IP Library Granted Patent US 12,350,434
Granted Patent B2
US 12,350,434 · App. 18/455,177 · Granted Jul 8, 2025

Nitrogen dioxide storage device

Inventors: Barry N. Gellman (Melbourne, FL); Eddie Tajudeen (Orlando, FL); Lucas Gamero (Oviedo, FL); Joshua Hopkins (Casselberry, FL); Edward E. A. Bromberg (Orlando, FL); Ryan Denton (Central City, CO); Bryan J. Johnson (Orlando, FL); David Fine (Cocoa Beach, FL)
Assignee: VERO Biotech Inc.
A61M16/12C01B21/24A61M2016/0027A61M2016/003A61M16/107A61M2202/0275A61M2205/12
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Quick Facts
Patent No.
US 12,350,434
App. No.
18/455,177
Granted
Jul 8, 2025
Kind
B2
Abstract

A nitric oxide delivery system can include a cassette which is a single use disposable component used to store liquid N 2 O 4 activate upon operator demand, convert N 2 O 4 to NO 2 via a heating element(s) controlled by a console to deliver NO 2 at a controlled flow rate, direct concentrated NO 2 to a contained pair of conversion cartridges and exhaust NO gas to the console for delivery to the patient.

Claims (17)

1. An apparatus comprising

a liquid module comprising a plurality of safety elements and an ampule comprising liquid N 2 O 4 ; wherein the ampule is secured in a two-position component, wherein the two-position component comprises a first of the plurality of safety elements present at each position, wherein the ampule is shuttled within the two-positioned component between the two positions in linear, rotational, and/or radial motion;

wherein the apparatus forms gaseous NO from the liquid N 2 O 4 for inhalation; and

wherein the plurality of safety elements prevent environmental exposure to the liquid N 2 O 4 .

2. The apparatus of claim 1 , wherein the liquid module further comprises one or more heating devices that are in electrical and thermal communication with the ampule.

3. The apparatus of claim 1 , wherein the first of the plurality of one or more safety elements present at each position comprises a seal.

4. The apparatus of claim 1 , wherein a second of the plurality of safety elements comprises an affixing member that secures the ampule to the two-position component.

5. The apparatus of claim 4 , wherein the affixing member is a shard containment barrier.

6. The apparatus of claim 1 , wherein one of the two positions of the two-positions component is in communication with an inerting chamber.

7. The apparatus of claim 1 , wherein a second of the two positions of the two-positions component is an output side configured to deliver the gaseous NO for inhalation.

8. The apparatus of claim 1 , wherein the inerting chamber comprises a colored material configured to indicate a breakage of the ampule.

9. The apparatus of claim 1 , wherein a third of the plurality of safety elements comprise a leak-valve.

10. The apparatus of claim 1 , wherein a fourth of the plurality of safety elements comprise a seal positioned at an air inflow port of the apparatus and a seal positioned at a NO gas outflow port of the apparatus.

11. The apparatus of claim 1 , wherein a fifth of the plurality of safety elements comprise a purge material.

12. The apparatus of claim 1 , wherein the liquid module is capable of withstanding internal pressure up to 100 psi and a temperature of up to 70° C.

13. The apparatus of claim 1 , further comprising a restrictor.

14. The apparatus of claim 1 , further comprising a cartridge comprising a porous rigid matrix and an antioxidant, wherein the cartridge is configured to form the gaseous NO.

Assignments (6)
RELEASE OF SECURITY INTEREST Recorded Mar 18, 2026
From: HORIZON TECHNOLOGY FINANCE CORPORATION
To: VERO BIOTECH INC.
Reel/Frame 075308/0198 →
SECURITY INTEREST Recorded Mar 16, 2026
From: VERO BIOTECH INC.
To: SYMBIOTIC CAPITAL AGENCY LLC, AS COLLATERAL AGENT
Reel/Frame 075117/0935 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 28, 2023
From: GELLMAN, BARRY N.; GAMERO, LUCAS; HOPKINS, JOSHUA; BROMBERG, EDWARD E.A.; DENTON, RYAN; JOHNSON, BRYAN J.; FINE, DAVID H.
To: GENO LLC
Reel/Frame 065683/0848 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 28, 2023
From: TAJUDEEN, EDDIE
To: VERO BIOTECH LLC
Reel/Frame 065683/0882 →
CHANGE OF NAME Recorded Nov 28, 2023
From: GENO LLC
To: VERO BIOTECH LLC
Reel/Frame 065694/0041 →
CHANGE OF NAME Recorded Nov 28, 2023
From: VERO BIOTECH LLC
To: VERO BIOTECH INC.
Reel/Frame 065694/0050 →
Continuity (5)
Continuation 16988185 · Aug 7, 2020
Continuation 16283724 · Feb 22, 2019
Division 14918511 · Oct 20, 2015
Provisional Application 62066345 · Oct 20, 2014
Related Publication 20240075240A1 · Mar 7, 2024
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