Granted Patent B2

US 12,661,407 · App. 18/462,080 · Granted Jun 23, 2026

Inventors: Dov Tamarkin (Maccabim, IL); Elana Gazal (Rehovot, IL); Yohan Hazot (Rehovot, IL); David Schuz (Gimzu, IL); Irakliy Papiashvili (Ashkelon, IL)

Assignee: Journey Medical Corporation

A61K47/44A61K8/31A61K8/342A61K8/361A61K9/0014A61K9/0048A61K9/12A61K9/122A61K9/124A61K31/137A61K31/192A61K31/4164A61K31/57A61K31/573A61K31/593A61K31/65A61K45/06A61K47/02A61K47/06A61K47/10A61K47/12A61K47/24A61Q17/04A61Q19/00A61Q19/10A61K2800/31A61K2800/33

Abstract

Claims (24)

1 . A method of treating rosacea, comprising administrating a foam composition comprising:

a) a combination of at least one fatty alcohol and at least one wax; or a combination of at least one fatty alcohol, at least one fatty acid, and at least one wax;

b) at least one hydrophobic solvent; and

c) a minocycline at a concentration between about 0.2% and about 20% by weight of the composition;

wherein the composition is free of surfactant;

wherein the composition is essentially waterless;

wherein the ratio of (1) fatty alcohol to wax or (2) fatty alcohol and fatty acid to wax is between about 1:3 and about 3:1; and

wherein the wax comprises a mixture of beeswax and hydrogenated castor oil.

2 . The method of claim 1 , wherein the minocycline is present in a free base form, a hydrate form, a salt form, or a complex form.

3 . The method of claim 1 , wherein the foam composition further comprises a tetracycline, an oxytetracycline, a demeclocycline, a doxycycline, a lymecycline, a meclocycline, a methacycline, a rolitetracycline, a chlorotetracycline, a tigecycline, or a mixture of two or more thereof.

4 . The method of claim 1 , wherein the foam composition further comprises a doxycycline.

5 . The method of claim 1 , wherein the concentration of the minocycline is between about 1% and about 10% by weight of the composition.

6 . The method of claim 1 , wherein the concentration of the minocycline is between about 1% and about 4% by weight of the composition.

7 . The method of claim 1 , wherein the concentration of the minocycline is about 1.5% by weight of the composition.

8 . The method of claim 1 , wherein the at least one fatty alcohol comprises 14 carbon atoms in its backbone.

9 . The method of claim 1 , wherein the fatty alcohol comprises stearyl alcohol, cetostearyl alcohol, behenyl alcohol, and/or myristyl alcohol.

10 . The method of claim 1 , wherein the at least one fatty alcohol is present at a concentration from about 0.1% to about 20% by weight of the composition.

11 . The method of claim 1 , wherein the at least one wax and/or the at least one fatty acid is present at a concentration from about 0.1% to about 20% by weight of the composition.

12 . The method of claim 1 , wherein the hydrophobic solvent comprises soybean oil, coconut oil, cyclomethicone, and/or mineral oil.

13 . The method of claim 1 , wherein the hydrophobic solvent is present at a concentration from about 60% to about 95% by weight of the composition.

14 . The method of claim 1 , wherein the foam composition further comprises a silicon dioxide.

15 . The method of claim 1 , wherein the beeswax and hydrogenated castor oil are at a ratio of about 4:3.

16 . The method of claim 1 , wherein the beeswax and hydrogenated castor oil are at a ratio of about 1:1.

17 . The method of claim 1 , wherein treating rosacea comprises treating inflammatory lesions of rosacea.

Assignments (2)

Continuity (17)

References Cited (400)