Granted Patent
B2
US 12,453,651 · App. 18/488,723 · Granted Oct 28, 2025
Micro-droplet delivery device and methods
Assignee:
Bausch + Lomb Ireland Limited
View Patent ↗
Loading inventors, assignments & file history…
Abstract
Micro-droplet delivery devices and methods are described where the device may comprise a piezoelectric actuator having a piezoelectric chip that is operatively coupled to a drug package under a preloading force. The actuator is configured to generate an acoustic pressure within the drug package to dispense droplets of an agent from an aperture, e.g., to the corneal surface of the eye. The piezoelectric actuator can be coupled or decoupled from the drug package.
Claims (48)
1. A fluid delivery device, the device comprising:
a drug package having:
(a) a reservoir configured to contain a fluid;
(b) a cavity to accommodate a volume of the fluid from the reservoir;
(c) an aperture through which the fluid in the cavity can be ejected; and
(d) a pathway between the reservoir and the cavity to direct the fluid from the reservoir into the cavity, the pathway having a cross-sectional area smaller than that of the cavity; and
an actuator designed to oscillate against the cavity in order to generate fluid pressure within the cavity and from which the fluid is ejected through the aperture.
2. The device of claim 1 , wherein the aperture has a diameter of 80-120 microns.
3. The device of claim 1 , wherein the aperture is tapered.
4. The device of claim 1 , wherein the actuator is configured to have a displacement of 1-5 microns.
5. The device of claim 1 , wherein the pathway further comprises a restriction between the cavity and the reservoir to restrict propagation of the pressure from the cavity to the reservoir.
6. The device of claim 5 , wherein the restriction reduces the cross-sectional area of the pathway by 50-90%.
7. The device of claim 1 , wherein the drug package further comprises:
a venting port to permit air to enter the reservoir as the fluid is dispensed, thereby preventing a vacuum.
8. The device of claim 1 , wherein the drug package further comprises:
a membrane that, when acted upon, generates the pressure within the fluid accommodated by the cavity; and
wherein the actuator oscillates against the membrane to displace the membrane which then generates the pressure within the fluid accommodated by the cavity.
9. An apparatus for emitting a fluid, the apparatus comprising:
a drug package having:
(a) a reservoir configured to contain the fluid;
(b) a cavity to accommodate a volume of the fluid from the reservoir;
(c) an aperture through which the fluid in the cavity can be ejected; and
(d) a pathway between the reservoir and the cavity to direct the fluid from the reservoir into the cavity; and
an actuator designed to oscillate against the cavity in order to generate fluid pressure within the cavity, the presence of which ejects the fluid through the aperture while allowing a cross-sectional area of the pathway to remain smaller than a cross-sectional area of the cavity.
10. The apparatus of claim 9 , wherein the aperture has a diameter of 80-120 microns.
11. The apparatus of claim 9 , wherein the aperture is tapered.
12. The apparatus of claim 9 , wherein the actuator is configured to have a displacement of 1-5 microns.
13. The apparatus of claim 9 , wherein the pathway further comprises a restriction between the cavity and the reservoir to restrict propagation of the pressure from the cavity to the reservoir.
14. The apparatus of claim 13 , wherein the restriction reduces the cross-sectional area of the pathway by 50-90%.
15. The apparatus of claim 9 , wherein the drug package further comprises:
a venting port to permit air to enter the reservoir as the fluid is dispensed, thereby preventing a vacuum.
16. The apparatus of claim 9 , wherein the drug package further comprises:
a membrane that, when acted upon, generates the pressure within the fluid accommodated by the cavity; and
wherein the actuator oscillates against the membrane to displace the membrane which then generates the pressure within the fluid accommodated by the cavity.
17. A fluid delivery device, the device comprising:
a drug package having:
(a) a reservoir configured to contain a fluid;
(b) a cavity to accommodate a volume of the fluid from the reservoir;
(c) an aperture through which the fluid in the cavity can be ejected; and
(d) a pathway between the reservoir and the cavity to direct the fluid from the reservoir into the cavity, the pathway having a cross-sectional area smaller than that of the cavity, the pathway comprising a restriction between the cavity and the reservoir to restrict propagation of the pressure from the cavity to the reservoir, the restriction reducing the cross-sectional area of the pathway by 50-90%; and
an actuator designed to oscillate against the cavity in order to generate fluid pressure within the cavity and from which the fluid is ejected through the aperture.
