IP Library › Granted Patent US 12,226,185
Granted Patent B2
US 12,226,185 · App. 18/489,637 · Granted Feb 18, 2025

Intravascular photoacoustic imaging

Inventors: Gijs Van Soest (Moordrecht, NL); Verya Daeichin (Rotterdam, NL); Antonius Franciscus Wilhelmus Van Der Steen (Rotterdam, NL)
Assignee: Erasmus University Medical Center Rotterdam
A61B5/0035A61B5/0044A61B5/0086A61B5/0095A61B5/02007A61B5/4869A61B5/6852A61B8/0891A61B8/12A61B8/4416A61B8/4477A61B8/4483B06B1/0688A61B5/7225A61B8/483G01S15/8956
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Quick Facts
Patent No.
US 12,226,185
App. No.
18/489,637
Granted
Feb 18, 2025
Kind
B2
Abstract

A catheter-based imaging apparatus comprises a catheter having a proximal end and a distal end. An optical emitter is configured to emit optical excitation signals from a distal portion of the catheter. One or more ultrasound transducers are configured for: (a) transmission of acoustic excitation signals from the distal portion of the catheter; and (b) detection of ultrasound response signals from an object of interest at or near to the distal portion of the catheter at frequencies which include a lower receive frequency at least as low as 10 MHz and a higher receive frequency at least as high as 35 MHz. The one or more ultrasound transducers are thereby configured to detect response signals comprising photoacoustic response signals from the object of interest at the lower receive frequency and high resolution imaging signals from the object of interest at the higher receive frequency.

Claims (31)

1. A catheter-based imaging apparatus comprising:

a catheter having a proximal end and a distal end;

an optical emitter configured to emit optical excitation signals from a distal portion of the catheter;

a first transducer and a second transducer, wherein:

the first transducer has a peak detection sensitivity in a lower frequency range of a first frequency to a second frequency;

the second transducer has a peak detection sensitivity in a higher frequency range of a third frequency to a fourth frequency, the third frequency being no less than the second frequency, and

the catheter-based imaging apparatus is configured for:

(a) transmission of acoustic excitation signals from the distal portion of the catheter with the second transducer;

(b) detection of a photoacoustic response signal with the first transducer, the photoacoustic response signals being from an object of interest at or near to the distal portion of the catheter and excited by the optical excitation signals and

(c) detection of imaging signals with the second transducer, the imaging signals comprising reflections of the acoustic excitation signals from the object of interest wherein the first transducer is configured to be operable at a frequency range which encompasses a lower receive frequency at least as low as 10 MHz and the second transducer is configured to be operable at a frequency range that encompasses a higher receive frequency at least as high as 35 MHz.

2. The catheter-based imaging apparatus of claim 1 , wherein the first transducer comprises a piezoelectric polymer transducer or a piezoelectric composite transducer and the second transducer comprises a piezoelectric ceramic transducer or a piezoelectric composite transducer.

3. The catheter-based imaging apparatus of claim 1 , wherein the first transducer and the second transducer are laterally adjacent to each other.

4. The catheter-based imaging apparatus of claim 3 , wherein the first transducer is located distal to the second transducer.

5. The catheter-based imaging apparatus of claim 3 , wherein the first transducer is located proximal to the second transducer.

6. The catheter-based imaging apparatus of claim 3 , further comprising charge readout circuit, wherein

the first transducer comprises a PVDF transducer, the PVDF transducer and the charge readout circuit being disposed on a common substrate, and

the second transducer comprises a piezoelectric ceramic transducer or a piezoelectric composite transducer.

7. The catheter-based imaging apparatus of claim 1 , wherein the first transducer and the second transducer are in a side-by-side configuration.

8. The catheter-based imaging apparatus of claim 1 , wherein the first transducer and the second transducer are in a back-to-back configuration.

9. The catheter-based imaging apparatus of claim 7 , further comprising charge readout circuit, wherein

the first transducer comprises a PVDF transducer, the PVDF transducer and the charge readout circuit being disposed on a common substrate, and

the second transducer comprises a piezoelectric ceramic transducer or a piezoelectric composite transducer.

10. The catheter-based imaging apparatus of claim 8 , further comprising charge readout circuit, wherein

the first transducer comprises a PVDF transducer, the PVDF transducer and the charge readout circuit being disposed on a common substrate, and

the second transducer comprises a piezoelectric ceramic transducer or a piezoelectric composite transducer.

