IP Library › Granted Patent US 12,661,477
Granted Patent B2
US 12,661,477 · App. 18/421,265 · Granted Jun 23, 2026

Nitric oxide therapies

Inventor: David H. Fine (Cocoa Beach, FL)
Assignee: VERO BIOTECH INC.
A61M16/12A61K31/655A61K33/00A61K47/02A61M5/165A61M15/00A61M15/08A61M15/085A61M16/105A61M35/006A61K9/0043A61K9/0073A61K9/7023A61M2005/006A61M2202/0275A61M2205/75
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Quick Facts
Patent No.
US 12,661,477
App. No.
18/421,265
Granted
Jun 23, 2026
Kind
B2
Abstract

A method for delivering nitric oxide therapy to a subject can include administering a composition including a nitric-oxide releasing agent and silica to the subject and releasing a therapeutic amount of nitric oxide from the composition.

Claims (13)

1 . A nitric-oxide delivery device comprising:

a composition comprising a nitric-oxide-releasing agent and silica, wherein the silica is wetted with an antioxidant, wherein the composition is present in a therapeutic amount,

and wherein the nitric-oxide delivery device delivers the therapeutic amount of nitric oxide to a patient, and wherein the therapeutic amount is greater than 100 ppm,

wherein the silica is present as a silica gel or as a sintered mixture of silica gel and one or more thermoplastic resins.

2 . The nitric-oxide delivery device of claim 1 , wherein the nitric-oxide releasing agent comprises a biopolymer.

3 . The nitric-oxide delivery device of claim 2 , wherein the biopolymer comprises N 2 O 2 -functional groups.

4 . The nitric-oxide delivery device of claim 3 , wherein the nitric-oxide releasing agent is represented by a formula:

wherein X is an organic or inorganic moiety and X′ is an organic or inorganic substituent, a pharmaceutically acceptable metal center, or a pharmaceutically acceptable cation.

5 . The nitric-oxide delivery device of claim 4 , wherein X is (CH 3 ) 2 CHNH, CH 3 CH 2 ) 2 N, H 2 N(CH 2 ) 3 NH 2 + (CH 2 ) 4 N[N(O)NO] − (CH 2 ) 3 NH 2 , 2-(ethylamino)ethylamine, as in the zwitterion CH 3 CH 2 N[N(O)NO] − CH 2 CH 2 NH 3 + , 3-(n-propylamino)propylamine, as in the zwitterion CH 3 CH 2 CH 2 N[N(O)NO] − CH 2 CH 2 CH 2 NH 3 + ), O − , or any derivatives thereof.

6 . The nitric-oxide delivery device of claim 1 , wherein the composition further comprises water.

7 . The nitric-oxide delivery device of claim 1 , wherein the antioxidant comprises at least one of vitamin C or vitamin E.

8 . The nitric-oxide delivery device of claim 1 , wherein the antioxidant comprises antioxidant includes at least one of ascorbic acid, alpha tocopherol, or gamma tocopherol.

9 . The nitric-oxide delivery device of claim 1 , wherein the nitric-oxide delivery device comprises an inhaler, nasal plug, an adhesive strip, ointment or any combination thereof.

Assignments (4)
SECURITY INTEREST Recorded Mar 16, 2026
From: VERO BIOTECH INC.
To: SYMBIOTIC CAPITAL AGENCY LLC, AS COLLATERAL AGENT
Reel/Frame 075117/0935 →
CHANGE OF NAME Recorded Apr 24, 2024
From: VERO BIOTECH LLC
To: VERO BIOTECH INC.
Reel/Frame 067206/0340 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 24, 2024
From: FINE, DAVID H.
To: GENO LLC
Reel/Frame 067206/0485 →
CHANGE OF NAME Recorded Apr 24, 2024
From: GENO LLC
To: VERO BIOTECH LLC
Reel/Frame 067207/0535 →
Continuity (6)
Continuation 17461484 · Aug 30, 2021
Continuation 14948992 · Nov 23, 2015
Continuation 14138061 · Dec 21, 2013
Continuation 12819670 · Jun 21, 2010
Provisional Application 61219200 · Jun 22, 2009
Related Publication 20240342424A1 · Oct 17, 2024
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