POLYMER PARTICLES
Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.
1 . A polymer particle, comprising a spherical diameter between about 40 μm and about 1,200 μm, and a reaction product of a prepolymer solution including:
at least one monomer including at least one functional group; and
at least one crosslinker including at least two functional groups.
2 . The polymer particle of claim 1 , wherein the at least one crosslinker further includes at least one linkage susceptible to breakage to impart biodegradation to the polymer particle.
3 . The polymer particle of claim 2 , wherein the biodegradation provides less than about 10% of the polymer particle intact after about 5 days.
4 . The polymer particle of claim 1 , wherein the spherical diameter is between about 75 μm and about 1,200 μm.
5 . The polymer particle of claim 2 , wherein the biodegradation is through hydrolysis or enzymatic action.
6 . The polymer particle of claim 1 , wherein the at least one crosslinker is bis-glycidyl amino alcohol,
wherein a, b, c, d, e, and f are each independently 1-20.
7 . The polymer particle of claim 2 , wherein the at least one linkage is an ester, a thioester, a carbonate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, a peptide cleavable by matrix cathepsins, or a combination thereof.
8 . The polymer particle of claim 1 , wherein the at least one crosslinker is bis-glycidyl amino alcohol or bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate.
9 . The polymer particle of claim 2 , including a second crosslinker including a second linkage selected from an ester, a thioester, a carbonate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, or a peptide cleavable by matrix cathepsins.
10 . The polymer particle of claim 1 , wherein the at least one functional group is acrylate, acrylamide, methacrylate, or methacrylamide.
11 . The polymer particle of claim 1 , wherein the at least one monomer includes an ionizable functional group.
12 . The polymer particle of claim 11 , wherein the ionizable functional group is basic or acidic.
13 . The polymer particle of claim 1 , wherein the at least one monomer is dimethylacrylamide and the at least one crosslinker is bis-glycidyl amino alcohol.
14 . The polymer particle of claim 1 , wherein the at least one monomer is acrylamide and the at least one crosslinker is bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate.
15 . The polymer particle of claim 1 , having a circularity greater than about 0.9.
16 . An embolic solution, including a plurality of the polymer particle of claim 1 .
17 . The embolic solution of claim 16 , wherein the embolic solution is sterilized.
18 . The embolic solution of claim 16 , including a radiopaque contrast agent.
19 . The embolic solution of claim 16 , including a dye.
20 . A method, comprising administration of the embolic solution of claim 16 to a location in a subject.
21 . The method of claim 20 , wherein the location in the subject is a location in a vessel in the subject.
22 . A compound, selected from
wherein a, b, c, d, e, and f are each independently 1-20.
23 . A polymer, comprising a reaction product of a prepolymer solution including:
at least one monomer including at least one functional group; and
at least one crosslinker selected from
wherein a, b, c, d, e, and f are each independently 1-20.