COMPOSITIONS AND METHODS FOR THE TREATMENT OF PRESBYOPIA
Provided herein is an ophthalmological composition and methods for the treatment of presbyopia. In some embodiments, the ophthalmological composition comprises aceclidine and brimonidine.
1 . An ophthalmological composition comprising aceclidine and brimonidine.
2 . The ophthalmological composition of claim 1 , wherein when administered to an eye of a subject the ophthalmological composition results in reduced eye redness of the subject compared to an otherwise identical ophthalmological composition comprising aceclidine as the sole active agent.
3 . The ophthalmological composition of claim 1 , wherein the ophthalmological composition comprises a pH from about 4.0 to about 8.0.
4 . The ophthalmological composition of claim 1 , wherein the ophthalmological composition has an initial viscosity of at least 20 centipoises (“cps”) at a shear of 1/s, the initial viscosity being the viscosity of the ophthalmological composition on upon administration to the eye.
5 . The ophthalmological composition of claim 1 , wherein after administration to an eye forms an administered composition having a first viscosity, the first viscosity being the viscosity of the administered ophthalmological composition between eyelid blinks.
6 . The ophthalmological composition of claim 5 , wherein the first viscosity is between 10 cps and 100 cps.
7 . The ophthalmological composition of claim 5 , wherein the administered composition has a second viscosity, the second viscosity being the viscosity of the administered ophthalmological composition during an eyelid blink.
8 . The ophthalmological composition of claim 7 , wherein the second viscosity is 30 cps or less.
9 . The ophthalmological composition of claim 7 , wherein when administered to the eye of a subject an increased residence time of aceclidine on the eye is produced.
10 . The ophthalmological composition of claim 1 , wherein the ophthalmological composition is free of a preservative.
11 . The ophthalmological composition of claim 7 , wherein the ophthalmological composition is free of a preservative.
12 . The ophthalmological composition of claim 1 , wherein the ophthalmological composition is free of benzalkonium ion.
13 . The ophthalmological composition of claim 7 , wherein the ophthalmological composition is free of benzalkonium ion.
14 . A method of treating presbyopia comprising administering to an eye of a subject in need thereof an ophthalmological composition comprising aceclidine and brimonidine.
15 . The method of claim 14 , wherein the ophthalmological composition has an initial viscosity of at least 20 cps at a shear of 1/s, the initial viscosity being the viscosity of the ophthalmological composition on upon administration to the eye.
16 . The method of claim 14 , wherein after administration to an eye forms an administered composition having a first viscosity, the first viscosity being the viscosity of the administered ophthalmological composition between eyelid blinks.
17 . The ophthalmological composition of claim 16 , wherein the first viscosity is between 10 cps and 100 cps.
18 . The method of claim 16 , wherein the administered composition has a second viscosity, the second viscosity being the viscosity of the administered ophthalmological composition during an eyelid blink that is different from the first viscosity.
19 . The ophthalmological composition of claim 18 , wherein the second viscosity is 30 cps or less.
20 . The method of claim 14 , wherein the ophthalmological composition is free of benzalkonium ion.