18. An apparatus for emitting a fluid, the apparatus comprising:
a drug package having:
(a) a reservoir configured to contain the fluid;
(b) a cavity to accommodate a volume of the fluid from the reservoir;
(c) an aperture through which the fluid in the cavity can be ejected; and
(d) a pathway between the reservoir and the cavity to direct the fluid from the reservoir into the cavity, wherein the pathway further comprises a restriction between the cavity and the reservoir to restrict propagation of the pressure from the cavity to the reservoir, wherein the restriction reduces the cross-sectional area of the pathway by 50-90%; and
an actuator designed to oscillate against the cavity in order to generate fluid pressure within the cavity, the presence of which ejects the fluid through the aperture while allowing a cross-sectional area of the pathway to remain smaller than a cross-sectional area of the cavity.
Assignments (7)
ASSIGNMENT OF SECURITY INTEREST IN PATENTS PREVIOUSLY RECORDED AT REEL/FRAME (068716/0551)
Recorded Aug 14, 2025
From: CITIBANK, N.A., AS RESIGNING AGENT
To: JPMORGAN CHASE BANK, N.A., AS SUCCESSOR AGENT
Reel/Frame 072469/0073 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 7, 2025
From: KEDALION THERAPEUTICS, INC.
To: NOVARTIS AG
Reel/Frame 071963/0473 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 7, 2025
From: IVRI, YEHUDA
To: KEDALION THERAPEUTICS, INC.
Reel/Frame 071963/0341 →
PATENT SECURITY AGREEMENT
Recorded Jul 1, 2025
From: BAUSCH & LOMB INCORPORATED; ALDEN OPTICAL LABORATORIES, INC.; BAUSCH + LOMB IRELAND LIMITED
To: CITIBANK, N.A., AS NOTES COLLATERAL AGENT
Reel/Frame 071773/0871 →
INTELLECTUAL PROPERTY SECURITY AGREEMENT
Recorded Aug 21, 2024
From: BAUSCH + LOMB IRELAND LIMITED
To: CITIBANK, N.A., AS NOTES COLLATERAL AGENT
Reel/Frame 068730/0664 →
INTELLECTUAL PROPERTY SECURITY AGREEMENT
Recorded Aug 20, 2024
From: BAUSCH + LOMB IRELAND LIMITED
To: CITIBANK, N.A
Reel/Frame 068716/0551 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 9, 2023
From: NOVARTIS AG
To: BAUSCH + LOMB IRELAND LIMITED
Reel/Frame 065531/0583 →
Continuity (4)
Provisional Application
62125073
· Jan 12, 2015
References Cited (358)
US 3640274A
· Costello
· 1972
[cited by applicant]
US 3779245A
· Windsor
· 1973
[cited by applicant]
US 3812854A
· Michaels et al.
· 1974
[cited by applicant]
US 3861386A
· Harris et al.
· 1975
[cited by applicant]
US 3934585A
· Maurice
· 1976
[cited by applicant]
US 3970250A
· Drews
· 1976
[cited by applicant]
US 3976072A
· Walker
· 1976
[cited by applicant]
US 4159803A
· Cameto et al.
· 1979
[cited by applicant]
US 4300546A
· Kruber
· 1981
[cited by applicant]
US 4334531A
· Reichl et al.
· 1982
[cited by applicant]
US 4338576A
· Takahashi et al.
· 1982
[cited by applicant]
US 4344744A
· Schuster et al.
· 1982
[cited by applicant]
US 4352459A
· Berger et al.
· 1982
[cited by applicant]
US 4465234A
· Maehara et al.
· 1984
[cited by applicant]
US 4632311A
· Nakane et al.
· 1986
[cited by applicant]
US 4655393A
· Berger
· 1987
[cited by applicant]
US 4793339A
· Matsumoto et al.
· 1988
[cited by applicant]
US 4850534A
· Takahashi et al.
· 1989
[cited by applicant]
US 4882150A
· Kaufman
· 1989
[cited by applicant]
US 4952581A
· Bito et al.
· 1990
[cited by applicant]
US 4961345A
· Tsuruoka et al.
· 1990
[cited by applicant]
US 4976259A
· Higson et al.
· 1990
[cited by applicant]
US 4981625A
· Rhim et al.
· 1991
[cited by applicant]
US 5025957A
· Ranalletta et al.
· 1991
[cited by applicant]
US 5171306A
· Vo
· 1992
[cited by applicant]
US 5232363A
· Meller
· 1993
[cited by applicant]
US 5368582A
· Bertera
· 1994
[cited by applicant]
US 5370317A
· Weston
· 1994
[cited by applicant]
US 5487378A
· Robertson et al.
· 1996
[cited by applicant]
US 5549249A
· Foster et al.
· 1996
[cited by applicant]
US 5624057A
· Lifshey
· 1997
[cited by applicant]
US 5627611A
· Scheiner
· 1997
[cited by applicant]
US 5630793A
· Rowe
· 1997
[cited by applicant]
US 5657926A
· Toda
· 1997
[cited by applicant]
US 5692651A
· Fuchs
· 1997
[cited by applicant]
US 5811443A
· DeSantis, Jr. et al.
