Atraumatically formed tissue compositions, devices and methods of preparation and treatment
A process and system provides for atraumatic preparation of morselized Tissue Particles (TP)s, such as Full Thickness Skin Graft Particles (FTSGPs), cartilage particles and other organ tissue particles, in a liquid medium. The resultant tissue product may be a suspension of Tissue Particles in an aqueous solution and containing highly viable cells and may be rapidly prepared at bedside or in the operating room and conveniently delivered to a patient through a syringe or similar applicator. The morselized Tissues Particles may be used for surgical applications including wound healing, cosmetic surgery, and orthopedic cartilage repairs.
1 . A method of treating a patient comprising:
extracting tissue from a donor site of the patient to be treated or from another donor patient;
forming tissue morsels from said tissue within an aseptic container in a fluid using a system which comprises:
an atraumatic cutting device including a pair of cutting blades supported in juxtaposition within the container, said cutting device forming said morsels by repeatedly atraumatically slicing the tissue between the cutting blades while maintaining viability of the morsels;
an opening in the container for permitting fluid communication with a detachable dispensing device;
a detachable dispensing device for receiving the morsels;
wherein the formed morsels travel through the opening in the container and into the dispensing device; and
applying the morsels to a portion of the patient's body to be treated using the dispensing device.
2 . The method of claim 1 , wherein the tissue is organ tissue selected from the group consisting of a full thickness skin graft and cartilage.
3 . The method of claim 2 wherein the organ tissue is a partial thickness skin graft.
4 . The method of claim 1 , wherein the system further comprises a filter for separating the morsels from the fluid.
5 . The method of claim 1 , wherein the fluid is filtered from the morsels prior to application to the patient.
6 . The method of claim 1 , wherein a predominant amount of the cells tissue remain viable.
7 . The method of claim 1 , wherein the donor site is then closed by sutures, staples, adhesives or a combination thereof during the treatment.
8 . The method of claim 1 , wherein formation of the morsels in the device occurs in about 1 to about 10 minutes.
9 . The method of claim 1 , wherein the donor site is from the abdomen of a patient.
10 . The method of claim 1 , wherein the dispensing device is a syringe.
11 . The method of claim 1 , wherein the fluid comprises saline solution.
12 . The method of claim 1 , wherein the fluid includes a component selected from the group consisting of growth factors, a drug, fibrin glue, autologous platelet rich plasma, and combinations thereof.
13 . The method of claim 1 , wherein the portion of the patient's body to be treated is a wound.
14 . The method of claim 1 , wherein the portion of the patient's body to be treated is an organ.
15 . The method of claim 1 , wherein the portion of the patient's body to be treated is cosmetic.
16 . The method of claim 1 wherein said fluid is a solution selected from a saline-containing solution, an isotonic capable compatible medium capable of buffering pH and combinations thereof.
17 . The method of claim 1 wherein the donor site is selected from the joint of a patient.
18 . The method of claim 1 wherein the portion of the patient's body to be treated is a joint.