Prosthetic heart valves
Prosthetic heart valves may be delivered to a targeted native heart valve site via one or more delivery catheters. In some embodiments, the prosthetic heart valves are implanted using catheter-based deployment systems that include multiple control wires. In particular implementations, the deployment systems can include a retrieval catheter that can be used to recapture the prosthetic heart valve back into a delivery sheath after being expressed from the delivery sheath. The prosthetic heart valves occupy a small delivery profile, thereby facilitating a smaller delivery catheter system for advancement to the heart. Some delivery catheter systems can include a curved control catheter and/or a deflectable catheter to facilitate deployment of the prosthetic heart valve to a native tricuspid valve site via a superior vena cava or inferior vena cava.
1. A prosthetic valve system comprising:
a prosthetic heart valve comprising:
a main body including an inflow end portion and an outflow end portion, the main body defining a central axis extending between the inflow and outflow end portions;
one or more anterior flaps extending from the outflow end portion in a first direction that is transverse to the central axis; and
a posterior flap extending from the outflow end portion in a second direction that is transverse to the central axis; and
a valve deployment system comprising:
an elongate control catheter defining one or more lumens;
a first control wire slidably disposed in the one or more lumens and releasably coupled to the inflow end portion, wherein the first control wire comprises a first wire loop that extends out of the one or more lumens and that is releasably coupled to the inflow end portion;
a second control wire slidably disposed in the one or more lumens and releasably coupled to the outflow end portion;
a third control wire slidably disposed in the one or more lumens and releasably coupled to the one or more anterior flaps; and
a fourth control wire slidably disposed in the one or more lumens and releasably coupled to the posterior flap.
2. The prosthetic valve system of claim 1 , wherein the second control wire comprises a second wire loop that extends out of the one or more lumens and that is releasably coupled to the outflow end portion.
3. The prosthetic valve system of claim 1 , wherein the fourth control wire comprises a fourth wire loop that extends out of the one or more lumens and that is releasably coupled to the outflow end portion.
4. The prosthetic valve system of claim 1 , wherein the third control wire comprises a single wire segment that extends out of the one or more lumens, releasably couples with the one or more anterior flaps, and terminates in releasable engagement with a distal tip portion of the control catheter.
5. The prosthetic valve system of claim 1 , wherein the valve deployment system further comprises a deflectable catheter defining a lumen, and wherein a portion of the control catheter is slidably disposable within the lumen of the deflectable catheter, and wherein a distal end portion of the deflectable catheter is selectively deflectable by manipulating a user control mechanism coupled to a proximal end of the valve deployment system.
6. The prosthetic valve system of claim 5 , wherein the valve deployment system further comprises a fifth control wire slidably coupled with the deflectable catheter.
7. The prosthetic valve system of claim 6 , wherein the prosthetic heart valve further comprises a posterior arm extending from the inflow end portion of the main body, and wherein the fifth control wire comprises a single wire segment that releasably couples with the posterior arm and terminates in releasable engagement with a distal tip portion of the deflectable catheter.
8. A prosthetic valve system comprising:
a prosthetic heart valve comprising:
a main body including an inflow end portion and an outflow end portion, the main body defining a central axis extending between the inflow and outflow end portions;
one or more anterior flaps extending from the outflow end portion in a first direction that is transverse to the central axis; and
a posterior flap extending from the outflow end portion in a second direction that is transverse to the central axis; and
a valve deployment system comprising:
an elongate control catheter defining one or more lumens;
a first control wire slidably disposed in the one or more lumens and releasably coupled to the inflow end portion;
a second control wire slidably disposed in the one or more lumens and releasably coupled to the outflow end portion, wherein the second control wire comprises a second wire loop that extends out of the one or more lumens and that is releasably coupled to the outflow end portion;
a third control wire slidably disposed in the one or more lumens and releasably coupled to the one or more anterior flaps; and
a fourth control wire slidably disposed in the one or more lumens and releasably coupled to the posterior flap.
