Granted Patent
B2
US 12,545,663 · App. 18/390,494 · Granted Feb 10, 2026
Small molecule modulators of pantothenate kinases
Inventors:
Richard E. Lee (Cordova, TN); Rajendra P. Tangallapally (Collierville, TN); Charles O. Rock (Bartlett, TN); Suzanne Jackowski (Bartlett, TN); Anne V. Edwards (Memphis, TN); Mi Kyung Yun (Collierville, TN); Chitra Subramanian (Cordova, TN); Robert Zamboni (Beaconsfield, CA); T. Jagadeeswar Reddy (Pierrefonds, CA)
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Abstract
The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Claims (16)
1 . A method of modulating pantothenate kinase activity in a cell, the method comprising contacting at least one cell with an effective amount of a compound of the formula
or a pharmaceutically acceptable salt thereof.
2 . The method of claim 1 , wherein modulating is inhibiting.
3 . The method of claim 2 , wherein the cell is involved in a pathology characterized by heteromorphism of a gene associated with pantothenate kinase enzyme.
4 . The method of claim 2 , wherein the cell is involved in a pathology characterized by misregulation of expression of a gene associated with pantothenate kinase enzyme.
5 . The method of claim 1 , wherein modulating is activating.
6 . The method of claim 5 , wherein the cell is involved in a pathology characterized by heteromorphism of a gene associated with pantothenate kinase enzyme.
7 . The method of claim 5 , wherein the cell is involved in a pathology characterized by misregulation of expression of a gene associated with pantothenate kinase enzyme.
8 . A method of therapeutically treating a disorder associated with pantothenate kinase activity in a subject, the method comprising administering to the subject an effective amount of a compound of the formula
or a pharmaceutically acceptable salt thereof.
9 . The method of claim 8 , further comprising administering to the subject an effective amount of pantothenate and/or pantothenic acid.
10 . The method of claim 8 , wherein the disorder associated with pantothenate kinase activity is hyperglycemia caused by misregulated and/or elevated coenzyme A.
11 . The method of claim 8 , wherein the disorder associated with pantothenate kinase activity is neurodegeneration caused by a deficiency of pantothenate kinase or coenzyme A.
12 . The method of claim 8 , wherein the disorder associated with pantothenate kinase activity is neurodegeneration characterized by brain iron accumulation or neurological disorder characterized by reduced mitochondrial function.
13 . The method of claim 8 , wherein the disorder associated with pantothenate kinase activity is selected from dystonia, extrapyramidal effects, dysphagia, muscle rigidity and/or limb stiffness, choreoathetosis, tremor, dementia, spasticity, muscle weakness, or seizure.
14 . The method of claim 11 , wherein the neurodegeneration is pantothenate kinase-associated neurodegeneration (PKAN).
Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 8, 2025
From: COA THERAPEUTICS, INC.
To: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
Reel/Frame 071065/0586 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 13, 2024
From: LEE, RICHARD E.; TANGALLAPALLY, RAJENDRA P.; ROCK, CHARLES O.; JACKOWSKI, SUZANNE; EDWARDS, ANNE V.; YUN, MI KYUNG; SUBRAMANIAN, CHITRA
To: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
Reel/Frame 069583/0249 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 13, 2024
From: ZAMBONI, ROBERT; REDDY, T. JAGADEESWAR
To: COA THERAPEUTICS, INC.
Reel/Frame 069583/0276 →
Continuity (3)
Continuation
16958022
Provisional Application
62610835
· Dec 27, 2017
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