Parallel assembly of chromatography column modules
A parallel assembly of chromatography column modules, the assembly having one common assembly inlet and one common assembly outlet, each column module comprising a bed space filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space of the column module with the assembly inlet and the assembly outlet, wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.
1 . A stacked assembly of chromatography column modules connected in a rigid housing, the assembly having one common assembly inlet and one common assembly outlet, each chromatography column module comprising a bed space filled with chromatography medium and each chromatography column module comprises a central fluid inlet conduit and a central fluid outlet conduit which when the chromatography column module is connected with other chromatography column modules in the rigid housing are adapted to connect the bed space of the chromatography column module with the assembly inlet and the assembly outlet,
wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the stacked assembly,
wherein each chromatography column module comprises multiple pieces including at least one structure that provides mechanical rigidity therein; and
wherein said at least one structure further provides a plurality of peripheral fluid conduits therein, wherein each of the plurality of peripheral fluid conduits are fluidically connected to the central fluid inlet conduit and the central fluid outlet conduit.
2 . The stacked assembly according to claim 1 , wherein said chromatography column modules comprise a fluid distribution module therein.
3 . The stacked assembly according to claim 1 , wherein a compression force is applied to the chromatography column modules to achieve and/or secure fluid tight connections within the fluid conduits of the assembly.
4 . The stacked assembly according to claim 1 , comprising two fluid distribution modules one arranged at each side of the stack of column modules, each fluid distribution module having one distribution module fluid connection representing the assembly inlet or assembly outlet of the stacked assembly and a connection face towards the stack of column modules, the connection face having at least two connection face fluid connections for connecting to the inlet or outlet side of at least two stacked chromatography column modules.
5 . The stacked assembly according to claim 1 , wherein the chromatography column modules are composed of at least two serially connected chromatography column submodules.
6 . The stacked assembly according to claim 1 , wherein at least two of said multiple pieces are connected by welding, screws or adhesive.
7 . The stacked assembly according to claim 1 , wherein the chromatography column modules can be adapted for either parallel or serial connection.
8 . The stacked assembly according to claim 7 , wherein one or more available fluid connections can be shut off, for example, by using insertions during or after moulding or removing of puncture webs.
9 . A chromatography column module adapted to be used in a stacked assembly according to claim 1 .
10 . The chromatography column module according to claim 9 , characterized in that it is disposable.
11 . The chromatography column module according to claim 9 , characterized in that the end pieces and a tube of the chromatography column modules together define the bed space and the end pieces are facing each other when stacking said chromatography column modules and are prepared by molding techniques.
12 . The chromatography column module according to claim 9 , wherein a tube of the chromatography column module is manufactured with integrated fluid conduits.
13 . The chromatography column module according to claim 9 , wherein sealing means are provided to fluid connections of the chromatography column modules.
14 . The chromatography column module according to claim 9 , wherein it is sterilized by gamma radiation.
15 . The chromatography column module according to claim 9 , characterized in that the bed space is prefilled with dry chromatography gel in an amount such that when liquid is added to the bed space the dry gel will swell to a volume occupied in a non confined space that is at least 2% larger than the volume of the confined bed space.
16 . The chromatography column module according to claim 9 , characterized in that it comprises a sensor.
17 . The chromatography column module according to claim 9 , characterized in that it comprises an adjustable flow restrictor.
18 . The chromatography column module according to claim 9 , characterized in that aseptic films are provided to fluid connections between the modules and between the modules and the rigid housing.
19 . The chromatography column module according to claim 9 , wherein the chromatography column module is composed of at least two serially connected chromatography column submodules.
20 . A rigid housing adapted to hold any number of chromatography column modules according to claim 9 in parallel or serial connection mode, wherein said rigid housing comprises two stiff end plates between which the chromatography column modules should be provided and said end plates are adapted to be forced towards each other in order to provide fluid tight connections between fluid connections of the chromatography column modules.