IP Library Granted Patent US 12,675,861
Granted Patent B2
US 12,675,861 · App. 18/330,745 · Granted Jul 7, 2026

Systems and methods for processing electronic images to identify transplant donor-recipient matches

Inventors: Jeremy Daniel Kunz (New York, NY); Christopher Kanan (Pittsford, NY)
Assignee: Paige.AI, Inc.
G06T7/0002G16H10/60G16H50/20G16H50/70A61B2017/00969G06T2207/20081G06T2207/30056
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Quick Facts
Patent No.
US 12,675,861
App. No.
18/330,745
Filed
Jun 7, 2023
Granted
Jul 7, 2026
Kind
B2
Art Unit
2668
USPC
382/128
Abstract

Systems and methods are described herein for processing electronic medical images to predict one or more donor recipients for a patient. For example, a digital medical image of the patient may be received, wherein the patient is in need of a transplant. A trained machine learning system may be determined. The digital medical image may be provided into the trained machine learning system, the trained machine learning system determining a patient embedding. Using the patient embedding, a subset of donor recipients may be determined. Based on the subset of donor recipients a recommendation of optimal donors may be determined.

Claims (46)

1 . A computer-implemented method for processing electronic medical images to predict one or more donors for a subject, comprising:

receiving a digital medical image of the subject, wherein the subject is in need of a transplant;

determining a trained machine learning system;

providing the digital medical image into the trained machine learning system, the trained machine learning system determining a subject embedding;

determining, using the subject embedding, a subset of donors;

determining based on the subset of donors a recommendation of optimal donors; and

determining a second trained machine learning system, the second trained machine learning system being capable of determining a dietary, sleep, or exercise suggestion, wherein the second trained machine learning system receives as input the digital medical image of the subject, determines a lifestyle embedding, and determines, based on the lifestyle embedding, a dietary, sleep, or exercise suggestion for the subject.

2 . The method of claim 1 , wherein the transplant is a fecal matter transplant.

3 . The method of claim 1 , wherein the transplant is a liver transplant.

4 . The method of claim 1 , wherein a salient region detection module is applied to determine a saliency of each region within the received digital medical image, and non-salient image regions are excluded from processing by the trained machine learning system.

5 . The method of claim 1 further including:

receiving metadata corresponding to the subject, the metadata comprising: clinical data, genetic information, microbial composition, and/or life history data; and

providing the metadata into the trained machine learning system.

6 . The method of claim 1 , further including:

notifying, with a notification, donor collection entities of a need for donors with a given profile.

7 . The method of claim 6 , wherein the notification may include metadata of the subject in need, an indication of the donor profile needed that matches the recipient, and/or a request for the donor collection entities to start collecting donors that have a similar profile.

8 . A system for processing electronic medical images to predict one or more donors for a subject, the system comprising:

at least one memory storing instructions; and

at least one processor configured to execute the instructions to perform operations comprising:

receiving a digital medical image of the subject, wherein the subject is in need of a transplant;

determining a trained machine learning system;

providing the digital medical image into the trained machine learning system, the trained machine learning system determining a subject embedding;

determining, using the subject embedding, a subset of donors;

determining based on the subset of donors a recommendation of optimal donors; and

determining a second trained machine learning system, the second trained machine learning system being capable of determining a dietary, sleep, or exercise suggestion, wherein the second trained machine learning system receives as input the digital medical image of the subject, determines a lifestyle embedding, and determines, based on the lifestyle embedding, a dietary, sleep, or exercise suggestion for the subject.

9 . The system of claim 8 , wherein the transplant is a fecal matter transplant.

10 . The system of claim 8 , wherein the transplant is a liver transplant.

11 . The system of claim 8 , wherein a salient region detection module is applied to determine a saliency of each region within the received digital medical image, and non-salient image regions are excluded from processing by the trained machine learning system.

12 . The system of claim 8 further including:

receiving metadata corresponding to the subject, the metadata comprising: clinical data, genetic information, microbial composition, and/or life history data; and

providing the metadata into the trained machine learning system.

13 . The system of claim 8 further including:

notifying, with a notification, donor collection entities of a need for donors with a given profile.

14 . The system of claim 13 , wherein the notification may include metadata of the subject in need, an indication of the donor profile needed that matches the recipient, and/or a request for the donor collection entities to start collecting donors that have a similar profile.

15 . A non-transitory computer-readable medium storing instructions that, when executed by a processor, perform operations processing electronic medical images to predict one or more donors for a subject, the operations comprising:

receiving a digital medical image of the subject, wherein the subject is in need of a transplant;

determining a trained machine learning system;

providing the digital medical image into the trained machine learning system, the trained machine learning system determining a subject embedding;

determining, using the subject embedding, a subset of donors recipients; and

determining based on the subset of donors a recommendation of optimal donors; and

determining a second trained machine learning system, the second trained machine learning system being capable of determining a dietary, sleep, or exercise suggestion, wherein the second trained machine learning system receives as input the digital medical image of the subject, determines a lifestyle embedding, and determines, based on the lifestyle embedding, a dietary, sleep, or exercise suggestion for the subject.

16 . The non-transitory computer-readable medium of claim 15 , further including:

receiving metadata corresponding to the subject, the metadata comprising: clinical data, genetic information, microbial composition, and/or life history data; and

providing the metadata into the trained machine learning system.

17 . The non-transitory computer-readable medium of claim 15 , further including:

notifying, with a notification, donor collection entities of a need for donors with a given profile, wherein the notification may include metadata of the subject in need, an indication of the donor profile needed that matches the recipient, and/or a request for the donor collection entities to start collecting donors that have a similar profile.

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded May 14, 2026
From: ARES CAPITAL CORPORATION, AS COLLATERAL AGENT
To: PAIGE.AI, INC.
Reel/Frame 075589/0752 →
SECURITY INTEREST Recorded Oct 21, 2025
From: PAIGE.AI, INC.
To: ARES CAPITAL CORPORATION, AS COLLATERAL AGENT
Reel/Frame 073216/0876 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 15, 2023
From: KUNZ, JEREMY DANIEL; KANAN, CHRISTOPHER
To: PAIGE.AI, INC.
Reel/Frame 063965/0124 →
Continuity (2)
Provisional Application 63366015 · Jun 8, 2022
Related Publication 20230401685A1 · Dec 14, 2023
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