IP Library Granted Patent US 12,310,594
Granted Patent B2
US 12,310,594 · App. 18/331,555 · Granted May 27, 2025

Collateral flow channel sealant delivery methods and systems

Inventors: Sri Radhakrishnan (Cupertino, CA); Ryan Olivera (Granite Bay, CA)
Assignee: Pulmonx Corporation
A61B17/12104A61B5/08A61B5/4848A61B17/1204A61B17/12136A61M16/0406A61M16/042A61M16/0459A61M25/0147A61M25/10A61F2002/043A61F2250/0067A61M2025/0001A61M2202/0413A61M2202/0468A61M2205/502
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Quick Facts
Patent No.
US 12,310,594
App. No.
18/331,555
Granted
May 27, 2025
Kind
B2
Abstract

Devices, methods, and systems are provided for occluding a collateral flow channel between a target lung compartment and an adjacent lung compartment. A video-assisted thoracoscopic device is inserted into a thoracic cavity of a patient and positioned at a fissure between a target lung compartment and an adjacent lung compartment. A collateral flow channel between the target lung compartment and the adjacent lung compartment is then identified using the video-assisted thoracoscopic device and an agent is injected into the collateral flow channel, thereby reducing the collateral flow channel.

Claims (16)

1. A system for occluding a collateral flow channel and treating emphysema, the system comprising:

a video-assisted thoracoscopic surgical device that is configured to be inserted into a thoracic cavity of a patient to identify a collateral flow channel between a target lung compartment and an adjacent lung compartment;

a closure device that is configured to be inserted into the thoracic cavity of the patient to close the collateral flow channel between the target lung compartment and the adjacent lung compartment and thereby disrupt the collateral flow channel, wherein the thoracic closure device comprises a stapling device; and

an endobronchial valve that is implantable in an airway leading to the target lung compartment to treat emphysema.

2. The system of claim 1 , wherein the closure device is configured to seal the collateral flow channel.

3. The system of claim 1 , wherein the endobronchial valve comprises a one-way flow control valve configured to allow air flow out of the target lung compartment and prevent air flow into the target lung compartment.

4. The system of claim 1 , wherein the video-assisted thoracoscopic surgical device comprises a thoracoscope having a light source and a video camera configured to transmit video to an external monitor.

5. The system of claim 1 , further comprising an endobronchial catheter having an occlusion element.

6. The system of claim 5 , wherein the occlusion element comprises an expandable balloon configured to isolate the target lung compartment, wherein flow within the target lung compartment is measured to determine the presence or absence of collateral flow.

7. A system for occluding a collateral flow channel and treating emphysema, the system comprising:

a stapling device that is configured to be inserted into a thoracic cavity of a patient via a video-assisted thoracoscopic surgical device to close a collateral flow channel between a target lung compartment and an adjacent lung compartment from the thoracic cavity and thereby disrupt the collateral flow channel; and

an endobronchial valve that is implantable in an airway leading to the target lung compartment to treat emphysema.

8. The system of claim 7 , wherein the endobronchial valve comprises a one-way flow control valve configured to allow air flow out of the target lung compartment and prevent air flow into the target lung compartment.

9. The system of claim 7 , further comprising an endobronchial catheter having an occlusion element.

10. The system of claim 9 , wherein the occlusion element comprises an expandable balloon configured to isolate the target lung compartment, wherein flow within the target lung compartment is measured to determine the presence or absence of collateral flow.

11. The system of claim 10 , wherein the stapling device is configured to seal the collateral flow channel.

Assignments (3)
SECURITY INTEREST Recorded Mar 2, 2026
From: PULMONX CORPORATION
To: PERCEPTIVE CREDIT HOLDINGS V, LP, AS ADMINISTRATIVE AGENT
Reel/Frame 075012/0453 →
SECURITY INTEREST Recorded Jan 27, 2026
From: PULMONX CORPORATION
To: CANADIAN IMPERIAL BANK OF COMMERCE
Reel/Frame 074570/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 15, 2023
From: RADHAKRISHNAN, SRI; OLIVERA, RYAN
To: PULMONX CORPORATION
Reel/Frame 063966/0836 →
Continuity (4)
Continuation 16532820 · Aug 6, 2019
Continuation 15182453 · Jun 14, 2016
Provisional Application 62183170 · Jun 22, 2015
Related Publication 20240008874A1 · Jan 11, 2024
References Cited (22)
US 4351344A · Stenzler · 1982 [cited by applicant]
US 7798147B2 · Hendricksen et al. · 2010 [cited by applicant]
US 7819908B2 · Ingenito · 2010 [cited by applicant]
US 7883471B2 · Aljuri et al. · 2011 [cited by applicant]
US 8136526B2 · Perkins et al. · 2012 [cited by applicant]
US 8137302B2 · Aljuri et al. · 2012 [cited by applicant]
US 8445589B2 · Ingenito et al. · 2013 [cited by applicant]
US 9364168B2 · Mantri · 2016 [cited by applicant]
US 10413300B2 · Radhakrishnan et al. · 2019 [cited by applicant]
US 11696763B2 · Radhakrishnan et al. · 2023 [cited by applicant]
US 20030051733A1 · Kotmel et al. · 2003 [cited by applicant]
US 20030228344A1 · Fields · 2003 [cited by examiner]
US 20040200484A1 · Springmeyer · 2004 [cited by applicant]
US 20070043350A1 · Soltesz · 2007 [cited by examiner]
US 20070142742A1 · Aljuri et al. · 2007 [cited by applicant]
US 20080027343A1 · Fields et al. · 2008 [cited by applicant]
US 20110201956A1 · Alferness et al. · 2011 [cited by applicant]
US 20120149978A1 · Olivera · 2012 [cited by examiner]
US 20120149995A1 · Mantri et al. · 2012 [cited by applicant]
US 20120150057A1 · Mantri · 2012 [cited by applicant]
WO 2009135070A1 · 2009 [cited by applicant]
Dernevik , et al. , “Initial Experience with the World's First Digital Drainage System. The Benefits of Recording Air Leaks with Graphic Representation” , European Journal of Cardio-Thoracic Surgery, vol. 31, No. 2 , Fe… [cited by applicant]