9. The prosthetic valve system of claim 8 , wherein the first control wire comprises a first wire loop that extends out of the one or more lumens and that is releasably coupled to the inflow end portion.
10. The prosthetic valve system of claim 8 , wherein the fourth control wire comprises a fourth wire loop that extends out of the one or more lumens and that is releasably coupled to the outflow end portion.
11. The prosthetic valve system of claim 8 , wherein the third control wire comprises a single wire segment that extends out of the one or more lumens, releasably couples with the one or more anterior flaps, and terminates in releasable engagement with a distal tip portion of the control catheter.
12. The prosthetic valve system of claim 8 , wherein the valve deployment system further comprises a deflectable catheter defining a lumen, and wherein a portion of the control catheter is slidably disposable within the lumen of the deflectable catheter, and wherein a distal end portion of the deflectable catheter is selectively deflectable by manipulating a user control mechanism coupled to a proximal end of the valve deployment system.
13. The prosthetic valve system of claim 12 , wherein the valve deployment system further comprises a fifth control wire slidably coupled with the deflectable catheter, wherein the prosthetic heart valve further comprises a posterior arm extending from the inflow end portion of the main body, and wherein the fifth control wire comprises a single wire segment that releasably couples with the posterior arm and terminates in releasable engagement with a distal tip portion of the deflectable catheter.
14. A prosthetic valve system comprising:
a prosthetic heart valve comprising:
a main body including an inflow end portion and an outflow end portion, the main body defining a central axis extending between the inflow and outflow end portions;
one or more anterior flaps extending from the outflow end portion in a first direction that is transverse to the central axis; and
a posterior flap extending from the outflow end portion in a second direction that is transverse to the central axis; and
a valve deployment system comprising:
an elongate control catheter defining one or more lumens;
a first control wire slidably disposed in the one or more lumens and releasably coupled to the inflow end portion;
a second control wire slidably disposed in the one or more lumens and releasably coupled to the outflow end portion;
a third control wire slidably disposed in the one or more lumens and releasably coupled to the one or more anterior flaps; and
a fourth control wire slidably disposed in the one or more lumens and releasably coupled to the posterior flap, wherein the fourth control wire comprises a fourth wire loop that extends out of the one or more lumens and that is releasably coupled to the outflow end portion.
15. The prosthetic valve system of claim 14 , wherein the first control wire comprises a first wire loop that extends out of the one or more lumens and that is releasably coupled to the inflow end portion.
16. The prosthetic valve system of claim 14 , wherein the second control wire comprises a second wire loop that extends out of the one or more lumens and that is releasably coupled to the outflow end portion.
17. The prosthetic valve system of claim 14 , wherein the third control wire comprises a single wire segment that extends out of the one or more lumens, releasably couples with the one or more anterior flaps, and terminates in releasable engagement with a distal tip portion of the control catheter.
18. The prosthetic valve system of claim 14 , wherein the valve deployment system further comprises a deflectable catheter defining a lumen, and wherein a portion of the control catheter is slidably disposable within the lumen of the deflectable catheter, and wherein a distal end portion of the deflectable catheter is selectively deflectable by manipulating a user control mechanism coupled to a proximal end of the valve deployment system.
19. The prosthetic valve system of claim 18 , wherein the valve deployment system further comprises a fifth control wire slidably coupled with the deflectable catheter, wherein the prosthetic heart valve further comprises a posterior arm extending from the inflow end portion of the main body, and wherein the fifth control wire comprises a single wire segment that releasably couples with the posterior arm and terminates in releasable engagement with a distal tip portion of the deflectable catheter.
