IP Library Granted Patent US 12,288,620
Granted Patent B2
US 12,288,620 · App. 18/469,522 · Granted Apr 29, 2025

Method and system for insulin management

Inventors: Robert C. Booth (Greer, SC); Harry Hebblewhite (Atlanta, GA)
Assignee: Glytec, LLC
G16H40/67A61B5/14532A61B5/4839A61M5/14A61M5/1723G16H10/40G16H20/17G16H20/60G16H80/00A61B5/4848A61M2005/14208A61M2005/14296A61M2005/1726A61M2205/18A61M2205/3327A61M2205/35A61M2205/3553A61M2205/3584A61M2205/3592A61M2205/50A61M2205/502A61M2205/507A61M2205/52A61M2205/581A61M2230/201
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Quick Facts
Patent No.
US 12,288,620
App. No.
18/469,522
Filed
Sep 18, 2023
Granted
Apr 29, 2025
Kind
B2
Art Unit
3619
USPC
604/504
Abstract

A method of administering insulin includes receiving blood glucose measurements of a patient at a data processing device from a glucometer. Each blood glucose measurement is separated by a time interval and includes a blood glucose time associated with a time of measuring the blood glucose measurement. The method also includes receiving patient information at the data processing device and selecting a subcutaneous insulin treatment for tube-fed patients from a collection of subcutaneous insulin treatments. The selection is based on the blood glucose measurements and the patient information. The subcutaneous insulin treatment program for tube-fed patients determines recommended insulin doses based on the blood glucose times. The method also includes executing, using the data processing device, the selected subcutaneous insulin treatment.

Claims (55)

1. A computer-implemented method for administering a current day's recommended basal dose to a patient, the method executed on data processing hardware that causes the data processing hardware to perform operations comprising:

receiving a glucose measurement of a patient;

obtaining a previous day's recommended basal dose for a patient;

receiving a plurality of glucose target ranges, where each glucose target range is defined by a lower target limit and an upper target limit associated with a set of configurable constants;

determining an adjustment factor for adjusting a current day's recommended basal dose by comparing the received glucose measurement to two or more of the plurality of glucose target ranges;

determining a value of the current day's recommended basal dose to be administered to the patient by multiplying the adjustment factor with the patient's previous day's recommended basal dose;

transmitting the value of the current day's recommended basal dose to a patient display, the patient display configured to display a number of units of insulin corresponding to the value of the current day's recommended basal dose; and

transmitting the value of the current day's recommended basal dose and instructions to an administration device in communication with the data processing hardware, the instructions when received by the administration device causing the administration device to automatically dial in a number of units of insulin corresponding to the current day's recommended basal dose and administer the number of units of insulin to the patient.

2. The computer-implemented method of claim 1 , wherein the operations further comprise;

obtaining patient information comprising a target glucose range for the patient, the target glucose range comprising a range of glucose values between and including a lower limit glucose value and an upper limit glucose value greater than the lower limit glucose value;

determining a value of a correction bolus based on the received glucose measurement by calculating:

CB =( GM−GM Target )/ CF,

wherein CB is the correction bolus, GM is the received glucose measurement, GM Target is a midpoint of the target glucose range for the patient, and CF is a correction factor; and

transmitting the value of the correction bolus and second instructions to the administration device in communication with the data processing hardware, the second instructions when received by the administration device causing the administration device to automatically dial in a second number of units of insulin corresponding to the correction bolus and administer the second number of units of insulin to the patient.

3. The computer-implemented method of claim 2 , wherein the operations further comprise transmitting the correction bolus to the patient display during a time interval that includes a measurement time for the received glucose measurement of the patient, the patient display configured to display a number of units of insulin corresponding to a value of the correction bolus.

4. The computer-implemented method of claim 2 , wherein the correction factor is determined by calculating:

CF=CFR/TDD,

wherein CF is the correction factor, CFR is a constant determined from a statistical correlation, and TDD is a total daily dose of insulin per day.

5. The computer-implemented method of claim 1 , wherein receiving the glucose measurement of the patient comprises receiving the glucose measurement from a glucose meter in communication with the data processing hardware.

6. The computer-implemented method of claim 1 , wherein receiving the glucose measurement of the patient comprises receiving the glucose measurement from a continuous glucose monitoring system in communication with the data processing hardware.

