Granted Patent B2

US 12,343,060 · App. 18/362,591 · Granted Jul 1, 2025

Inventors: Martin L. Mayse (Wayzata, MN); Steven C. Dimmer (Bellevue, WA)

Assignee: Nuvaira, Inc.

A61B18/082A61B17/00234A61B18/04A61B18/1492A61B18/18A61B18/1815A61N5/0601A61N5/062A61N5/1077A61N7/00A61N7/022A61B2017/00323A61B2018/0022A61B2018/00279A61B2018/00291A61B2018/00434A61B2018/00541A61B2018/00577A61B2018/00642A61B2018/00982A61B18/02A61B2018/0212A61B2018/1425A61B18/1477A61B2018/1861A61N2005/0604A61N2005/0651A61N2007/003

Abstract

Claims (32)

1. A method to denervate at least a portion of a bronchial tree, the method comprising:

providing an instrument to a user, the instrument including an energy emitter positioned at a distal section of the instrument; and

providing instructions to the user, the instructions comprising:

moving the energy emitter through a skin of a subject;

wrapping the distal section of the instrument around an airway of the bronchial tree of the subject to position the energy emitter with respect to nerve tissue along the airway of the bronchial tree;

energizing the energy emitter to damage the nerve tissue using energy from the energy emitter while the energy emitter is positioned outside of the airway; and

removing the instrument from the subject.

2. The method of claim 1 , wherein providing instructions to the user comprises providing instructions for use or directions for accessing instructions for use, the instructions for use or directions being recorded on a tangible medium.

3. The method of claim 1 , wherein the instructions further comprise monitoring the airway so as to leave the airway intact.

4. The method of claim 1 , wherein the instructions for energizing the energy emitter to damage the nerve tissue further comprise instructions for ablating a section of a nerve trunk to impede transmission of nervous system signals traveling along the airway.

5. The method of claim 1 , wherein the instructions for energizing the energy emitter to damage the nerve tissue further comprise delivering at least one of radiofrequency energy, microwave energy, radiation energy, high intensity focused ultrasound energy, and thermal energy from the energy emitter to damage the nerve tissue.

6. The method of claim 1 , wherein wrapping the distal section of the instrument around an airway of the bronchial tree of the subject to position the energy emitter with respect to nerve tissue along the airway of the bronchial tree further comprises delivering the energy emitter proximate to the nerve tissue prior to damaging the nerve tissue.

7. The method of claim 1 , wherein the instructions further comprise:

moving an intraluminal instrument through the subject's trachea and the airway; and

delivering energy between the energy emitter of the instrument outside the airway and the intraluminal instrument positioned within the airway to ablate the nerve tissue.

8. The method of claim 1 , wherein the instructions for energizing the energy emitter to damage the nerve tissue further comprise instructions for irreversibly damaging nerve tissue between the subject's trachea and the subject's lung to at least partially block a transmission of nervous system signals and to cause a permanent decrease in smooth muscle tone of the portion of a bronchial tree.

9. The method of claim 1 , wherein the instructions for energizing the energy emitter to damage the nerve tissue the nerve tissue further comprise instructions for ablating the nerve tissue while monitoring the airway so as not to pass the instrument through a wall of the airway.

10. The method of claim 1 , wherein the instructions for energizing the energy emitter to damage the nerve tissue further comprise instructions for destroying the nerve tissue while monitoring the airway so as not to substantially damage blood vessels of the airway.

11. The method of claim 1 , wherein the instructions for energizing the energy emitter to damage nerve tissue further comprise instructions for damaging nerve tissue positioned along a main bronchus of the bronchial tree.

12. The method of claim 1 , wherein the instructions further comprise visualizing the outside of the airway while positioning the energy emitter using a visualization device selected from a group consisting of a thoracoscope, an ultrasonic device, and a fluoroscopy system.

13. The method of claim 1 , wherein the instructions for moving the energy emitter through the skin of a subject further comprise moving the energy emitter through a port, a cannula, or a sleeve extending through the skin of the subject.

14. A method to denervate at least a portion of a bronchial tree, the method comprising:

providing an instrument to a user; and

providing instructions to the user, the instructions comprising:

percutaneously delivering a distal section of the instrument through a skin of a subject and wrapping the distal section of the instrument around an airway of a bronchial tree of the subject such that the distal section is positioned to damage nerve tissue of the bronchial tree; and

delivering energy to a first portion of the bronchial tree using the instrument to substantially inhibit nervous system signals from traveling to a second portion of the bronchial tree.

15. The method of claim 14 , wherein providing instructions to the user comprises providing instructions for use or directions for accessing instructions for use, the instructions for use or directions being recorded on a tangible medium.

16. The method of claim 14 , wherein the instructions further comprise damaging a nerve trunk positioned along a main bronchus.

17. The method of claim 14 , wherein the instructions for denervating the first portion of the bronchial tree further comprise instructions for damaging nerve tissue positioned between the subject's trachea and lung.

18. The method of claim 14 , wherein the instructions for denervating the first portion of the bronchial tree further comprise instructions for ablating a sufficient amount of nerve tissue to prevent nervous system signals from traveling to substantially all bronchial branches of the bronchial tree.

19. The method of claim 14 , wherein the instructions for denervating the first portion of the bronchial tree further comprise instructions for removing the instrument without destroying the airway.

20. The method of claim 14 , wherein the instructions for percutaneously delivering a distal section of the instrument through the skin of a subject further comprise instructions for delivering a distal section of the instrument through a port, a cannula, or a sleeve extending through the subject's skin.

Assignments (3)

Continuity (6)

References Cited (400)