IP Library › Granted Patent US 12,186,595
Granted Patent B2
US 12,186,595 · App. 18/386,910 · Granted Jan 7, 2025

Ultrasound therapy system

Inventors: Azita Soltani (Snohomish, WA); Adrian F. Prokop (Seattle, WA)
Assignee: BOSTON SCIENTIFIC SCIMED, INC.
A61N7/022A61B17/2202A61M25/0032A61M37/0092A61B2017/22088A61B2017/22089A61M25/003Y10T29/49826
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Quick Facts
Patent No.
US 12,186,595
App. No.
18/386,910
Granted
Jan 7, 2025
Kind
B2
Abstract

In one embodiment of the present invention, a system for treating an occlusion within a patient's vasculature with ultrasonic energy comprises a catheter configured to be passed through the patient's vasculature such that a portion of the catheter is positioned at an intravascular treatment site. The system further comprises an ultrasound radiating member, an ultrasound signal generator configured to supply a drive signal to the ultrasound radiating member, an infusion pump configured to pump a therapeutic compound into the fluid delivery lumen so as to cause the therapeutic compound to be delivered to the treatment site and a controller configured to control the ultrasound signal generator and the infusion pump.

Claims (28)

1. A method of treating a vascular occlusion, the method comprising:

positioning an ultrasound catheter within a patient, the ultrasound catheter including a treatment zone, an ultrasound radiating member positioned within the treatment zone, and a fluid delivery lumen hydraulically coupled to an exit port within the treatment zone;

delivering, through the fluid delivery lumen and the exit port, a microbubble therapeutic compound to an internal portion of the vascular occlusion, the microbubble therapeutic compound having microbubbles with an average diameter in a range of 0.01 μm to 0.4 μm, wherein the microbubble therapeutic compound is selected from the group consisting of neuroprotection compounds, anti-thrombosis compounds, heparin, urokinase, streptokinase, tissue plasminogen activator (tPA), and recombinant tissue plasminogen activator (rtPA); and

delivering ultrasonic energy to the vascular occlusion, wherein the ultrasonic energy causes cavitation to occur within the microbubble therapeutic compound delivered to the vascular occlusion.

2. The method of claim 1 , wherein the average diameter of the microbubbles is in the range of 0.01 μm to 0.1 μm.

3. The method of claim 1 , wherein the microbubble therapeutic compound has a microbubble concentration in the range of 4×107 to 10×109 microbubbles per milliliter.

4. The method of claim 1 , wherein the microbubble therapeutic compound is at an infusion rate that is in the range of 10 mL per hour to 120 mL per hour.

5. The method of claim 1 , wherein the microbubble therapeutic compound is delivered at an infusion rate that is in the range of 100 mL per hour to 120 mL per hour.

6. The method of claim 1 , wherein the microbubble therapeutic compound is delivered to the vascular occlusion prior to delivering ultrasound energy to the vascular occlusion.

7. The method of claim 1 , wherein a first portion of the microbubble therapeutic compound is delivered to the vascular occlusion prior to delivering ultrasound energy to the vascular occlusion, and a second portion of the microbubble therapeutic compound is delivered to the vascular occlusion after delivering ultrasound energy to the vascular occlusion is started.

8. The method of claim 1 , wherein the microbubble therapeutic compound is delivered to the vascular occlusion simultaneous with delivering ultrasound energy to the vascular occlusion.

9. The method of claim 1 , wherein the microbubble therapeutic compound is delivered to the vascular occlusion only when the ultrasound energy is being delivered to the vascular occlusion.

10. The method of claim 1 , further comprising positioning the ultrasound catheter within a patient's vasculature such that at least a portion of the treatment zone is located in the internal portion of the vascular occlusion.

11. The method of claim 1 , wherein an exterior surface of the treatment zone includes a cavitation promoting surface.

12. The method of claim 11 , wherein the cavitation promoting surface is patterned with features from an ablative laser.

13. The method of claim 1 , wherein delivering ultrasonic energy to the vascular occlusion causes stable cavitation to occur without causing substantial inertial cavitation.

14. The method of claim 1 , wherein the microbubble therapeutic compound comprises microbubbles infused with a drug.

15. The method of claim 1 , wherein the microbubble therapeutic compound comprises octafluoropropane encapsulated in a plurality of lipid shells.

16. A method of treating a vascular occlusion, the method comprising:

positioning an ultrasound catheter within a patient, the ultrasound catheter including a treatment zone, an ultrasound radiating member positioned within the treatment zone, and a fluid delivery lumen hydraulically coupled to an exit port within the treatment zone;

delivering, through the fluid delivery lumen and the exit port, a microbubble therapeutic compound to an internal portion of the vascular occlusion at an infusion rate that is in a range of 100 mL per hour to 120 mL per hour, the microbubble therapeutic compound having microbubbles with an average diameter in a range of 0.01 μm to 0.4 μm, wherein the microbubble therapeutic compound is selected from the group consisting of neuroprotection compounds, anti-thrombosis compounds, heparin, urokinase, streptokinase, tissue plasminogen activator (tPA), and recombinant tissue plasminogen activator (rtPA); and

delivering ultrasonic energy to the vascular occlusion, wherein the ultrasonic energy causes cavitation to occur within the microbubble therapeutic compound delivered to the vascular occlusion.

17. The method of claim 16 , wherein the microbubble therapeutic compound has a microbubble concentration in the range of 8×106 to 12×109 microbubbles per milliliter.

18. The method of claim 16 , wherein the average diameter of the microbubbles is in the range of 0.01 μm to 0.1 μm.

19. A system for treating a vascular occlusion, the system comprising:

an ultrasound catheter designed to be positioned within a patient, the ultrasound catheter including a treatment zone, an ultrasound radiating member positioned within the treatment zone, and a fluid delivery lumen hydraulically coupled to an exit port within the treatment zone, the ultrasound catheter configured for delivering ultrasonic energy to the vascular occlusion; and

a microbubble therapeutic compound configured for delivery through the fluid delivery lumen and the exit port, to an internal portion of the vascular occlusion, the microbubble therapeutic compound having microbubbles with an average diameter in a range of 0.01 μm to 0.4 μm, wherein the microbubble therapeutic compound is selected from the group consisting of neuroprotection compounds, anti-thrombosis compounds, heparin, urokinase, streptokinase, tissue plasminogen activator (tPA), and recombinant tissue plasminogen activator (rtPA).

20. The system of claim 19 , wherein the microbubble therapeutic compound has a microbubble concentration in the range of 4×107 to 12×109 microbubbles per milliliter.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 9, 2024
From: SOLTANI, AZITA; PROKOP, ADRIAN F.
To: EKOS CORPORATION
Reel/Frame 067042/0190 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 9, 2024
From: EKOS LLC
To: BOSTON SCIENTIFIC SCIMED, INC.
Reel/Frame 067042/0823 →
CHANGE OF NAME Recorded Apr 9, 2024
From: EKOS CORPORATION
To: EKOS LLC
Reel/Frame 067043/0077 →
Continuity (7)
Continuation 17374524 · Jul 13, 2021
Continuation 16268075 · Feb 5, 2019
Continuation 13176613 · Jul 5, 2011
Division 11739629 · Apr 24, 2007
Provisional Application 60799119 · May 9, 2006
Provisional Application 60794330 · Apr 24, 2006
Related Publication 20240058627A1 · Feb 22, 2024
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