· 1998
[cited by applicant]
US 5828394A
· Khuri-Yakub et al.
· 1998
[cited by applicant]
US 5938117A
· Ivri
· 1999
[cited by applicant]
US 5958342A
· Gamble et al.
· 1999
[cited by applicant]
US 5960224A
· Sanada et al.
· 1999
[cited by applicant]
US 6024717A
· Ball et al.
· 2000
[cited by applicant]
US 6062212A
· Davison et al.
· 2000
[cited by applicant]
US 6065623A
· Hierzer et al.
· 2000
[cited by applicant]
US 6095376A
· Hennemann et al.
· 2000
[cited by applicant]
US 6196218B1
· Voges
· 2001
[cited by applicant]
US 6232129B1
· Wiktor
· 2001
[cited by applicant]
US 6273092B1
· Nolan
· 2001
[cited by applicant]
US 6302101B1
· Py
· 2001
[cited by applicant]
US 6467476B1
· Ivri et al.
· 2002
[cited by applicant]
US RE38077E
· Cohen et al.
· 2003
[cited by applicant]
US 6543442B2
· Gonda et al.
· 2003
[cited by applicant]
US 6629646B1
· Ivri
· 2003
[cited by applicant]
US 6730066B1
· Bennwik et al.
· 2004
[cited by applicant]
US 6758837B2
· Péclat et al.
· 2004
[cited by applicant]
US 6869275B2
· Dante et al.
· 2005
[cited by applicant]
US 7066398B2
· Borland et al.
· 2006
[cited by applicant]
US 7105357B1
· Kalkum et al.
· 2006
[cited by applicant]
US 7201732B2
· Anderson et al.
· 2007
[cited by applicant]
US 7314938B2
· Shen et al.
· 2008
[cited by applicant]
US 7571722B2
· Wuttke et al.
· 2009
[cited by applicant]
US 7745460B2
· Shen et al.
· 2010
[cited by applicant]
US 7790743B2
· Shen et al.
· 2010
[cited by applicant]
US 7874467B2
· Pardes et al.
· 2011
[cited by applicant]
US 7883031B2
· Collins, Jr. et al.
· 2011
[cited by applicant]
US 7928122B2
· Shen et al.
· 2011
[cited by applicant]
US 8012136B2
· Collins, Jr. et al.
· 2011
[cited by applicant]
US 8048047B2
· Domash
· 2011
[cited by applicant]
US 8056766B2
· Grevin
· 2011
[cited by applicant]
US 8128606B2
· Anderson et al.
· 2012
[cited by applicant]
US 8133210B2
· Al-Abdulla et al.
· 2012
[cited by applicant]
US 8144399B2
· Steenblik et al.
· 2012
[cited by applicant]
US 8168655B2
· Gadek et al.
· 2012
[cited by applicant]
US 8273307B2
· Eickhoff et al.
· 2012
[cited by applicant]
US 8367701B2
· Burnier et al.
· 2013
[cited by applicant]
US 8398001B2
· Borland et al.
· 2013
[cited by applicant]
US 8435544B2
· Mitra et al.
· 2013
[cited by applicant]
US 8544462B2
· Papania et al.
· 2013
[cited by applicant]
US 8545463B2
· Collins, Jr. et al.
· 2013
[cited by applicant]
US 8592450B2
· Gadek et al.
· 2013
[cited by applicant]
US 8629111B2
· Acheampong et al.
· 2014
[cited by applicant]
US 8633162B2
· Acheampong et al.
· 2014
[cited by applicant]
US 8642556B2
· Acheampong et al.
· 2014
[cited by applicant]
US 8648048B2
· Acheampong et al.
· 2014
[cited by applicant]
US 8684980B2
· Hunter et al.
· 2014
[cited by applicant]
US 8685930B2
· Acheampong et al.
· 2014
[cited by applicant]
US 8722728B2
· Wong et al.
· 2014
[cited by applicant]
US 8733935B2
· Ballou, Jr. et al.
· 2014
[cited by applicant]
US 8863998B2
· Painchaud et al.
· 2014
[cited by applicant]
US 8927574B2
· Burnier
· 2015
[cited by applicant]
US 8927921B1
· Nelms et al.
· 2015
[cited by applicant]
US 8936021B2
· Collins, Jr.
· 2015
[cited by applicant]
US 9039666B2
· Voss et al.
· 2015
[cited by applicant]
US 9068566B2
· Ivri
· 2015
[cited by applicant]
US 9085553B2
· Zeller et al.
· 2015
[cited by applicant]
US 9087145B2
· Ballou, Jr. et al.
