IP Library › Granted Patent US 12,305,206
Granted Patent B2
US 12,305,206 · App. 18/435,340 · Granted May 20, 2025

Methods for making L-glufosinate

Inventors: Brian Michael Green (Lutherville, MD); Michelle Lorraine Gradley (Canterbury, GB)
Assignee: BASF SE
C12P13/02A01N25/30A01N57/20C12N1/20C12N9/10C12P9/00C12P13/04C12P41/00C12Y104/03003C12Y206/01019
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Quick Facts
Patent No.
US 12,305,206
App. No.
18/435,340
Granted
May 20, 2025
Kind
B2
Abstract

Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.

Claims (13)

1. A formulation comprising:

L-glufosinate ammonium in an amount from 10-30% by weight of the formulation and D-glufosinate, wherein the formulation has greater than about 90% L-glufosinate compared to the sum of the D-glufosinate and the L-glufosinate present in the formulation;

one or more additional components selected from the group consisting of:

sodium alkyl ether sulfate in an amount from 10-40% by weight of the formulation;

1-methoxy-2-propanol in an amount from 0.5-2% by weight of the formulation;

dipropylene glycol in an amount from 4-18% by weight of the formulation;

alkyl polysaccharide in an amount from 4-20% by weight of the formulation; and

water as the balance of the formulation.

2. The formulation of claim 1 , wherein the L-glufosinate composition comprises L-glufosinate ammonium in an amount of 12.25% by weight of the formulation; and wherein the one or more additional components comprise sodium alkyl ether sulfate in an amount of 31.6% by weight of the formulation; 1-methoxy-2-propanol in an amount of 1% by weight of the formulation; dipropylene glycol in an amount of 8.6% by weight of the formulation; alkyl polysaccharide in an amount of 9.8% by weight of the formulation; and water in an amount of 36.75% by weight of the formulation.

3. The formulation of claim 1 , wherein the L-glufosinate composition comprises L-glufosinate ammonium in an amount of 24.5% by weight of the formulation; and wherein the one or more additional components comprise sodium alkyl ether sulfate in an amount of 31.6% by weight of the formulation; 1-methoxy-2-propanol in an amount of 1% by weight of the formulation; dipropylene glycol in an amount of 8.6% by weight of the formulation; alkyl polysaccharide in an amount of 9.8% by weight of the formulation; and water in an amount of 24.5% by weight of the formulation.

4. The formulation of claim 1 , wherein the L-glufosinate composition comprises L-glufosinate ammonium in an amount of 12.25% by weight of the formulation; and wherein the one or more additional components comprise sodium alkyl ether sulfate in an amount of 15.8% by weight of the formulation; 1-methoxy-2-propanol in an amount of 0.5% by weight of the formulation; dipropylene glycol in an amount of 4.3% by weight of the formulation; alkyl polysaccharide in an amount of 4.9% by weight of the formulation; and water in an amount of 62.25% by weight of the formulation.

5. The formulation of claim 1 , wherein the L-glufosinate composition comprises L-glufosinate ammonium in an amount of 12.25% by weight of the formulation; and wherein the one or more additional components comprise sodium alkyl ether sulfate in an amount of 22.1% by weight of the formulation; 1-methoxy-2-propanol in an amount of 1% by weight of the formulation; alkyl polysaccharide in an amount of 6.2% by weight of the formulation; and water in an amount of 58.45% by weight of the formulation.

6. The formulation of claim 1 , wherein the L-glufosinate composition comprises L-glufosinate ammonium in an amount of 24.5% by weight of the formulation; and wherein the one or more additional components comprise sodium alkyl ether sulfate in an amount of 22.1% by weight of the formulation; 1-methoxy-2-propanol in an amount of 1% by weight of the formulation; alkyl polysaccharide in an amount of 6.2% by weight of the formulation; and water in an amount of 46.2% by weight of the formulation.

Continuity (10)
Continuation 18179136 · Mar 6, 2023
Continuation 17530018 · Nov 18, 2021
Continuation 16997133 · Aug 19, 2020
Continuation 16287290 · Feb 27, 2019
Continuation 15787448 · Oct 18, 2017
Division 15445254 · Feb 28, 2017
Provisional Application 62413240 · Oct 26, 2016
Provisional Application 62336989 · May 16, 2016
Provisional Application 62302421 · Mar 2, 2016
Related Publication 20240309409A1 · Sep 19, 2024
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