USE OF MALTODEXTRIN AS AN EXCIPIENT
The present invention relates to the use of maltodextrin as an excipient. In particular, the present invention relates to the use of maltodextrin as an excipient in probiotic formulations. The present invention also relates to a method to provide a probiotics formulation with improved dispersibility and/or shelf life comprising adding maltodextrin to probiotic formulations.
1 - 6 . (canceled)
7 . The method according to claim 11 , wherein the maltodextrin is further combined with a base.
8 . The method according to claim 7 , wherein the base is selected from Sodium hydroxide (NaOH), Potassium hydroxide (KOH) or Ammonium hydroxide (NH 4 OH).
9 - 10 . (canceled)
11 . A method to improve shelf life of freeze-dried probiotic bacteria comprising:
blending maltodextrin with the freeze-dried probiotic bacteria to form a blend, and
storing the blend,
wherein said maltodextrin has a dextrose equivalent (DE) between 17 and 23 and a water activity (AW) below 0.1.
12 . (canceled)
13 . The method according to claim 11 , wherein the freeze-dried probiotic bacteria comprises Lactobacillus acidophilus.
14 . The method according to claim 11 , wherein the freeze-dried probiotic bacteria comprises Bifidobacterium lactis.
15 . A method for improving shelf-life of a probiotic formulation comprising freeze-dried probiotic bacteria comprising:
adding maltodextrin to the formulation, and
storing the formulation,
wherein:
the formulation is in powder form, and
the maltodextrin has a dextrose equivalent (DE) between 17 and 23 and a water activity (AW) below 0.1.
16 . The method according to claim 11 wherein the maltodextrin is potato maltodextrin.
17 - 18 . (canceled)
19 . The method according to claim 15 , wherein the maltodextrin is potato maltodextrin.
20 . The method according to claim 15 , wherein the freeze-dried probiotic bacteria comprises Lactobacillus acidophilus.
21 . The method according to claim 15 , wherein the freeze-dried probiotic bacteria comprises Bifidobacterium lactis.
22 . The method according to claim 15 , wherein the method further comprises adding a base to the formulation.
23 . The method according to claim 22 , wherein the base is selected from Sodium hydroxide (NaOH), Potassium hydroxide (KOH) or Ammonium hydroxide (NH 4 OH).
24 . The method according to claim 15 , wherein the maltodextrin has a dextrose equivalent (DE) between 17 and 20.
25 . The method according to claim 15 , wherein the maltodextrin has a dextrose equivalent (DE) between 18 and 20.
26 . The method according to claim 15 , wherein the maltodextrin has a dextrose equivalent (DE) between 19 and 20.
27 . The method according to claim 15 , wherein the maltodextrin has a water activity (AW) below 0.09.
28 . The method according to claim 11 , wherein:
the freeze-dried probiotic bacteria comprises Lactobacillus acidophilus;
the maltodextrin comprises potato maltodextrin; and
the maltodextrin is further combined with a base selected from sodium hydroxide (NaOH), potassium hydroxide (KOH) and ammonium hydroxide (NH 4 OH).
29 . The method according to claim 11 , wherein:
the freeze-dried probiotic bacteria comprises Bifidobacterium lactis;
the maltodextrin comprises potato maltodextrin; and
the maltodextrin is further combined with a base selected from sodium hydroxide (NaOH), potassium hydroxide (KOH) and ammonium hydroxide (NH 4 OH).
30 . The method according to claim 15 , wherein:
the freeze-dried probiotic bacteria comprises Lactobacillus acidophilus;
the maltodextrin comprises potato maltodextrin; and
the maltodextrin is further combined with a base selected from sodium hydroxide (NaOH), potassium hydroxide (KOH) and ammonium hydroxide (NH 4 OH).
31 . The method according to claim 15 , wherein:
the freeze-dried probiotic bacteria comprises Bifidobacterium lactis;
the maltodextrin comprises potato maltodextrin; and
the maltodextrin is further combined with a base selected from sodium hydroxide (NaOH), potassium hydroxide (KOH) and ammonium hydroxide (NH 4 OH).