11. The catheter-based imaging apparatus of claim 4 , further comprising charge readout circuit, wherein

the first transducer comprises a PVDF transducer, the PVDF transducer and the charge readout circuit being disposed on a common substrate, and

the second transducer comprises a piezoelectric ceramic transducer or a piezoelectric composite transducer.

12. The catheter-based imaging apparatus of claim 5 , further comprising charge readout circuit, wherein

the first transducer comprises a PVDF transducer, the PVDF transducer and the charge readout circuit being disposed on a common substrate, and

the second transducer comprises a piezoelectric ceramic transducer or a piezoelectric composite transducer.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 19, 2026
From: STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN
To: ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM
Reel/Frame 074697/0848 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 18, 2023
From: VAN SOEST, GIJS; DAEICHIN, VERYA; VAN DER STEEN, ANTONIUS FRANCISCUS WILHELMUS
To: ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM; STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN
Reel/Frame 065272/0255 →
Priority Claims (1)
GB 1502101 · Feb 9, 2015 · national
Continuity (2)
Continuation 15549552
Related Publication 20240065551A1 · Feb 29, 2024
References Cited (62)
US 4917097A · Proudian et al. · 1990 [cited by applicant]
US 6013032A · Savord · 2000 [cited by applicant]
US 11793405B2 · Van Soest · 2023 [cited by examiner]
US 20080203556A1 · Huang · 2008 [cited by applicant]
US 20100179434A1 · Thornton · 2010 [cited by applicant]
US 20110021924A1 · Sethuraman et al. · 2011 [cited by applicant]
US 20110088477A1 · Someda et al. · 2011 [cited by applicant]
US 20110275890A1 · Wang et al. · 2011 [cited by applicant]
US 20110301458A1 · Li et al. · 2011 [cited by applicant]
US 20120197113A1 · Courtney et al. · 2012 [cited by applicant]
US 20120271170A1 · Emelianov et al. · 2012 [cited by applicant]
US 20130301380A1 · Oraevsky et al. · 2013 [cited by applicant]
US 20130338498A1 · Emelianov et al. · 2013 [cited by applicant]
US 20140018660A1 · Wada · 2014 [cited by examiner]
US 20140112107A1 · Guo et al. · 2014 [cited by applicant]
US 20140180078A1 · Nair · 2014 [cited by applicant]
US 20140187925A1 · Corl · 2014 [cited by applicant]
US 20140236017A1 · Degertekin et al. · 2014 [cited by applicant]
US 20140251017A1 · Kandori · 2014 [cited by applicant]
US 20140276069A1 · Amble et al. · 2014 [cited by applicant]
US 20140378811A1 · Nanaumi · 2014 [cited by applicant]
US 20150057534A1 · Tsujita · 2015 [cited by applicant]
US 20160310083A1 · Wang et al. · 2016 [cited by applicant]
CN 102743191A · 2012 [cited by applicant]
CN 103385758A · 2013 [cited by applicant]
JP H02502078A · 1990 [cited by applicant]
JP 2004057524A · 2004 [cited by applicant]
JP 2013106822A · 2013 [cited by applicant]
WO 2006061829A1 · 2006 [cited by applicant]
WO 2008057573A2 · 2008 [cited by applicant]
WO 2016128359A1 · 2016 [cited by applicant]
Bao-Yu et al., Design and fabrication of an integrated intravascular ultrasound/photoacoustic scan head. Proceedings Spie. 2010;7564. 11 pages. [cited by applicant]
Bao-Yu et al., Integrated intravascular ultrasound and photoacoustic imaging scan head. Optics Letters, Optical Society of America. 2010;35(17). 3 pages. [cited by applicant]
Buja et al., Role of inflammation in coronary plaque disruption. Circulation. 1994;89(1):503-505. [cited by applicant]
Chao et al., A single-cable PVDF Transducer Readout IC for Intravascular Photoacoustic Imaging. 2015 IEEE International Ultrasonics Symposium (IUS). 2015:1-4. [cited by applicant]
Choudhury et al., Molecular, Cellular and Functional Imaging of Atherothrombosis. Nat. Rev. Dur. Discov. 2004;3(11):913-25. [cited by applicant]
Daeichin et al. A Broadband Polyvinylidene Difluoride-Based Hydrophone with Integrated Readout Circuit for Intravascular Photoacoustic Imaging. Ultrasound in Medicine and Biology. 2016;42(5): 1239-43. [cited by applicant]
Diebold et al., Photoacoustic “Signatures” of Particulate Matter: Optical Production of Acoustic Monopole Radiation. Science 250 (4977) 1990. 101-104. [cited by applicant]
