition of claim 11 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
14. The pharmaceutical composition of claim 11 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
15. The pharmaceutical composition of claim 11 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
16. The pharmaceutical composition of claim 11 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
17. The pharmaceutical composition of claim 11 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
18. The pharmaceutical composition of claim 11 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
19. The pharmaceutical composition of claim 11 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
20. The pharmaceutical composition of claim 11 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
21. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
22. The pharmaceutical composition of claim 11 , wherein the compound is
or a pharmaceutically acceptable salt thereof.