· 2015
[cited by applicant]
US 9186690B2
· Scanlon et al.
· 2015
[cited by applicant]
US 9216174B2
· Shen et al.
· 2015
[cited by applicant]
US 9238532B2
· Decock et al.
· 2016
[cited by applicant]
US 9248191B2
· Acheampong et al.
· 2016
[cited by applicant]
US 9353088B2
· Burnier
· 2016
[cited by applicant]
US 9447077B2
· Burnier et al.
· 2016
[cited by applicant]
US 9597230B2
· Haffner et al.
· 2017
[cited by applicant]
US 9676525B2
· Greiner-Perth et al.
· 2017
[cited by applicant]
US 9700686B2
· Gavini et al.
· 2017
[cited by applicant]
US 9801757B2
· Voss et al.
· 2017
[cited by applicant]
US 9808825B2
· Aguilar et al.
· 2017
[cited by applicant]
US 9867933B2
· Pardes et al.
· 2018
[cited by applicant]
US 9890141B2
· Burnier
· 2018
[cited by applicant]
US 20010035184A1
· Schuler et al.
· 2001
[cited by applicant]
US 20010036424A1
· Takahashi et al.
· 2001
[cited by applicant]
US 20010036449A1
· Garst
· 2001
[cited by applicant]
US 20020078947A1
· Gumaste
· 2002
[cited by applicant]
US 20020124843A1
· Skiba et al.
· 2002
[cited by applicant]
US 20020158196A1
· Berggren et al.
· 2002
[cited by applicant]
US 20020161344A1
· Peclat et al.
· 2002
[cited by applicant]
US 20020185125A1
· Klimowicz et al.
· 2002
[cited by applicant]
US 20020190079A1
· Hamamoto
· 2002
[cited by applicant]
US 20030052573A1
· Wischnewskiy
· 2003
[cited by applicant]
US 20030065294A1
· Pickup et al.
· 2003
[cited by applicant]
US 20030071071A1
· Garcia et al.
· 2003
[cited by applicant]
US 20030140921A1
· Smith et al.
· 2003
[cited by applicant]
US 20040039355A1
· Gonzalez et al.
· 2004
[cited by applicant]
US 20040050861A1
· Lisec et al.
· 2004
[cited by applicant]
US 20040138630A1
· Al-Abdulla et al.
· 2004
[cited by applicant]
US 20040163645A1
· Connelly et al.
· 2004
[cited by applicant]
US 20040173642A1
· Clifford et al.
· 2004
[cited by applicant]
US 20040204674A1
· Anderson et al.
· 2004
[cited by applicant]
US 20040215157A1
· Peclat et al.
· 2004
[cited by applicant]
US 20040256487A1
· Collins, Jr. et al.
· 2004
[cited by applicant]
US 20040263567A1
· Hess et al.
· 2004
[cited by applicant]
US 20050001981A1
· Anderson et al.
· 2005
[cited by applicant]
US 20050006417A1
· Nicol et al.
· 2005
[cited by applicant]
US 20050107832A1
· Bernabei
· 2005
[cited by applicant]
US 20050172962A1
· Gumaste et al.
· 2005
[cited by applicant]
US 20050207917A1
· Koerner et al.
· 2005
[cited by applicant]
US 20050240162A1
· Chen et al.
· 2005
[cited by applicant]
US 20050261641A1
· Warchol et al.
· 2005
[cited by applicant]
US 20060065677A1
· Py et al.
· 2006
[cited by applicant]
US 20060069358A1
· Gerondale
· 2006
[cited by applicant]
US 20060147313A1
· Zengerle et al.
· 2006
[cited by applicant]
US 20060210604A1
· Dadey et al.
· 2006
[cited by applicant]
US 20070051362A1
· Sullivan et al.
· 2007
[cited by applicant]
US 20070088267A1
· Shekalim
· 2007
[cited by applicant]
US 20070088268A1
· Edwards
· 2007
[cited by applicant]
US 20070102455A1
· Stark et al.
· 2007
[cited by applicant]
US 20070119969A1
· Collins, Jr. et al.
· 2007
[cited by applicant]
US 20070195151A1
· Anderson et al.
· 2007
[cited by applicant]
US 20070268340A1
· Dacquay et al.
· 2007
[cited by applicant]
US 20070295332A1
· Ziegler et al.
· 2007
[cited by applicant]
US 20080039807A1
· Pine
· 2008
[cited by applicant]
US 20080202514A1
· Kriksunov et al.
· 2008
[cited by applicant]
US 20080214940A1
· Benaron et al.
· 2008
[cited by applicant]
US 20080233053A1
· Gross et al.
· 2008
[cited by applicant]
US 20080247264A1
· Gabl et al.
