IP Library Granted Patent US 12,066,370
Granted Patent B2
US 12,066,370 · App. 18/354,542 · Granted Aug 20, 2024

Flow cell carrier device

Inventors: Sandor Kovacs (Middletown, DE); Anson Hsu (San Diego, CA); David Baranson (Encinitas, CA); John Van Doorn (Fallbrook, CA); Eli N. Glezer (Del Mar, CA)
Assignee: Singular Genomics Systems, Inc.
G01N15/1404G01N15/147G01N2015/014G01N2015/1402G01N2015/1497
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Quick Facts
Patent No.
US 12,066,370
App. No.
18/354,542
Granted
Aug 20, 2024
Kind
B2
Abstract

The present disclosure relates to a flow cell carrier. The flow cell carrier may include a flow cell and a frame. The frame may include a pocket and a handle. The pocket may have at least one spring feature and at least one banking feature. The frame may be configured to retain the flow cell within the pocket such that a maximal surface area of the flow cell is exposed to an optical lens. Related methods and kits are also disclosed.

Claims (25)

1. A device comprising:

a reaction vessel comprising two or more channels; and

a frame, the frame comprising:

a handle;

a magnet wherein the magnet is at least one ferromagnetic pin;

wherein the frame is configured to retain the reaction vessel.

2. The device of claim 1 , wherein the frame further comprises a pocket, the pocket comprising at least one biasing feature.

3. The device of claim 2 , wherein the frame is configured to retain the reaction vessel within the pocket.

4. The device of claim 3 , wherein the frame is configured to retain the reaction vessel within the pocket such that a maximal surface area of the reaction vessel is available to be exposed to an optical lens.

5. The device of claim 1 , wherein the retaining of the reaction vessel within the pocket further comprises constraining a first, a second, a third, a fourth, a fifth, and a sixth degree of freedom of the reaction vessel.

6. The device of claim 1 , wherein the frame is an injection molded frame.

7. The device of claim 1 , wherein the handle is a raised handle.

8. The device of claim 1 , wherein the frame is further configured to provide a gap between a work surface and the reaction vessel.

9. The device of claim 2 , wherein the at least one biasing feature is a spring finger.

10. The device of claim 2 , wherein the at least one biasing feature is a tab.

11. The device of claim 1 , further comprising a microchip.

12. The device of claim 11 , wherein the microchip is an electronically erasable programmable read only memory (EEPROM) chip.

13. The device of claim 1 , wherein the reaction vessel comprises a plurality of inlet ports sized to receive a flow of one or more reagents and one or more enzymes for DNA amplification and a plurality of outlet ports that pass the flow of reagents out of the reaction vessel.

14. The device of claim 1 , wherein the reaction vessel comprises

a plurality of inlet ports sized to flow in the channel one or more reagents for DNA sequencing, and

a plurality of outlet ports that pass the flow of reagents out of the reaction vessel.

15. The device of claim 1 , wherein the device is configured to removably engage within a nucleic acid sequencing device.

16. The device of claim 1 , wherein the ferromagnetic pin comprises an alloy containing iron, cobalt, or nickel and a metalloid.

17. The device of claim 1 , wherein the reaction vessel comprises glass.

18. The device of claim 1 , wherein the two or more channels each comprise a polymer.

Assignments (3)
SECURITY INTEREST Recorded Mar 7, 2025
From: SINGULAR GENOMICS SYSTEMS, INC.
To: FIRST-CITIZENS BANK & TRUST COMPANY
Reel/Frame 070440/0465 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 27, 2024
From: KOVACS, SANDOR; HSU, ANSON; BARANSON, DAVID; VAN DOORN, JOHN; GLEZER, ELI N.
To: SINGULAR GENOMICS SYSTEMS, INC.
Reel/Frame 067864/0615 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 6, 2023
From: KOVACS, SANDOR; HSU, ANSON; BARANSON, DAVID
To: SINGULAR GENOMICS SYSTEMS, INC
Reel/Frame 065151/0594 →
Continuity (3)
Continuation 17105330 · Nov 25, 2020
Provisional Application 62952787 · Dec 23, 2019
Related Publication 20230384203A1 · Nov 30, 2023
Cited By (1)
US 12,442,729