Psilocin mucate
Psilocin formulations of psilocin mucate with improved stability, physical properties and/or handling characteristics, as well as enhanced pharmacologic activity, pharmacokinetic parameters and safety characteristics as compared to psilocin or psilocybin and methods for their use are provided.
1. A psilocin formulation comprising psilocin mucate, said formulation exhibiting:
at least 95% bioavailability of psilocin; and/or
at least twice the bioavailability of an equal amount of psilocin generated by metabolism of psilocybin; and/or
no food effect upon oral administration; and/or
at least a 2-fold decrease in time to maximum concentration (Tmax) as compared to an equivalent formulation of psilocybin.
2. The psilocin formulation of claim 1 exhibiting:
at least 95% bioavailability of psilocin;
at least twice the bioavailability of an equal amount of psilocin generated by metabolism of psilocybin;
no food effect upon oral administration; and
at least a 2-fold decrease in Tmax as compared to an equivalent formulation of psilocybin.
3. The psilocin formulation of claim 1 administered orally to a subject.
4. The psilocin formulation of claim 1 administered daily to a subject.
5. An oral psilocin formulation comprising psilocin mucate which upon oral ingestion delivers concentrations of psilocin equal to intravenous administration of equivalent dose of psilocybin to a subject.
6. The oral psilocin formulation of claim 5 which exhibits decreased patient-to-patient variability as compared to psilocybin treatment.
7. A method for increasing maximum blood concentration (Cmax) of psilocin in a subject compared to equivalent dose of psilocybin administration, said method comprising administering the psilocin formulation of claim 1 to the subject.
8. The method of claim 7 wherein Cmax is at least twice that of an equal amount of psilocin generated by metabolism of psilocybin.
9. The method of claim 7 wherein the subject experiences an anti-anxiolytic effect.
10. The method of claim 7 wherein the subject exhibits no or less hallucinogenic effect as compared to a subject administered an equal amount of psilocin generated by metabolism of psilocybin.
11. The method of claim 7 wherein the psilocin formulation is administered orally to the subject.
12. The method of claim 7 wherein the psilocin formulation is administered daily to the subject.
13. A method for increasing bioavailability of psilocin in a subject as compared to an equal amount of psilocin generated by metabolism of psilocybin, said method comprising administering the psilocin formulation of claim 1 to the subject.
14. The method of claim 13 wherein the subject experiences an anti-anxiolytic effect.
15. The method of claim 13 wherein the anti-anxiolytic effect is sustained.
16. The method of claim 13 wherein the subject exhibits no or less hallucinogenic effect as compared to a subject administered an equal amount of psilocin generated by metabolism of psilocybin.
17. The method of claim 13 wherein the psilocin formulation is administered orally to the subject.
18. The method of claim 13 wherein the psilocin formulation is administered daily to the subject.
19. A method for more rapidly treating a disease or condition in a subject treatable with psilocin or psilocybin as compared to an equivalent amount of psilocybin treatment, said method comprising administering to the subject the psilocin formulation of claim 1 .
20. A method for producing a psilocin salt with stability for 12 or more months, said method comprising mixing psilocin with galactaric acid (mucic acid).