IP Library Granted Patent US 12,349,874
Granted Patent B2
US 12,349,874 · App. 18/454,266 · Granted Jul 8, 2025

Saliva collection and testing system

Inventors: Renjith Menon (Campbell, CA); Loc Phan (Santa Clara, CA); Nichole Garcia (Laguna Beach, CA)
Assignee: Smylio Inc.
A61B10/0051A61B5/14507A61B5/14539A61B5/14546A61B5/4875A61B5/682A61B2560/04
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Quick Facts
Patent No.
US 12,349,874
App. No.
18/454,266
Granted
Jul 8, 2025
Kind
B2
Abstract

A system with a saliva sampling device configured to be orally worn by a patient. The saliva sampling device is a polymer retainer or aligner. A saliva analysis engine is used to correlate one or more analytes of one or more saliva samples with one or more health attributes. A health monitoring engine updates a health profile of the patient based on the correlated health attributes.

Claims (29)

1. A saliva sampling device configured to be orally worn by a user, comprising:

one or more polymer shells formed to a shape of teeth so as to fit over the teeth when orally worn;

wherein the saliva sampling device is configured to collect at least one saliva sample over one or more hours or days during incremental wearing periods of the saliva sampling device by the user;

wherein the at least one saliva sample is collected by the saliva sampling device at one or more time periods initiated by user action with the saliva sampling device that enables sampling of saliva; and

wherein the user action comprises removal of a cover on a storage access location on the saliva sampling device.

2. The saliva sampling device of claim 1 , wherein each of the incremental wearing periods is at least one hour.

3. The saliva sampling device of claim 1 , wherein the at least one saliva sample is one of a plurality of saliva samples collected by the saliva sampling device over a plurality of hours or days.

4. The saliva sampling device of claim 1 , wherein the saliva sampling device further comprises at least one biosensor.

5. The saliva sampling device of claim 1 , wherein the saliva sampling device further comprises a plurality of saliva storage portions configured to store the at least one saliva sample over the one or more hours or days, and wherein the plurality of saliva storage portions comprises at least one saliva storage portion that is enabled by application of user force.

6. The saliva sampling device of claim 1 , wherein the saliva sampling device comprises at least one communication device configured to wirelessly connect with a network and/or a network access device, wherein the saliva sampling device wireless transmits data for at least one analyte sourced from the at least one saliva sample, the data indicative or non-indicative of at least one analyte.

7. The saliva sampling device of claim 1 , wherein the user action comprises the removal of a cover on a storage access location on the saliva sampling device by a user, and wherein the storage access location comprises an opening in a portion of the saliva sampling device.

8. The saliva sampling device of claim 1 , wherein the at least one analyte sample comprises one or more analytes for indication of hydration levels or cellular osmotic conditions of the user.

9. The saliva sampling device of claim 1 , wherein the saliva sampling device comprises one selected from the group consisting of: an orthodontic retainer and an orthodontic aligner.

10. The saliva sampling device of claim 9 , wherein the at least one saliva sample is one of a plurality of saliva samples collected by the saliva sampling device over a plurality of hours or days.

11. The saliva sampling device of claim 9 , wherein the saliva sampling device further comprises at least one biosensor.

12. The saliva sampling device of claim 9 , wherein the saliva sampling device further comprises a plurality of saliva storage portions configured to store the at least one saliva sample over the one or more hours or days, and wherein the plurality of saliva storage portions comprises at least one saliva storage portion that is enabled by application of user force.

13. The saliva sampling device of claim 9 , wherein the saliva sampling device comprises at least one communication device configured to wirelessly connect with a network and/or a network access device, wherein the saliva sampling device wireless transmits data for at least one analyte sourced from the at least one saliva sample, the data indicative or non-indicative of at least one analyte.

14. The saliva sampling device of claim 9 , wherein the at least one analyte sample comprises one or more analytes for indication of hydration levels or cellular osmotic conditions of the user.

15. The saliva sampling device of claim 1 , further comprising:

one or more storage access locations; and

one or more covers covering the one or more storage access locations, wherein the one or more covers are configured to be removed to enable sampling of saliva.

16. The saliva sampling device of claim 15 , wherein the one or more storage access locations comprises a plurality of openings; wherein the one or more covers is a plurality of covers covering the plurality of openings, and wherein each of the plurality of covers are configured to be removed so as to enable sampling at different time periods.

17. The saliva sampling device of claim 16 , wherein the plurality of covers comprises a bioabsorbable cover.

18. The saliva sampling device of claim 15 , wherein the one or more storage access locations is a plurality of storage access locations; wherein the one or more covers is a plurality of covers covering the plurality of storage access locations; and wherein each of the plurality of covers is configured to be removed so as to enable sampling at different time periods.

19. The saliva sampling device of claim 1 , further comprising:

a plurality of storage access locations;

a plurality of covers covering the plurality of storage access locations;

wherein each of the plurality of covers is configured to be removed so as to enable sampling of saliva at different time periods.

20. The saliva sampling device of claim 19 , wherein plurality of covers comprises a plurality of bioabsorbable covers configured to erode or absorb at different points during use.

Assignments (2)
SECURITY INTEREST Recorded Aug 30, 2024
From: SMYLIO INC.
To: WESTERN ALLIANCE BANK
Reel/Frame 068456/0676 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 23, 2023
From: MENON, RENJITH; PHAN, LOC; GARCIA, NICHOLE
To: SMYLIO INC.
Reel/Frame 064678/0930 →
Continuity (3)
Continuation 17092262 · Nov 7, 2020
Provisional Application 62932396 · Nov 7, 2019
Related Publication 20230389903A1 · Dec 7, 2023
References Cited (5)
US 9811818B1 · Xing · 2017 [cited by applicant]
US 20160367188A1 · Malik · 2016 [cited by examiner]
US 20180360430A1 · Bailey · 2018 [cited by examiner]
US 20190284631A1 · Leung · 2019 [cited by applicant]
Previously submitted information: U.S. Appl. No. 17/092,262, filed Nov. 7, 2020 is relied upon for an earlier effective filing date under 35 U.S.C. 120. [cited by applicant]