IP Library Granted Patent US 7,550,139
Granted Patent B2
US 7,550,139 · App. 10/521,847 · Granted Jun 23, 2009

Patent

Assignees: Agricultural Research Council; Yara Phosphates Oy
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Quick Facts
Patent No.
US 7,550,139
App. No.
10/521,847
Granted
Jun 23, 2009
Kind
B2
Abstract

This invention relates to a novel strain of Megasphaera elsdenii and its uses. This invention further relates to preparations and methods incorporating such strain. This invention also relates to feedstuffs for ruminants and a preparation and method for the prevention and treatment of lactic acidosis in ruminants. This invention even further relates to a method of isolating a biologically pure culture of a superior ruminal microorganism in a relatively shorter time period than conventional methods. This invention yet further relates to a method of achieving any one or more of the following improvements in ruminants namely increased milk production; improved feedlot performance; improved growth rate; decrease in finishing time; lower digestive morbidity and mortality; lower incidence of lactic acidosis and related diseases; improved feed conversion efficiency; decrease in roughage content in feeds; and capability to feed on relatively higher concentrate diets.

Claims (15)

1. A biologically pure bacterial culture of M. elsdenii strain CH4 deposited at NCIMB, Aberdeen, Scotland, UK under number NCIMB 41125.

2. The biologically pure bacterial culture of claim 1 which is further characterised by its ability to utilize lactate at a rate of between 40% and 90% in the presence of sugars.

3. A composition for facilitating the adaptation of ruminants from a roughage-based diet to a high-energy concentrate-based diet, the composition comprising the bacterial culture of claim 1 .

4. A method for facilitating the adaptation of ruminants from a roughage-based diet to a high-energy concentrate-based diet, the method comprising administering to the rumen of said ruminants an effective amount of the composition of claim 3 .

5. A feed-additive for ruminants comprising a carrier and an effective amount of the bacterial culture of claim 1 .

6. A feed-additive according to claim 5 wherein the culture is disposed in an anaerobic container.

7. A method for the treatment of ruminal lactic acidosis comprising anaerobically administering to the rumen of a ruminant an effective amount of a bacterial culture according to claim 1 .

8. The method of claim 7 wherein the method treats at least one ruminal lactic acidosis, rumenitis, ruminal lactic acidosis induced laminitis, ruminal lactic acidosis induced bloat and liver abscesses.

9. A composition for the treatment of ruminal lactic acidosis comprising an effective amount of a bacterial culture according to claim 1 .

10. A composition of claim 9 , wherein the method treats at least one of ruminal lactic acidosis, rumenitis, ruminal lactic acidosis induced laminitis, ruminal lactic acidosis induced bloat and liver abscesses in ruminants.

11. A preparation for the treatment of ruminal lactic acidosis comprising an inoculum of a bacterial culture according to claim 1 and a sterile anaerobic growth medium.

12. The preparation of claim 11 wherein the culture and the medium are disposed in separate chambers of an anaerobic container, wherein the chambers are anaerobically connectable to each other.

13. The preparation of claim 12 , wherein the preparation treats at least one of ruminal lactic acidosis, rumenitis, ruminal lactic acidosis induced laminitis, ruminal lactic acidosis induced bloat and liver abscesses in ruminants.

14. A method of achieving in a ruminant at least one of increased milk production; improved growth rate; lower incidence of lactic acidosis and related diseases; in feeds; and the method comprising administering to the rumen of a ruminant an effective amount of the bacterial culture of claim 1 .

15. A method according to claim 14 wherein the culture is administered anaerobically.

Assignments (11)
RELEASE OF SECURITY INTEREST Recorded Feb 13, 2026
From: U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION (AS SUCCESSOR IN INTEREST TO U.S. BANK NATIONAL ASSOCIATION), AS ADMINISTRATIVE AGENT
To: AXIOTA U.S., INC. (F/K/A MS BIOTECH, INC.); WARBURTON TECHNOLOGY LIMITED
Reel/Frame 073791/0089 →
SECURITY INTEREST Recorded Feb 13, 2026
From: AXIOTA U.S., INC. (F/K/A MS BIOTECH, INC.)
To: ALTER DOMUS (US), LLC, AS ADMINISTRATIVE AGENT
Reel/Frame 073782/0124 →
(SECURITY INTEREST) GRANTOR'S NAME CHANGE Recorded Aug 7, 2023
From: MS BIOTECH, INC.
To: AXIOTA U.S., INC.
Reel/Frame 064506/0073 →
ASSIGNMENT AND ASSUMPTION AGREEMENT Recorded Mar 17, 2023
From: U.S. BANK NATIONAL ASSOCIATION
To: U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION
Reel/Frame 063115/0800 →
SECURITY INTEREST Recorded Dec 9, 2021
From: MS BIOTECH, INC.
To: U.S. BANK NATIONAL ASSOCIATION
Reel/Frame 058348/0833 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 17, 2010
From: KEMIRA PHOSPHATES (PTY) LIMITED
To: MS BIOTECH, INC.
Reel/Frame 024547/0274 →
CHANGE OF NAME Recorded May 21, 2009
From: MEGASTARTER, INC.
To: MS BIOTECH, INC.
Reel/Frame 022723/0040 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 21, 2009
From: YARA PHOSPHATES OY
To: MEGASTARTER, INC.
Reel/Frame 022721/0915 →
CHANGE OF NAME Recorded Nov 13, 2008
From: KEMIRA PHOSPHATES OY
To: YARA PHOSPHATES OY
Reel/Frame 021830/0145 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 22, 2006
From: KEMIRA PHOSPHARES (PTY) LIMITED
To: KEMIRA PHOSPHATES OY
Reel/Frame 017662/0674 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 22, 2006
From: HORN, CHARLES HENRY; KISTNER, ALBRECHT; GREYLING, BAREND JACOBUS; SMITH, ALEXANDRA HELENA
To: AGRICULTURAL RESEARCH COUNCIL; KEMIRA, PHOSPHATES (PTY) LIMITED
Reel/Frame 017662/0955 →
Priority Claims (1)
ZA 02/5742 · Jul 18, 2002 · national
Continuity (1)
Related Publication 20060257372A1 · Nov 16, 2006