IP Library Granted Patent US 12,502,368
Granted Patent B2
US 12,502,368 · App. 18/403,027 · Granted Dec 23, 2025

Treatment and diagnosis of melanoma

Inventors: Sohail F. Tavazoie (New York, NY); Nora Pencheva (New York, NY)
Assignee: THE ROCKEFELLER UNIVERSITY
A61K31/195A61K31/136A61K31/18A61K31/265A61K31/415A61K31/4155A61K31/416A61K31/4164A61K31/4174A61K31/47A61K31/5377A61K31/675A61K38/1709A61K38/177A61K45/06C07C217/54C07D233/64C07F9/6506C12Q1/6886G01N33/5743C12Q2600/118C12Q2600/136C12Q2600/158C12Q2600/178G01N2500/10
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Quick Facts
Patent No.
US 12,502,368
App. No.
18/403,027
Granted
Dec 23, 2025
Kind
B2
Abstract

The present invention discloses novel agents and methods for diagnosis and treatment of melanoma. Also disclosed are related arrays, kits, and screening methods.

Claims (24)

1 . A method of treating a cancer in a subject in need thereof, comprising administering to the subject an effective amount of an LXRβ agonist selected from the group consisting of:

or a pharmaceutically acceptable salt thereof, and

a PD-1 inhibitor or a PD-L1 inhibitor.

2 . The method of claim 1 , further comprising administering to the subject one or more chemotherapeutic agents or cytotoxic agents.

3 . The method of claim 2 , wherein the one or more chemotherapeutic agents comprise

a platinum agent and a cytotoxic agent.

4 . The method of claim 2 , wherein the one or more chemotherapeutic agents are selected from the group consisting of platinum agent, pemetrexed, paclitaxel, taxol, docetaxel, and taxotere.

5 . The method of claim 3 , wherein the platinum agent is selected from the group consisting of spiroplatin, tetraplatin, ormaplatin, iproplatin, oxaliplatin, carboplatin, lobaplatin, satraplatin, and cisplatin.

6 . The method of claim 3 , wherein the one or more chemotherapeutic agents are platinum agent and paclitaxel.

7 . The method of claim 3 , wherein the one or more chemotherapeutic agents are platinum agent and pemetrexed.

8 . The method of claim 1 , wherein the PD-1 inhibitor is nivolumab.

9 . The method of claim 1 , wherein the PD-L1 inhibitor is MPDL3280A.

10 . The method of claim 1 , wherein the LXRβ agonist is compound 25.

11 . The method of claim 1 , which is prior to other anti-cancer therapy.

12 . The method of claim 1 , which is subsequent to a prior anti-cancer therapy.

13 . The method of claim 1 , wherein the cancer is non-small cell lung cancer.

14 . The method of claim 1 , wherein the cancer is endometrial cancer or lung cancer.

15 . The method of claim 1 , wherein the cancer is resistant to a PD-1 inhibitor or a PD-L1 inhibitor.

16 . The method of claim 1 , wherein the cancer is metastatic cancer.

17 . The method of claim 1 , wherein the cancer is cell migration cancer.

18 . The method of claim 1 , wherein the cancer is non-metastatic cell migration cancer.

19 . The method of claim 1 , wherein the cancer spreads via seeding the surface of peritoneal, pleural, pericardial, or subarachnoid spaces of the subject.

20 . The method of claim 1 , wherein the migrating cancer spreads via lymphatic system, or spread hematogenously.

21 . The method of claim 1 , wherein the LXRβ agonist or the pharmaceutically acceptable salt thereof is in an amount sufficient to reduce tumor seeding.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 11, 2025
From: TAVAZOIE, SOHAIL; PENCHEVA, NORA
To: THE ROCKEFELLER UNIVERSITY
Reel/Frame 072221/0929 →
Continuity (10)
Division 17201493 · Mar 15, 2021
Division 16725493 · Dec 23, 2019
Continuation 15881231 · Jan 26, 2018
Continuation 15650480 · Jul 14, 2017
Continuation 15228643 · Aug 4, 2016
Continuation 14486477 · Sep 15, 2014
Continuation PCTUS2013054690 · Aug 13, 2013
Provisional Application 61784057 · Mar 14, 2013
Provisional Application 61682339 · Aug 13, 2012
Related Publication 20240252458A1 · Aug 1, 2024
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