IP Library › Granted Patent US 12,349,966
Granted Patent B2
US 12,349,966 · App. 18/476,028 · Granted Jul 8, 2025

Methods and devices for endovascular ablation of a splanchnic nerve

Inventors: Anisha Bapna (Edison, NJ); Zoar Jacob Engelman (New York, NY); Howard Levin (Teaneck, NJ); Pajhand Iranitalab (San Ramon, CA); Casey Andrew Miller (Campbell, CA); Thomas Ryan McGrath (Santa Clara, CA); Manuel Arzadon Javier, Jr. (Santa Clara, CA)
Assignee: AXON THERAPIES, INC.
A61B18/1492A61B6/12A61B6/4441A61B6/481A61B6/504A61B34/20A61B90/39A61B2018/00404A61B2018/00577A61B2034/2065A61B2090/3966
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Quick Facts
Patent No.
US 12,349,966
App. No.
18/476,028
Filed
Sep 27, 2023
Granted
Jul 8, 2025
Kind
B2
Art Unit
3797
USPC
600/424
Abstract

Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are methods of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.

Claims (11)

1. A method of characterizing a position of a human patient's azygos vein relative to a portion of the patient's spine, comprising:

imaging at least one radiopaque device, positioned in the azygos vein and/or in an intercostal vein, relative to a portion of the spine, using a radiographic imaging device, to thereby characterize the position of the patient's azygos vein relative to a midline of the spine; and

determining if the azygos vein is centered, left-biased or right biased with respect to midline of a vertebra based on one or more images generated by said imaging device; and

subsequent to determining whether the azygos vein is centered, left-biased or right biased with respect to the midline of the vertebra, in the patient whose azygos vein is determined to be left-biased with respect to the midline of the vertebra and not centered or right biased with respect to the midline of the vertebra, positioning a distal end of an energy delivery device in the intercostal vein and positioning a radiopaque marker at the midline of the vertebra.

2. The method of claim 1 , wherein positioning the radiopaque marker at the midline of the vertebra comprises distally advancing the radiopaque marker to the midline of the vertebra.

3. The method of claim 1 , wherein positioning the radiopaque marker at the midline of the vertebra comprises positioning the radiopaque marker within the intercostal vein distal to an ostium of the intercostal vein.

4. The method of claim 1 , wherein the energy delivery device further comprises an ablation element distal to the radiopaque marker, wherein positioning the radiopaque marker at the midline of the vertebra comprises positioning the ablation element in the intercostal vein.

5. The method of claim 4 , wherein positioning the radiopaque marker comprises positioning the ablation element in a T9, T10, or T11 intercostal vein.

6. The method of claim 4 , wherein positioning the radiopaque marker positions the ablation element proximal to a sympathetic trunk.

7. The method of claim 4 , wherein positioning the radiopaque marker positions the ablation element between an ostium of the intercostal vein and a sympathetic trunk.

8. The method of claim 4 , further comprising delivering ablation energy using the ablation element to ablate a greater splanchnic nerve.

Assignments (6)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 1, 2025
From: AXON THERAPIES, INC.
To: AXON (ASSIGNMENT FOR THE BENEFIT OF CREDITORS), LLC
Reel/Frame 071149/0588 →
PATENT ASSIGNMENT AGREEMENT Recorded Nov 13, 2024
From: AXON (ASSIGNMENT FOR THE BENEFIT OF CREDITORS), LLC
To: AXON VASCULAR, INC.
Reel/Frame 069353/0549 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 14, 2024
From: ENGELMAN, ZOAR JACOB; LEVIN, HOWARD
To: CORIDEA, LLC
Reel/Frame 066465/0274 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 7, 2024
From: ENGELMAN, ZOAR JACOB; LEVIN, HOWARD
To: CORIDEA, LLC
Reel/Frame 066411/0929 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 30, 2024
From: BAPNA, ANISHA; IRANITALAB, PAJHAND; MILLER, CASEY ANDREW; MCGRATH, THOMAS RYAN; JAVIER, MANUEL ARZADON, JR.
To: AXON THERAPIES, INC.
Reel/Frame 066301/0638 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 30, 2024
From: CORIDEA, LLC
To: AXON THERAPIES, INC.
Reel/Frame 066301/0807 →
Continuity (5)
Continuation 17451991 · Oct 22, 2021
Continuation PCTUS2020038934 · Jun 22, 2020
Provisional Application 62881251 · Jul 31, 2019
Provisional Application 62864093 · Jun 20, 2019
Related Publication 20240206963A1 · Jun 27, 2024
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