HMOX1 inducers
The present invention is related to compounds of structure (I) as heme oxygenase 1 (HMOX 1) inducers. (Formula I) The present invention is also related a method of controlling the activity or the amount, or both the activity and the amount, of heme-oxygenase 1 in a mammalian subject. The definitions of the variables are provided herein.
1. A compound represented by structural formula (III-B):
or a pharmaceutically acceptable salt thereof, wherein
R 1 is —C(═O)NH((C 1 -C 4 )hydroxyalkoxy(C 1 -C 4 )alkyl), —C(═O)NH(hydroxy(C 1 -C 4 )alkyl), —C(═O)NH(methoxy(C 1 -C 4 )alkyl), or —C(═O)NH(hydroxy(C 1 -C 4 )alkoxy); and
R 2 is OCH 2 CH 2 OCH 3 .
2. A compound represented by structural formula (III-B):
or a pharmaceutically acceptable salt thereof, wherein
R 1 is —C(═O)NH(C 1 -C 4 )alkyl optionally substituted with —OH, —NH 2 , —(C 1 -C 4 )-alkoxy, or —(C 1 -C 4 )hydroxyalkoxy, and
R 2 is OCH 2 CH 2 OCH 3 .
3. The compound of claim 2 , or a pharmaceutically acceptable salt thereof, wherein
R 1 is —C(═O)NH(C 1 -C 4 )alkyl substituted with —(C 1 -C 4 )-alkoxy, and
R 2 is OCH 2 CH 2 OCH 3 .
4. A compound, or a pharmaceutically acceptable salt thereof, wherein the compound is:
5. The compound, or a pharmaceutically acceptable salt thereof, of claim 4 , wherein the compound is
6. The compound, or a pharmaceutically acceptable salt thereof, of claim 4 , wherein the compound is
7. The compound, or a pharmaceutically acceptable salt thereof, of claim 4 , wherein the compound is
8. The compound, or a pharmaceutically acceptable salt thereof, of claim 4 , wherein the compound is
9. A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and the compound of claim 1 , or a pharmaceutically acceptable salt thereof.
10. A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and the compound of claim 2 , or a pharmaceutically acceptable salt thereof.
11. A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and the compound of claim 4 , or a pharmaceutically acceptable salt thereof.