Granted Patent
B2
US 12,359,162 · App. 18/352,788 · Granted Jul 15, 2025
Microbial cells, methods of producing the same, and uses thereof
Inventors:
James Scott Drouillard (Manhattan, KS); Celine Caroline Aperce (Wamego, KS); Gina Rae Herren (Wamego, KS); Tara Jo Ellerman (Manhattan, KS); Ciana Marie Scaletti (Manhattan, KS); Katherine Van Jordan (Manhattan, KS); James Morris Lattimer (Manhattan, KS); Scott Beyer (Manhattan, KS); Solange Uwituze (Kampala, UG); Teresa Lea Douthit (Manhattan, KS); Christina Denise Gunkel (Broken Bow, NE)
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Abstract
The present invention relates to microbial cells, including but not limited to aerobic bacteria cells and anaerobic bacteria cells, as well as yeast cells, and methods for producing the cells, feed additives and compositions comprising the cells, and uses involving administration of the cells to animals.
Claims (8)
1. A method for treating or preventing a condition or disorder associated with lactic acid production in the gastrointestinal tract of a non-ruminant animal, comprising administering to the non-ruminant animal about 0.4 g of freeze-dried Megasphaera elsdenii ( M. elsdenii ) NCIMB 41125 cells, wherein the 0.4 g of freeze-dried M. elsdenii NCIMB 41125 cells contain about 7.02×10 8 CFU/mL of M. elsdenii NCIMB 41125 cells.
2. The method of claim 1 , wherein the condition or disorder is acidosis.
3. The method of claim 1 , wherein the non-ruminant animal is selected from the group consisting of: swine, chicken, goose, duck, quail, turkey, pigeon, horse, pony, donkey, and mule.
4. The method of claim 1 , wherein the M. elsdenii NCIMB 41125 cells are administered in a feed mixture or a liquid.
5. The method of claim 1 , wherein the M. elsdenii NCIMB 41125 cells are administered prior to, concomitantly with, or after feeding the non-ruminant animal with a food.
6. The method of claim 1 , comprising a single administration of the M. elsdenii NCIMB 41125 cells, a daily administration of the M. elsdenii NCIMB 41125 cells or more than one administration of the M. elsdenii NCIMB 41125 cells on a single day.
7. The method of claim 1 , wherein the freeze dried M. elsdenii NCIMB 41125 cells are administered via a treat.
8. The method of claim 4 , wherein the liquid is administered by oral gavage or by spraying the non-ruminant animal with the liquid.
Assignments (4)
SECURITY INTEREST
Recorded Feb 13, 2026
From: AXIOTA U.S., INC. (F/K/A MS BIOTECH, INC.)
To: ALTER DOMUS (US), LLC, AS ADMINISTRATIVE AGENT
Reel/Frame 073782/0124 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 11, 2025
From: HERREN, GINA RAE
To: MS BIOTECH, INC.
Reel/Frame 071383/0727 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 11, 2025
From: DROUILLARD, JAMES SCOTT; APERCE, CELINE CAROLINE; ELLERMAN, TARA JO; SCALETTI, CIANA MARIE; VAN JORDAN, KATHERINE; LATTIMER, JAMES MORRIS; BEYER, SCOTT; UWITUZE, SOLANGE; DOUTHIT, TERESA LEA; GUNKEL, CHRISTINA DENISE
To: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
Reel/Frame 071541/0698 →
CHANGE OF NAME
Recorded Jun 11, 2025
From: MS BIOTECH, INC.
To: AXIOTA U.S., INC.
Reel/Frame 071541/0813 →
Continuity (6)
Continuation
16481962
Provisional Application
62510723
· May 24, 2017
Provisional Application
62452804
· Jan 31, 2017
Provisional Application
62452816
· Jan 31, 2017
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