IP Library Granted Patent US 12,409,436
Granted Patent B2
US 12,409,436 · App. 18/472,316 · Granted Sep 9, 2025

Device and method for producing high-concentration, low-temperature nitric oxide

Inventors: Michael Paris (Lansdale, PA); Kirill Gutsol (Warminster, PA); Howard Nelson (Pennington, NJ); David Meck (Bloomfield, NJ); Lindley Curameng (Fort Lee, NJ); Andre' DiMino (Woodcliff Lake, NJ)
Assignee: Origin Life Sciences, Inc.
B01J19/088A61K33/00A61P9/08C01B21/24C01B21/32A61B18/042A61M13/003A61M2202/0275B01J2219/0809B01J2219/0871
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Quick Facts
Patent No.
US 12,409,436
App. No.
18/472,316
Granted
Sep 9, 2025
Kind
B2
Abstract

A device and method for forming NO-containing gas flow to treat a biological object is disclosed. The device may include an anode, a cathode, an interelectrode area between the cathode and the anode, an NO-containing gas flow outlet channel leading from the interelectrode area to a nozzle for directing and releasing the NO-containing gas flow from the device and a mechanism to adjust a relative position between the anode and the cathode to produce varying concentrations of NO. In addition, the device may include one or more features for interconnecting the various components to ensure proper and consistent assembly of the device.

Claims (38)

1. A method for forming NO-containing gas flow to treat a biological object, the method comprising:

forming an NO-containing gas flow in an interelectrode area of a device, wherein the device comprises:

an anode;

a cathode;

an insulator disposed about the cathode;

a cathode insulator disposed about a portion of the insulator;

the interelectrode area disposed between the cathode and the anode;

an interim electrode disposed about a proximal end of the cathode;

a chamber standoff coupled between the interim electrode and the anode;

wherein the insulator, cathode insulator, and chamber standoff are made from a dielectric material;

directing the NO-containing gas flow from the device via an NO-containing gas flow outlet channel leading from the interelectrode area to a nozzle; and

directing the NO-containing gas flow from the nozzle toward the biological object to treat the biological object.

2. The method of claim 1 , further comprising creating a vortex of fluid flow as the fluid flow passes through the interelectrode area using plurality of holes formed in an outer perimeter of a distal end of the cathode.

3. The method of claim 2 , wherein the plurality of holes comprise a plurality of tangentially oriented holes.

4. The method of claim 2 , wherein the plurality of holes are configured to direct fluid from a central hollow portion of the cathode out of the plurality of holes such that the fluid swirls around the cathode to thereby surround a plasma and its afterglow as it goes out through the interim electrode and the anode to thereby assist in in arc stabilization.

5. The method of claim 2 , further comprising further comprising enabling an electrical arc to occur between the interim electrode and a hafnium tip associated with the cathode, the electrical arc emanating into the interelectrode area.

6. The method of claim 1 , further comprising providing a pathway for a cooling fluid to interact with the cathode using one or more coolant entryways in the insulator.

7. The method of claim 1 , further comprising providing a pathway for air to be forced through the cathode and into the interelectrode area using a central hollow portion of the cathode.

8. The method of claim 1 , further comprising separating the NO-containing gas flow outlet channel from a cooling fluid while directing the NO-containing gas flow to the nozzle using a fluid divider having first and second flat surfaces.

9. A method for forming NO-containing gas flow to treat a biological object, the method comprising:

forming an NO-containing gas flow in an interelectrode area of a device, wherein the device comprises:

an anode,

a cathode, and

an insulator surrounding the cathode, the cathode including a plurality of tangentially arranged holes for creating a vortex of a fluid flow as the fluid exits the cathode;

a cathode insulator disposed about the insulator;

the interelectrode area between the cathode and the anode;

an interim electrode disposed about a proximal end of the cathode;

an interim electrode standoff coupled between the insulator and the interim electrode; and

a chamber standoff coupled between the interim electrode and the anode;

directing the NO-containing gas flow from the device via a flow outlet channel leading from the interelectrode area; and

directing the NO-containing gas flow from the nozzle toward the biological object to treat the biological object.

10. The method of claim 9 , wherein at least one of the insulator, cathode insulator, and chamber standoff are made from a dielectric material.

11. The method of claim 9 , further comprising creating said vortex of fluid flow as the fluid flow passes through the interelectrode area using the plurality of tangentially arranged holes.

12. The method of claim 9 , wherein the plurality of holes are configured to direct a fluid from a central hollow portion of the cathode out of the plurality of holes such that the fluid swirls around the cathode to thereby surrounds the plasma and its afterglow as it goes out through the interim electrode and the anode to thereby assist in in arc stabilization.

13. The method of claim 9 , further comprising enabling an electrical arc to occur between the interim electrode and a hafnium tip associated with the cathode, the electrical arc emanating into the interelectrode area.

14. The method of claim 9 , further comprising providing a pathway for a cooling fluid to interact with the cathode using one or more coolant entryways in the insulator.

15. The method of claim 9 , further comprising providing a pathway for air to be forced through the cathode and into the interelectrode area using a central hollow portion of the cathode.

16. The method of claim 9 , further comprising separating the NO-containing gas flow outlet channel from a cooling fluid while directing the NO-containing gas to the nozzle using a fluid divider having first and second flat surfaces.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 31, 2025
From: PARIS, MICHAEL; GUTSOL, KIRILL; NELSON, HOWARD; CURAMENG, LINDLEY; DIMINO, ANDRE
To: ORIGIN, INC.
Reel/Frame 071892/0015 →
CHANGE OF NAME Recorded Jul 31, 2025
From: ORIGIN, INC.
To: ORIGIN LIFE SCIENCES, INC.
Reel/Frame 072299/0229 →
SECURITY INTEREST Recorded Sep 6, 2024
From: ORIGIN LIFE SCIENCES, INC.
To: DISTRICT 2 CAPITAL FUND LP
Reel/Frame 068515/0595 →
Continuity (4)
Continuation 17106311 · Nov 30, 2020
Continuation 15841228 · Dec 13, 2017
Provisional Application 62434018 · Dec 14, 2016
Related Publication 20240066495A1 · Feb 29, 2024
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