POLYMER COATING FOR MEDICAL DEVICES AND METHOD OF MANUFACTURE THEREOF
Disclosed herein is a bio-resistant article comprising a porous metal substrate; a self-assembled monolayer disposed on the substrate; wherein the self-assembled monolayer comprises a coupling agent that has a first end that is reactively bonded to the porous metal substrate and a second end that is reactively bonded to a zwitterionic polymer. Disclosed herein too is a method comprising disposing upon a porous metal substrate a self-assembled monolayer; and bonding the zwitterionic polymer to the self-assembled monolayer.
1 . A bio-resistant article comprising:
a porous metal substrate;
a self-assembled monolayer disposed on the substrate; wherein the self-assembled monolayer comprises a coupling agent that has a first end that is reactively bonded to the porous metal substrate and a second end that is reactively bonded to a zwitterionic polymer,
wherein the bio-resistant article is a biomedical implant or drug delivery device.
2 . The bio-resistant article of claim 1 , wherein the porous metal surface comprises a metal; wherein the metal comprises iron, zinc, magnesium, aluminum, gold, platinum, stainless steel, titanium, tantalum, iridium, molybdenum, niobium, palladium, chromium, or alloys thereof.
3 . The bio-resistant article of claim 1 , wherein the porous metal surface comprises a metal; wherein the metal comprises iron, zinc, magnesium, aluminum, platinum, stainless steel, titanium, tantalum, iridium, molybdenum, niobium, palladium, chromium, or alloys thereof.
4 . The bio-resistant article of claim 1 , wherein the porous metal surface has an average pore diameter of about 10 nanometers to about 100 micrometers.
5 . The bio-resistant article of claim 4 , wherein the porous metal surface has an average pore diameter of about 100 nanometers to about 1 micrometer.
6 . The bio-resistant article of claim 1 , wherein the porous metal surface comprises a metal oxide; wherein the metal oxide comprises tantalum oxide, titanium oxide, iridium oxide, niobium oxide, zirconium oxide, tungsten oxide, rhodium oxide, or a combination thereof.
7 . The bio-resistant article of claim 1 , wherein the first end comprises a first reactive functionality that comprises a silane, a thiol, a carboxyl, an amide, an imide, an ester, a sulfate ester, a phosphate ester, a thiophosphate ester, a borate ester, a urea, an epoxide, a carbamate, a thiocarbamate, a thiosulfate, a sulfonate, a phosphonate, a halogen thiophosphonate, a nitro, a nitroso, a nitrate, a nitrite, or a combination thereof.
8 . The bio-resistant article of claim 1 , wherein the zwitterionic polymer is polymerized from a monomer by a reactive initiator located at the second end of the coupling agent.
9 . The bio-resistant article of claim 1 , wherein the zwitterionic polymer is polyphosphorylcholine, polysulfobetaine, polycarboxybetaine, polytrimethylamine N-oxide, or a combination thereof.
10 . The bio-resistant article of claim 1 , wherein the zwitterionic polymer is polytrimethylamine N-oxide.
11 . The bio-resistant article of claim 10 , wherein the zwitterionic polymer forms a layer that is less than 1000 nanometers thick.
12 . The bio-resistant article of claim 1 , wherein the bio-resistant article is a drug delivery device.
13 . The bio-resistant article of claim 1 , wherein the bio-resistant article is a biomedical implant.
14 . The bio-resistant article of claim 3 , wherein the bio-resistant article is a drug delivery device.
15 . The bio-resistant article of claim 3 , wherein the bio-resistant article is a biomedical implant.
16 . A method for fabricating an article, comprising:
disposing upon a porous metal substrate a self-assembled monolayer; and
bonding a zwitterionic polymer to the self-assembled monolayer,
wherein the article is a biomedical implant or drug delivery device.
17 . The method of claim 16 , further comprising reactively bonding the self-assembled monolayer to the substrate.
18 . The method of claim 17 , further comprising initiating polymerization of the zwitterionic polymer via a reactive initiating functionality disposed on an end of the self-assembled monolayer.
19 . A bio-resistant article comprising:
a porous metal substrate;
a self-assembled monolayer disposed on the substrate; wherein the self-assembled monolayer comprises a coupling agent that has a first end that is reactively bonded to the porous metal substrate and a second end that is reactively bonded to a zwitterionic polymer,
wherein the porous metal surface comprises a metal; wherein the metal comprises iron, zinc, magnesium, aluminum, platinum, stainless steel, titanium, tantalum, iridium, molybdenum, niobium, palladium, chromium, or alloys thereof.
20 . The bio-resistant article of claim 19 , wherein the bio-resistant article is a blood contacted sensor.