Granted Patent
B2
US 12,527,519 · App. 18/476,935 · Granted Jan 20, 2026
Neurostimulation devices and methods
Inventors:
Steven D. Goedeke (Forest Lake, MN); Steven L. Waldhauser (Savage, MN); Mark A. Christopherson (Shoreview, MN); Mark R. Christianson (Plymouth, MN)
Assignee:
Cardionomix, Inc.
A61B5/4836A61B5/02028A61B5/02158A61B5/0823A61B5/287A61B5/349A61B5/4848A61B5/6858A61B5/6859A61B5/7246A61B6/12A61B6/487A61B18/1492A61M25/10A61N1/056A61N1/0573A61N1/36114A61N1/36139A61N1/3627A61N1/36585A61B2018/00214A61B2018/00267A61B2018/00279A61B2018/00285A61B2018/00351A61B2018/00839A61B2562/0247A61B2562/028A61M2025/0003A61N1/0558A61N2001/058A61N1/36017A61N1/36117A61N1/36135A61N1/36146A61N1/36185
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Abstract
A device includes a handle, an expandable structure including a plurality of splines extending from a proximal hub to a distal hub, a first electrode on a first spline of the plurality of splines, an outer tube extending from the handle to the proximal hub, and a shaft extending through the outer tube from the handle to the distal hub. The expandable structure has a collapsed state and a self-expanded state. The handle is configured to retract the shaft. Retracting the shaft may expand the expandable structure outward of the self-expanded state.
Claims (29)
1 . A method of monitoring effect of neurostimulation on left ventricle contractility, the method comprising:
positioning a neurostimulator in a pulmonary artery; positioning a pressure sensor in a right ventricle;
measuring contractility of the right ventricle using the pressure sensor; applying neurostimulation to the neurostimulator;
determining contractility of the left ventricle based on the measured contractility of the right ventricle; and
monitoring the effect of the neurostimulation on the left ventricle contractility based on the measured contractility of the right ventricle.
2 . The method of claim 1 , wherein measuring the contractility of the right ventricle is before applying the neurostimulation.
3 . The method of claim 1 , wherein measuring the contractility of the right ventricle is during applying the neurostimulation.
4 . The method of claim 1 , wherein measuring the contractility of the right ventricle is after applying the neurostimulation.
5 . The method of claim 1 , further comprising adjusting a parameter of the neurostimulation based on the left ventricle contractility.
6 . The method of claim 5 , wherein adjusting the parameter of the neurostimulation comprises turning the neurostimulation on and off.
7 . The method of claim 1 , wherein measuring the contractility of the right ventricle comprises taking an average or a weighted average of measurements from the pressure sensor.
8 . The method of claim 1 , wherein the pressure sensor comprises a MEMS sensor.
9 . The method of claim 1 , wherein the neurostimulator is on a catheter, wherein the pressure sensor is integrated in the catheter, and wherein the method further comprises using closed loop control to affect the neurostimulation.
10 . The method of claim 9 , wherein using closed loop control comprises at least one of adjusting a parameter of the neurostimulation or turning the neurostimulation on and off.
11 . A method of monitoring effect of neurostimulation on left ventricle contractility, the method comprising:
positioning a catheter m a pulmonary artery, the catheter comping a neurostimulator;
positioning a pressure sensor in a right ventricle;
measuring contractility of the right ventricle using the pressure sensor; applying neurostimulation to the neurostimulator;
measuring contractility of the right ventricle using the pressure sensor; and
determining contractility of the left ventricle based on the measured contractility of the right ventricle.
12 . The method claim 11 , wherein measuring the contractility of the right ventricle is before applying the neurostimulation.
13 . The method claim 11 , wherein measuring the contractility of the right ventricle is during applying the neurostimulation.
14 . The method claim 11 , wherein measuring the contractility of the right ventricle is after applying the neurostimulation.
15 . The method claim 11 , wherein the pressure sensor comprises a MEMS sensor.
16 . The method claim 11 , wherein the pressure sensor is integrated in the catheter.
17 . The method of claim 11 , further comprising using closed loop control to affect the neurostimulation based on the contractility of the left ventricle.
18 . The method of claim 17 , wherein using closed loop control comprises adjusting a parameter of the neurostimulation.
19 . The method of claim 17 , wherein using closed loop control comprises turning the neurostimulation on and off.
20 . The method of claim 11 , further comprising determining an effect of the neurostimulation on the left ventricle contractility.
Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 17, 2025
From: CARDIONOMIC (ASSIGNMENT FOR THE BENEFIT OF CREDITORS), LLC
To: CARDIONOMIX, INC.
Reel/Frame 071437/0606 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 28, 2025
From: CARDIONOMIC, INC.
To: CARDIONOMIC (ASSIGNMENT FOR THE BENEFIT OF CREDITORS), LLC
Reel/Frame 070964/0227 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 6, 2024
From: WALDHAUSER, STEVEN L.; GOEDEKE, STEVEN D.; CHRISTIANSON, MARK R.; CHRISTOPHERSON, MARK A.; SERDAR, DAVID J.; CHRISTIAN, STEVEN C.; EUTENEUER, CHARLES L.
To: CARDIONOMIC, INC.
Reel/Frame 066671/0501 →
Continuity (9)
Continuation
PCTUS2017021214
· Mar 7, 2017
Provisional Application
62464039
· Feb 27, 2017
Provisional Application
62305988
· Mar 9, 2016
Provisional Application
62343302
· May 31, 2016
Related Publication
20240225533A9
· Jul 11, 2024
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