· 2008
[cited by applicant]
US 20080257911A1
· Choi et al.
· 2008
[cited by applicant]
US 20090060793A1
· Eickhoff et al.
· 2009
[cited by applicant]
US 20090114742A1
· Collins, Jr.
· 2009
[cited by applicant]
US 20090134235A1
· Ivri
· 2009
[cited by applicant]
US 20090182291A1
· Eilat
· 2009
[cited by applicant]
US 20090192443A1
· Collins, Jr.
· 2009
[cited by applicant]
US 20090196778A1
· Kitahara
· 2009
[cited by examiner]
US 20090212127A1
· Reynolds et al.
· 2009
[cited by applicant]
US 20090212133A1
· Collins, Jr.
· 2009
[cited by applicant]
US 20090223513A1
· Papania et al.
· 2009
[cited by applicant]
US 20100001090A1
· Neergaard et al.
· 2010
[cited by applicant]
US 20100005903A1
· Beavis
· 2010
[cited by applicant]
US 20100013352A1
· Pletner et al.
· 2010
[cited by applicant]
US 20100044460A1
· Sauzade
· 2010
[cited by applicant]
US 20100072301A1
· Cater
· 2010
[cited by applicant]
US 20100072302A1
· Cater
· 2010
[cited by applicant]
US 20100076388A1
· Cater
· 2010
[cited by applicant]
US 20100147899A1
· Nardi
· 2010
[cited by applicant]
US 20100186738A1
· Kobayashi et al.
· 2010
[cited by applicant]
US 20100222752A1
· Collins, Jr. et al.
· 2010
[cited by applicant]
US 20100236545A1
· Kern
· 2010
[cited by applicant]
US 20100295420A1
· Wierach
· 2010
[cited by applicant]
US 20100326431A1
· Yu
· 2010
[cited by applicant]
US 20110074247A1
· Hohlfeld et al.
· 2011
[cited by applicant]
US 20110102735A1
· Gupta et al.
· 2011
[cited by applicant]
US 20110106025A1
· Hall et al.
· 2011
[cited by applicant]
US 20110146670A1
· Gallem et al.
· 2011
[cited by applicant]
US 20110284579A1
· Pardes et al.
· 2011
[cited by applicant]
US 20110293452A1
· Kim et al.
· 2011
[cited by applicant]
US 20110305425A1
· Fabrykowski et al.
· 2011
[cited by applicant]
US 20120017898A1
· Moller
· 2012
[cited by applicant]
US 20120062840A1
· Ballou, Jr. et al.
· 2012
[cited by applicant]
US 20120070467A1
· Ballou, Jr. et al.
· 2012
[cited by applicant]
US 20120143152A1
· Hunter et al.
· 2012
[cited by applicant]
US 20120179122A1
· Eilat et al.
· 2012
[cited by applicant]
US 20120197219A1
· Scanlon et al.
· 2012
[cited by applicant]
US 20120304929A1
· Ivri
· 2012
[cited by applicant]
US 20130002095A1
· Van der Linden
· 2013
[cited by applicant]
US 20130017283A1
· Zemel et al.
· 2013
[cited by applicant]
US 20130025038A1
· Frey et al.
· 2013
[cited by applicant]
US 20130053042A1
· Tanikawa et al.
· 2013
[cited by applicant]
US 20130053823A1
· Fiering
· 2013
[cited by examiner]
US 20130079733A1
· Burt et al.
· 2013
[cited by applicant]
US 20130118619A1
· Loth et al.
· 2013
[cited by applicant]
US 20130140225A1
· Decock et al.
· 2013
[cited by applicant]
US 20130150812A1
· Hunter et al.
· 2013
[cited by applicant]
US 20130152796A1
· Pawl
· 2013
[cited by applicant]
US 20130153677A1
· Leen et al.
· 2013
[cited by applicant]
US 20130164436A1
· Yagi et al.
· 2013
[cited by applicant]
US 20130172830A1
· Hunter et al.
· 2013
[cited by applicant]
US 20130206857A1
· Ivri
· 2013
[cited by applicant]
US 20130299607A1
· Wilkerson et al.
· 2013
[cited by applicant]
US 20130345672A1
· Ferreri et al.
· 2013
[cited by applicant]
US 20140088524A1
· Marx
· 2014
[cited by applicant]
US 20140113946A1
· Abad
· 2014
[cited by applicant]
US 20140157956A1
· Date et al.
· 2014
[cited by applicant]
US 20140171490A1
· Gross et al.
· 2014
[cited by applicant]
US 20140187969A1
· Hunter et al.
· 2014
[cited by applicant]
US 20140214024A1
· Eichler
· 2014
[cited by applicant]
US 20140224267A1
· Levitz et al.
