Methods of treating gastrointestinal stromal tumors
The present disclosure relates to methods of treating gastrointestinal stromal tumors to a subject in need thereof, comprising administering to the subject a therapeutically effective amount of ripretinib or a pharmaceutically acceptable salt thereof.
1. A method of treating gastrointestinal stromal tumors in a patient suffering from Grade 2 arthralgia while being administered 150 mg ripretinib daily, comprising a) withholding administration of ripretinib until the patient has less than or equal to Grade 1 arthralgia or baseline; b) if the patient recovers from the arthralgia within 7 days of withholding administration, then administering to the patient 150 mg daily ripretinib or c) if the patient has not recovered, then administering to the patient 100 mg daily ripretinib for at least 28 days.