20. A prosthetic valve system comprising:
a prosthetic heart valve comprising:
a main body including an inflow end portion and an outflow end portion, the main body defining a central axis extending between the inflow and outflow end portions;
one or more anterior flaps extending from the outflow end portion in a first direction that is transverse to the central axis; and
a posterior flap extending from the outflow end portion in a second direction that is transverse to the central axis; and
a valve deployment system comprising:
an elongate control catheter defining one or more lumens;
a first control wire slidably disposed in the one or more lumens and releasably coupled to the inflow end portion;
a second control wire slidably disposed in the one or more lumens and releasably coupled to the outflow end portion;
a third control wire slidably disposed in the one or more lumens and releasably coupled to the one or more anterior flaps, wherein the third control wire comprises a single wire segment that extends out of the one or more lumens, releasably couples with the one or more anterior flaps, and terminates in releasable engagement with a distal tip portion of the control catheter; and
a fourth control wire slidably disposed in the one or more lumens and releasably coupled to the posterior flap.
21. The prosthetic valve system of claim 20 , wherein the first control wire comprises a first wire loop that extends out of the one or more lumens and that is releasably coupled to the inflow end portion.
22. The prosthetic valve system of claim 20 , wherein the second control wire comprises a second wire loop that extends out of the one or more lumens and that is releasably coupled to the outflow end portion.
23. The prosthetic valve system of claim 20 , wherein the fourth control wire comprises a fourth wire loop that extends out of the one or more lumens and that is releasably coupled to the outflow end portion.
24. The prosthetic valve system of claim 20 , wherein the valve deployment system further comprises a deflectable catheter defining a lumen, and wherein a portion of the control catheter is slidably disposable within the lumen of the deflectable catheter, and wherein a distal end portion of the deflectable catheter is selectively deflectable by manipulating a user control mechanism coupled to a proximal end of the valve deployment system.
25. The prosthetic valve system of claim 24 , wherein the valve deployment system further comprises a fifth control wire slidably coupled with the deflectable catheter, wherein the prosthetic heart valve further comprises a posterior arm extending from the inflow end portion of the main body, and wherein the fifth control wire comprises a single wire segment that releasably couples with the posterior arm and terminates in releasable engagement with a distal tip portion of the deflectable catheter.
26. A prosthetic valve system comprising:
a prosthetic heart valve comprising:
a main body including an inflow end portion and an outflow end portion, the main body defining a central axis extending between the inflow and outflow end portions;
one or more anterior flaps extending from the outflow end portion in a first direction that is transverse to the central axis; and
a posterior flap extending from the outflow end portion in a second direction that is transverse to the central axis; and
a valve deployment system comprising:
an elongate control catheter defining one or more lumens;
a first control wire slidably disposed in the one or more lumens and releasably coupled to the inflow end portion;
a second control wire slidably disposed in the one or more lumens and releasably coupled to the outflow end portion;
a third control wire slidably disposed in the one or more lumens and releasably coupled to the one or more anterior flaps;
a fourth control wire slidably disposed in the one or more lumens and releasably coupled to the posterior flap;
a deflectable catheter defining a lumen, wherein a portion of the control catheter is slidably disposable within the lumen of the deflectable catheter, and wherein a distal end portion of the deflectable catheter is selectively deflectable by manipulating a user control mechanism coupled to a proximal end of the valve deployment system; and
a fifth control wire slidably coupled with the deflectable catheter.
27. The prosthetic valve system of claim 26 , wherein the first control wire comprises a first wire loop that extends out of the one or more lumens and that is releasably coupled to the inflow end portion.
28. The prosthetic valve system of claim 26 , wherein the second control wire comprises a second wire loop that extends out of the one or more lumens and that is releasably coupled to the outflow end portion.
29. The prosthetic valve system of claim 26 , wherein the fourth control wire comprises a fourth wire loop that extends out of the one or more lumens and that is releasably coupled to the outflow end portion.
30. The prosthetic valve system of claim 26 , wherein the third control wire comprises a single wire segment that extends out of the one or more lumens, releasably couples with the one or more anterior flaps, and terminates in releasable engagement with a distal tip portion of the control catheter.
31. The prosthetic valve system of claim 26 , wherein the prosthetic heart valve further comprises a posterior arm extending from the inflow end portion of the main body, and wherein the fifth control wire comprises a single wire segment that releasably couples with the posterior arm and terminates in releasable engagement with a distal tip portion of the deflectable catheter.