IP Library › Patent Application 18368042
Patent Application
App. No. 18/368,042

FORMULATIONS AND METHODS FOR PULMONARY DELIVERY OF ACTIVE PHARMACEUTICAL INGREDIENTS

Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US None
App. No.
18/368,042
Abstract

An aerosolizable liquid formulation for inhalation includes one or more active pharmaceutical ingredients dissolved in a solvent. The one or more active pharmaceutical ingredients includes a vasodilator active pharmaceutical ingredient and, optionally, non-vasodilator active pharmaceutical ingredient.

Claims (18)

1 - 28 . (canceled)

29 . A method of administering an aerosolizable and inhalable pharmaceutical complex to a patient comprising the steps of:

providing a first cartridge housing a first liquid formulation that includes a vasodilator active pharmaceutical ingredient;

providing a second cartridge housing a second liquid formulation that includes a non-vasodilator pharmaceutical ingredient;

aerosolizing the first liquid formulation using an electronic device to facilitate inhalation and pulmonary delivery of the vasodilator active pharmaceutical ingredient, thereby increasing oxygenation in a blood flow of the patient; and

after increasing oxygenation in the blood flow, aerosolizing the second liquid formulation using the electronic device to facilitate inhalation and pulmonary delivery of the non-vasodilator active pharmaceutical ingredient.

30 . The method of claim 29 , wherein at least one of the first and second liquid formulations is in an aqueous form.

31 . The method of claim 29 , wherein at least one of the first and second liquid formulations is in a nanoemulsion form.

32 - 39 . (canceled)

40 . A method of administering an aerosolizable and inhalable pharmaceutical complex to a patient comprising the steps of:

providing a first cartridge housing a first liquid formulation that includes an active pharmaceutical ingredient that exhibits a first particle size distribution;

providing a second cartridge housing a second liquid formulation that includes an active pharmaceutical ingredient that exhibits a second particle size distribution different than the first particle size distribution;

aerosolizing the first liquid formulation using an electronic device; and

after aerosolizing the first liquid formulation, aerosolizing the second liquid formulation.

41 . The method of claim 40 , wherein the active pharmaceutical ingredient of the first liquid formulation and the active pharmaceutical ingredient of the second liquid formulation include a common active pharmaceutical ingredient.

42 . The method of claim 41 , wherein the common active pharmaceutical ingredient includes povidone-iodine.

43 . The method of claim 42 , wherein the first liquid formulation exhibits a generally turbulent flow upon aerosolization.

44 . The method of claim 42 , wherein the second liquid formulation exhibits a generally laminar flow upon aerosolization.