· 2014
[cited by applicant]
US 20140242022A1
· Vehige et al.
· 2014
[cited by applicant]
US 20140249491A1
· Ballou, Jr. et al.
· 2014
[cited by applicant]
US 20140257172A1
· Yalamanchili
· 2014
[cited by applicant]
US 20140274910A1
· Cumberlidge et al.
· 2014
[cited by applicant]
US 20140276054A1
· Hossack et al.
· 2014
[cited by applicant]
US 20140285121A1
· Balogh et al.
· 2014
[cited by applicant]
US 20140323931A1
· Avni
· 2014
[cited by applicant]
US 20140336596A1
· Wochele
· 2014
[cited by applicant]
US 20140336618A1
· Wilkerson et al.
· 2014
[cited by applicant]
US 20150018781A1
· Rinderknect et al.
· 2015
[cited by applicant]
US 20150035180A1
· Shen et al.
· 2015
[cited by applicant]
US 20150036219A1
· Shen et al.
· 2015
[cited by applicant]
US 20150040891A1
· Avni
· 2015
[cited by applicant]
US 20150086397A1
· Ma
· 2015
[cited by applicant]
US 20150097050A1
· Ciervo
· 2015
[cited by applicant]
US 20150139973A1
· Steinfeld et al.
· 2015
[cited by applicant]
US 20150144128A1
· Hijlkema et al.
· 2015
[cited by applicant]
US 20150209174A1
· Abreu
· 2015
[cited by applicant]
US 20150209178A1
· Blakey et al.
· 2015
[cited by applicant]
US 20150238689A1
· Shimizu
· 2015
[cited by applicant]
US 20150256730A1
· Shen et al.
· 2015
[cited by applicant]
US 20150276994A1
· Shen et al.
· 2015
[cited by applicant]
US 20150308421A1
· Vogt
· 2015
[cited by applicant]
US 20150328151A1
· Ballou, Jr. et al.
· 2015
[cited by applicant]
US 20150352297A1
· Stedman et al.
· 2015
[cited by applicant]
US 20160107180A1
· Decock et al.
· 2016
[cited by applicant]
US 20160120833A1
· Wan et al.
· 2016
[cited by applicant]
US 20160129467A1
· Ciardella et al.
· 2016
[cited by applicant]
US 20160199225A1
· Ivri
· 2016
[cited by applicant]
US 20160199230A1
· Doshi et al.
· 2016
[cited by applicant]
US 20160213866A1
· Tan
· 2016
[cited by applicant]
US 20160263314A1
· Pardes et al.
· 2016
[cited by applicant]
US 20160296367A1
· Ivri
· 2016
[cited by applicant]
US 20160354559A1
· Gavini et al.
· 2016
[cited by applicant]
US 20170028626A1
· Delrot et al.
· 2017
[cited by applicant]
US 20170136484A1
· Wilkerson et al.
· 2017
[cited by applicant]
US 20170138357A1
· Kondo et al.
· 2017
[cited by applicant]
US 20170151088A1
· Ballou, Jr. et al.
· 2017
[cited by applicant]
US 20170156927A1
· Richter et al.
· 2017
[cited by applicant]
US 20170182510A1
· Wilkerson et al.
· 2017
[cited by applicant]
US 20170187969A1
· Kitamori et al.
· 2017
[cited by applicant]
US 20170274159A1
· Gavini et al.
· 2017
[cited by applicant]
US 20170344714A1
· Ballou, Jr. et al.
· 2017
[cited by applicant]
US 20180085251A1
· Hunter et al.
· 2018
[cited by applicant]
US 20180108275A1
· Newberry et al.
· 2018
[cited by applicant]
US 20180116871A1
· Hunter et al.
· 2018
[cited by applicant]
US 20180207030A1
· Ivri et al.
· 2018
[cited by applicant]
US 20180229247A1
· Laidler
· 2018
[cited by applicant]
US 20180236466A1
· Laidler
· 2018
[cited by applicant]
US 20180297053A1
· Buckland et al.
· 2018
[cited by applicant]
US 20190053945A1
· Hunter et al.
· 2019
[cited by applicant]
US 20190074086A1
· Ballou, Jr. et al.
· 2019
[cited by applicant]
US 20190099071A1
· Ehrmann
· 2019
[cited by applicant]
US 20190314195A1
· Ivri et al.
· 2019
[cited by applicant]
US 20190314196A1
· Ivri et al.
· 2019
[cited by applicant]
US 20190314197A1
· Ivri et al.
· 2019
[cited by applicant]
US 20190314198A1
· Ivri et al.
· 2019
[cited by applicant]
US 20200022416A1
· Alarcon
· 2020
[cited by applicant]
US 20200197218A1
· Newell et al.
