DELIVERY DEVICES FOR DELIVERING AND METHODS OF DELIVERING COMPOSITIONS
Disclosed embodiments relate to devices and related methods for delivering a composition to a subject. In some embodiments, a device may include a catheter coupled to a handle. The handle may include proximal and distal handle portions that are moveable relative to one another to selectively expose a needle at a distal end of the catheter. The proximal handle portion may include a container coupling and a grip extending proximally from the container coupling.
1 . A device for delivering a composition to a subject, comprising:
a catheter comprising:
an outer sheath tube,
an inner tube, and
a hollow needle coupled to a distal end of the inner tube; and
a handle comprising:
a proximal handle portion including a container coupling and a grip extending proximally relative to the container coupling,
a distal handle portion coupled to the outer sheath tube, and
a channel extending through the handle and fluidly coupled with the container coupling, wherein the inner tube extends at least partially along a length of the channel and is in fluid communication with the container coupling,
wherein the proximal and distal handle portions are moveable relative to one another between a first position in which the needle is retracted within the outer sheath tube and a second position in which the needle extends from the outer sheath tube.
2 . The device of claim 1 , wherein the container coupling is configured to couple to a syringe.
3 . The device of claim 2 , wherein the syringe extends substantially parallel to the grip when coupled to the container coupling.
4 . The device of claim 2 , wherein the container coupling comprises a luer fitting.
5 . The device of claim 1 , further comprising a finger loop positioned adjacent a proximal end of the grip.
6 . The device of claim 1 , further comprising one or more hypotubes disposed within the channel of the handle.
7 . The device of claim 6 , wherein the inner tube extends through the one or more hypotubes.
8 . The device of claim 6 , wherein a first hypotube of the one or more hypotubes is attached to the inner tube.
9 . The device of claim 8 , wherein a second hypotube of the one or more hypotubes is attached to the handle, and the first hypotube is moveable through the second hypotube.
10 . The device of claim 1 , wherein a length of the catheter is between about 300 mm and about 1000 mm.
11 . The device of claim 1 , further comprising an endoscope having a working channel, wherein at least a portion of the catheter is received within the working channel.
12 . The device of claim 1 , wherein the proximal and distal handle portions are axially slideable relative to one another to move between the first and second positions.
13 . The device of claim 12 , wherein the handle comprises a keyed arrangement constructed and arranged to prevent rotation of the proximal handle portion relative to the distal handle portion.
14 . The device of claim 13 , wherein the keyed arrangement comprises a rail formed on the proximal handle portion received in a groove formed in the distal handle portion.
15 . The device of claim 1 , wherein the channel is tapered such that an inner diameter of the channel decreases from a proximal to distal direction.
16 . (canceled)
17 . The device of claim 16 , wherein the first taper angle is greater than the second taper angle.
18 . The device of claim 1 , wherein the inner tube has a wall thickness of 50 μm to 600 μm.
19 . The device of claim 1 , wherein the inner tube includes a reinforcement feature comprising a microfilament attached to a wall of the inner tube.
20 . The device of claim 1 , further comprising a sleeve surrounding a portion of the outer sheath tube, the sleeve being freely slidable over the outer sheath tube.
21 . A method of administering a composition, comprising:
gripping a handle of a delivery device with a first hand, wherein the delivery device includes a catheter extending distally from the handle, and at least a portion of the catheter is received in a working channel of an endoscope;
gripping a handle of the endoscope with the first hand while gripping the handle of the delivery device; and
depressing a plunger of a syringe with a first finger of the first hand to deliver a compound through the catheter, wherein the syringe is coupled to the handle of the delivery device.
22 - 29 . (canceled)