Gertsch et al., Toward characterizing the size of microscopic optical absorbers using optoacoustic emission spectroscopy. Proceedings of Spie. 2010. 11 pages. [cited by applicant]
Hysi et al., Photoacoustic radio-frequency spectroscopy (PA-RFS): A technique for monitoring absorber size and concentration. Proc. of SPIE vol. 8581. 2013. 6 pages. [cited by applicant]
International Preliminary Report on Patentability for International Application No. PCT/EP2016/052639 dated Aug. 24, 2017. [cited by applicant]
International Search Report and Written Opinion for International Application No. PCT/EP2016/052639 dated Apr. 29, 2016. [cited by applicant]
Jansen et al., Intravascular photoacoustic imaging of human coronary atherosclerosis. Opt. Lett. 36(5):597-599. 2011. [cited by applicant]
Jansen et al., Intravascular Photoacoustic Imaging: A New Tool for Vulnerable Plaque Identification. U1trasound in Medicine & Biology 40 (6), 1037-1048, 2014. [cited by applicant]
Jansen et al., Lipid detection in atherosclerotic human coronaries by spectroscopic intravascular photoacoustic imaging. Optics Express 21 (18), 21472-21484, 2013. [cited by applicant]
Jansen et al., Spectroscopic intravascular photoacoustic imaging of lipids in atherosclerosis. Journal of Biomedical Optics, S P I E International Society for Optical Engineering. 2014;19(2). 10 pages. [cited by applicant]
Japanese communication for Japanese Application No. 2017-540900 dated Oct. 8, 2019. [cited by applicant]
Karpiouk, A., et al., “Feasibility of in vivo intravascular photoacoustic imaging using integrated ultrasound and photoacoustic imaging catheter” Journal of Biomedical Optics. vol. 17(9), 2012. p. 1-6 (Year: 2012). [cited by applicant]
Kumon et al., Frequency-domain analysis of photoacoustic imaging data from prostate adenocarcinoma tumors in a murine model, Ultrasound Med. Biol. 37 (5), 834-839, 2011. [cited by applicant]
Libby et al., The vascular biology of atherosclerosis and imaging targets. Vascular Biology of Atherosclerosis. J. Nucl. Med. 1 (51), 15, 2010. 6 pages. [cited by applicant]
Libby, Inflammation in atherosclerosis. Nature Publishing Group. 2002;420:868-74. [cited by applicant]
Lloyd-Jones et al., Heart Disease and Stroke Statistics 2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 119 (3), e21-el81, 2009. [cited by applicant]
Ma et al., A Preliminary Engineering Design of Intravascular Dual-Frequency Transducers for Contrast-Enhanced Acoustic Angiography and Molecular Imaging, IEEE Trans. Ultrason. Ferroelectr. Freq. Control 61 (5), 870-880,… [cited by applicant]
Ma, T., et al.‘“Multi-Frequency Intravascular Ultrasound (IVUS) Imaging”’ IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control. vol. 62(1), 2015. p. 97-107 (Year: 2015). [cited by applicant]
Naghavi et al., From Vulnerable Plaque to Vulnerable Patient: A Call for New Definitions and Risk Assessment Strategies: Part II. Circulation 108 (14), 1664-1672, 2003. [cited by applicant]
Puri et al., Exploring coronary atherosclerosis with intravascular imaging. Int. J. Cardiol. 2013;168(2):670-79. [cited by applicant]
Sheu, Y., et al ,“Image Reconstruction in Intravascular Photoacoustic Imaging” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. vol. 58(10), 2011. p. 2067-2077 (Year: 2011). [cited by applicant]
Shriram et al., Intravascular Photoacoustic Imaging Using an IVUS Imaging Catheter. IEEE Transactions on Ultrasonics. Ferroelectrics and frequency control. 2007;53(5):978-86. [cited by applicant]
Treeby et al., k-Wave: MATLAB toolbox for the simulation and reconstruction of photo acoustic wave fields. Journal of Biomedical Optics. 2010;15(2): 1-12. [cited by applicant]
Wang et al., Intravascular photoacoustic imaging of lipid in atherosclerotic plaques in the presence of luminal blood. Opt. Lett. 37 (7), 1244-1246, 2012. [cited by applicant]
Wang et al., Label-Free Bond-Selective Imaging by Listening to Vibrationally Excited Molecules. Phys. Rev. Lett. 106 (23), 10, 2011. 8 pages. [cited by applicant]
Wang et al., Spectroscopic Imaging of Deep Tissue through Photoacoustic Detection of Molecular Vibration. J. Phys. Chem. Lett. 4 (13), 2177-2185, 2013. [cited by applicant]