· 2020
[cited by applicant]
US 20200197220A1
· Ivri
· 2020
[cited by applicant]
US 20200246182A1
· Ivri
· 2020
[cited by applicant]
US 20200281768A1
· Quintana et al.
· 2020
[cited by applicant]
US 20200315842A1
· Palanker et al.
· 2020
[cited by applicant]
US 20200330267A1
· Li et al.
· 2020
[cited by applicant]
US 20210128350A1
· Ivri et al.
· 2021
[cited by applicant]
US 20210137732A1
· Quintana et al.
· 2021
[cited by applicant]
US 20210220169A1
· Ivri
· 2021
[cited by applicant]
US 20210322209A1
· Ivri
· 2021
[cited by applicant]
US 20210322210A1
· Ivri
· 2021
[cited by applicant]
US 20220039998A1
· Ivri
· 2022
[cited by applicant]
US 20220125631A1
· Ianchulev et al.
· 2022
[cited by applicant]
US 20220160542A1
· Palanker et al.
· 2022
[cited by applicant]
US 20220192874A1
· Ivri
· 2022
[cited by applicant]
CN 103118642A
· 2013
[cited by applicant]
CN 104146816A
· 2014
[cited by applicant]
CN 104582647A
· 2015
[cited by applicant]
CN 204813955U
· 2015
[cited by applicant]
CN 105351426A
· 2016
[cited by applicant]
CN 107530509A
· 2018
[cited by applicant]
EP 0622035A1
· 1994
[cited by applicant]
EP 0622035B1
· 1999
[cited by applicant]
EP 1493410A2
· 2005
[cited by applicant]
JP H08251948A
· 1996
[cited by applicant]
JP 3055480U
· 1999
[cited by applicant]
JP 2007531577A
· 2007
[cited by applicant]
JP 2010071283A
· 2010
[cited by applicant]
JP 2013535250A
· 2013
[cited by applicant]
JP 2018515153A
· 2018
[cited by applicant]
KR 101258025B1
· 2013
[cited by applicant]
KR 1020130054352A
· 2013
[cited by applicant]
WO 1994020875A2
· 1994
[cited by applicant]
WO 1996000050A1
· 1996
[cited by applicant]
WO 2000005482A1
· 2000
[cited by applicant]
WO 2001046134A1
· 2001
[cited by applicant]
WO 2002072169A2
· 2002
[cited by applicant]
WO 2006006963A2
· 2006
[cited by applicant]
WO 2010078428A1
· 2010
[cited by applicant]
WO 2012009706A1
· 2012
[cited by applicant]
WO 2013076682A1
· 2013
[cited by applicant]
WO 2013090459A1
· 2013
[cited by applicant]
WO 2013090468A1
· 2013
[cited by applicant]
WO 2013155201A2
· 2013
[cited by applicant]
WO 2013158967A2
· 2013
[cited by applicant]
WO 2016115050A1
· 2016
[cited by applicant]
WO 2016164830A1
· 2016
[cited by applicant]
WO 2018136618A2
· 2018
[cited by applicant]
WO 2018227190A1
· 2018
[cited by applicant]
WO 2019113483A1
· 2019
[cited by applicant]
WO 2020010116A1
· 2020
[cited by applicant]
Abidi et al., “Lifilegrast: A Novel Drug for Treatment of Dry Eye Disease”, Journal of Pharmacology and Pharmacotherapy, 2016, vol. 7, pp. 194-198.
[cited by applicant]
Ali et al., “Glaucoma and Dry Eye”, Ophthalmology, 2009, vol. 116, p. 1232.
[cited by applicant]
Birkhoff et al., “New Devices for Dispensing Ophthalmic Treatments May Be the Key to Managing the Life Cycles of Established Products”, 2010, Drug Delivery Technology, vol. 10, pp. 16-21.
[cited by applicant]
Brenton, “CRUK/10/30: TRICON8—Sample collection of ovarian cancer tissues and blood for translational research from patients participating in the CR-UK/MRC ICON8 trial”, 2015, online abstract.
[cited by applicant]
Choi et al., “Generation of Controllable Monodispersed Sprays Using Impulse Jet and Charging Techniques”, Review of Scientific Instruments, 1990, vol. 61, pp. 1689-1693.
[cited by applicant]
Denion et al., “A 5-Minute Interval between Two Dilating Eye Drops Increases Their Effect”, Jul. 19, 2017, Optometry and Vision Science, vol. 94, pp. 838-844.
[cited by applicant]
Electronic Tutorials, “Linear Solenoid Actuator”, 2016 [online]; [Retrieved on Oct. 17, 2022], Retrieved from the Internet [URL: https://www.electronics-tutorials.ws/io/io_6.html].