7. The method of claim 1 , wherein the plurality of glucose target ranges of values comprises:

a first glucose target range including glucose values less than a first configurable constant;

a second glucose target range including glucose values greater than or equal to the first configurable constant and less than a second configurable constant;

a third glucose target range including glucose values greater than or equal to the second configurable constant and less than a third configurable constant;

a fourth glucose target range including glucose values greater than or equal to the third configurable constant and less than a fourth configurable constant;

a fifth glucose target range including glucose values greater than or equal to the fourth configurable constant and less than a fifth configurable constant; and

a sixth glucose target range including glucose values greater than or equal to the fifth configurable constant.

8. A system for administering a current day's recommended basal dose to a patient, the system comprising:

a dosing controller including a data processing device and a non-transitory computer-readable medium in communication with the data processing device, the dosing controller configured to perform operations comprising:

receiving a glucose measurement of a patient;

obtaining a previous day's recommended basal dose for a patient;

receiving a plurality of glucose target ranges, where each glucose target range is defined by a lower target limit and an upper target limit associated with a set of configurable constants;

determining an adjustment factor for adjusting a current day's recommended basal dose by comparing the received glucose measurement to two or more of the plurality of glucose target ranges;

determining a value of the current day's recommended basal dose to be administered to the patient by multiplying the adjustment factor with the patient's previous day's recommended basal dose;

transmitting the value of the current day's recommended basal dose to a patient display, the patient display configured to display a number of units of insulin corresponding to the value of the current day's recommended basal dose; and

transmitting the value of the current day's recommended basal dose and instructions to an administration device in communication with the data processing hardware, the instructions when received by the administration device causing the administration device to automatically dial in a number of units of insulin corresponding to the current day's recommended basal dose and administer the number of units of insulin to the patient.

9. The system of claim 8 , wherein the operations further comprise;

obtaining patient information comprising a target glucose range for the patient, the target glucose range comprising a range of glucose values between and including a lower limit glucose value and an upper limit glucose value greater than the lower limit glucose value;

determining a correction bolus based on the glucose measurement by calculating:

CB =( GM−GM Target )/ CF,

wherein CB is the correction bolus, GM is the glucose measurement, GM Target is a midpoint of the target glucose range for the patient, and CF is a correction factor; and

transmitting the value of the correction bolus and second instructions to the administration device in communication with the data processing hardware, the second instructions when received by the administration device causing the administration device to automatically dial in a second number of units of insulin corresponding to the correction bolus and administer the second number of units of insulin to the patient.

10. The system of claim 9 , wherein the operations further comprise transmitting the correction bolus to the patient display during a time interval that includes a measurement time for the received glucose measurement of the patient, the patient display configured to display a number of units of insulin corresponding to a value of the correction bolus.

11. The system of claim 9 , wherein correction factor is determined by calculating:

CF=CFR/TDD,

wherein CF is the correction factor, CFR is a constant determined from a statistical correlation, and TDD is a total daily dose of insulin per day.

12. The system of claim 8 , wherein receiving the glucose measurement of the patient comprises receiving the glucose measurement from a glucose meter in communication with the data processing hardware.

13. The system of claim 8 , wherein receiving the glucose measurement of the patient comprises receiving the glucose measurement from a continuous glucose monitoring system in communication with the data processing hardware.

14. The system of claim 8 , wherein the plurality of glucose target ranges of values comprises:

a first glucose target range including glucose values less than a first configurable constant;

a second glucose target range including glucose values greater than or equal to the first configurable constant and less than a second configurable constant;

a third glucose target range including glucose values greater than or equal to the second configurable constant and less than a third configurable constant;

a fourth glucose target range including glucose values greater than or equal to the third configurable constant and less than a fourth configurable constant;

a fifth glucose target range including glucose values greater than or equal to the fourth configurable constant and less than a fifth configurable constant; and

a sixth glucose target range including glucose values greater than or equal to the fifth configurable constant.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 2, 2024
From: ASEKO, INC.
To: GLYTEC, LLC
Reel/Frame 067320/0764 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 10, 2023
From: BOOTH, ROBERT C.; HEBBLEWHITE, HARRY
To: ASEKO, INC.
Reel/Frame 065527/0975 →
Continuity (8)
Continuation 17813440 · Jul 19, 2022
Continuation 16574056 · Sep 17, 2019
Continuation 15862310 · Jan 4, 2018
Continuation 14524756 · Oct 27, 2014
Continuation 14524756 · Oct 27, 2014
Provisional Application 62009575 · Jun 9, 2014
Provisional Application 61934300 · Jan 31, 2014
Related Publication 20240013913A1 · Jan 11, 2024
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