Lumen coating method and apparatus
A method for coating the lumen of a tube comprises the steps of inserting the distal opening of a tube into a first coating solution, drawing the first coating solution into the lumen of the tube, draining the first coating solution from the lumen leaving a film of the first coating solution on the lumen of the tube, and curing the first coating solution. This leaves a first coating on the lumen of the tube. A coating apparatus comprises a pallet, and one or more dip funnels. The pallet comprises a manifold and is configured to fluidically connect the manifold to one or more tubes. The one or more dip funnels are configured to hold a coating solution and are located below the pallet so that when the pallet is moved vertically, the one or more tubes are inserted into the dip funnels.
1. A method for coating the lumen of a tube comprising the steps of:
inserting the distal opening of the tube into a first coating solution,
drawing the first coating solution into the lumen of the tube,
draining the first coating solution from the lumen leaving a film of the first coating solution on the lumen of the tube,
curing the first coating solution, wherein the first coating solution comprises a mixture of polyaziridine and either polyurethane or polyacrylate,
inserting the distal opening of the tube into a second coating solution,
drawing the second coating solution into the lumen of the tube,
draining the second coating solution from the lumen leaving a film of the second coating solution on the lumen of the tube, and
curing the second coating solution, wherein the second coating solution comprises polysaccharide and/or polyacrylic acid.
2. The method of claim 1 , further comprising the steps of:
inserting at least a portion of the tube into the first coating solution before or simultaneous with the step of drawing the first coating solution into the lumen of the tube, and
before, during, or after draining the first coating solution from the lumen, removing a least a portion of the tube from the first coating solution leaving a film of the first coating solution on the outside surface of the tube.
3. The method of claim 1 , further comprising the steps of:
inserting at least a portion of the tube into the second coating solution before or simultaneous with the step of drawing the second coating solution into the lumen of the tube, and
before, during, or after draining the second coating solution from the lumen, removing a least a portion of the tube from the second coating solution leaving a film of the second coating solution on the outside surface of the tube.
4. The method of claim 1 , further comprising the steps of:
inserting at least a portion of the tube into the second coating solution before or simultaneous with the step of drawing the second coating solution into the lumen of the tube, and
before, during, or after draining the second coating solution from the lumen, removing a least a portion of the tube from the second coating solution leaving a film of the second coating solution on the outside surface of the tube.
5. The method of claim 1 , wherein the first coating solution is drained from the lumen by flowing a gas through the lumen.
6. The method of claim 1 , further comprising the step of flowing a cleaning solution through the tube.
7. The method of claim 1 , wherein the first coating solution further comprising a short chain alcohol.
8. The method of claim 7 , wherein the first coating solution additionally comprises a zirconate or titanate compound.
9. The method of claim 1 , wherein the second coating solution additionally comprises a crosslinker.
10. The method of claim 1 , wherein the tube is a catheter.
11. The method of claim 1 , wherein the polyaziridine comprises a cross liker selected from trimethylolpropane tris(2-methyl-1-aziridine propionate) (TMAZ), N,N′-(methylenedi-p-phenylene)bis(aziridine-1-carboxamide)(DAZ), trimethylolpropane bis(2-methyl-1-aziridine propionate), pentaerythritol bis(3-(1-aziridinyl) propionate, pentaerythritol tris(3-(1-aziridinyl) propionate (TAZ), and pentaerythritol tetrakis(3-(1-aziridinyl) propionate.
12. The method of claim 1 , wherein the polyaziridine comprises a cross liker selected from trimethylolpropane tris(2-methyl-1-aziridine propionate) (TMAZ), N,N′-(methylenedi-p-phenylene)bis (aziridine-1-carboxamide)(DAZ), and pentaerythritol tris(3-(1-aziridinyl) propionate (TAZ).
13. The method of claim 1 , wherein the polyaziridine comprises trimethylolpropane tris(2-methyl-1-aziridine propionate) (TMAZ).