[cited by applicant]
Elert, Glenn, “Spherical mirrors”, The Physics Hypertextbook, 2021 [online]; [Retrieved on Oct. 17, 2022], Retrieved from the Internet [URL: https://physics.info/mirrors/].
[cited by applicant]
Gannon, Megan, “The Best Length for Eyelashes, According to Science”, Feb. 24, 2015 [online]; [Retrieved on Oct. 17, 2022], Retrieved from the Internet [URL: https://www.livescience.com/49934-optimal-length-for-eyelashe…
[cited by applicant]
Ianchulev et al., “Pharmacodynamic profile of mydriatic agents delivered by ocular piezo-ejection microdosing compared with conventional eyedropper”, 2016, Ther. Deliv., vol. 7, pp. 751-760.
[cited by applicant]
Jow et al., “Design and Optimization of Printed Spiral Coils for Efficient Transcutaneous Inductive Power Transmission”, IEEE Transactions on Biomedical Circuits and Systems, 2007, vol. 1, pp. 193-202.
[cited by applicant]
Kent, Christopher, “Getting Meds onto the Eye, 21st Century Style”, Mar. 15, 2013 [online]; [Retrieved on Aug. 27, 2019], Retrieved from the Internet [URL: https://www.reviewofophthalmology.com/article/getting-meds-onto…
[cited by applicant]
Kompella et al., “ISOPT Clinical Hot Topic Panel Discussion on Ocular Drug Delivery”, 2019, J. Ocul. Pharmacol. Ther., vol. 35, pp. 457-465.
[cited by applicant]
Lallemand et al., “Cyclosporine a Delivery to the Eye: A Comprehensive Review of Academic and Industrial Efforts”, European Journal of Pharmaceutics and Biopharmaceutics, 2017, vol. 117, pp. 14-28.
[cited by applicant]
Lindblad et al., “Production of Uniform-Sized Liquid Droplets”, Journal of Scientific Instruments, 1965, vol. 42, pp. 635-638.
[cited by applicant]
Lux et al., “A Comparative Bioavailability Study of Three Conventional Eye Drops Versus a Single Lyophilisate”, Br. J. Ophthalmol., 2003, vol. 87, pp. 436-440.
[cited by applicant]
Macmillan Online Dictionary, “Stream,” n.d. [online]; [Retrieved on Dec. 13, 2018]; Retrieved from the Internet [URL: https://macmillandictionary.com/dictionary/american/stream_ 1#stream_9].
[cited by applicant]
Marx et al., “Opthalmic Squeeze Dispenser: Eliminating the Need for Additives in Multidose Preservative-Free Eyecare Formulations”, 2017, Drug Development & Delivery, vol. 17, pp. 40-44.
[cited by applicant]
Merriam-Webster, “Clamp,” 2019 [online]; [Retrieved on Oct. 25, 2022], Retrieved from the Internet [URL: https://www.merriam-webster.com/dictionary/clamp].
[cited by applicant]
Merriam-Webster, “Collimate,” 2020 [online]; [Retrieved on Oct. 17, 2022], Retrieved from the Internet [URL: https://www.merriam-webster.com/dictionary/collimated].
[cited by applicant]
Merriam-Webster, “Stream,” n.d. [online]; [Retrieved on Dec. 13, 2018], Retrieved from the Internet [URL: https://www.merriam-webster.com/dictionary/stream].
[cited by applicant]
Murube et al., “Classification of Artificial Tears, I: Composition and Properties”, Advanced Experimental Medical Biology, 1998, vol. 438, pp. 693-704.
[cited by applicant]
Murube et al., “Classification of Artificial Tears, II: Additives and Commercial Formulas”, Advanced Experimental Medical Biology, 1998, vol. 438, pp. 705-715.
[cited by applicant]
Oxford Online Dictionary, “Stream,” n.d. [online]; [Retrieved on Dec. 13, 2018]; Retrieved from the Internet [URL: https://en.oxforddictionaries.com/definition/us/stream].
[cited by applicant]
Pronin et al., “Teaching an Old Drug New Tricks: Agonism, Antagonism, and Biased Signaling of Pilocarpine through M3 Muscarinic Acetylcholine Receptor”, 2017, Mol. Pharmacol., vol. 92, pp. 601-612.
[cited by applicant]
Vocabulary.com, “Stream,” n.d. [online]; [Retrieved on Dec. 13, 2018]; Retrieved from the Internet [URL: https://www.dictionary.com/stream].
[cited by applicant]
International Search Report and Written Opinion dated Feb. 25, 2016 in corresponding International Patent Application No. PCT/US2016/012903 (8 pages).
[cited by applicant]