NON-HORMONAL STEROID MODULATORS OF NF-KAPPA BETA FOR TREATMENT OF DISEASE
The present invention relates to compounds and methods which may be useful as treatments of diseases.
1 - 9 . (canceled)
10 . A method of treating a disease selected from diffuse intrinsic pontine glioma, epicondylitis, juvenile rheumatoid arthritis, and sickle cell disease, comprising the administration to a patient in need thereof of a therapeutically effective amount of a compound of structural formula
11 . The method of claim 10 , wherein the disease is diffuse intrinsic pontine glioma.
12 . The method of claim 10 , wherein the disease is juvenile rheumatoid arthritis.
13 . The method of claim 10 , wherein the disease is sickle cell disease.
14 . The method of claim 13 , wherein the sickle cell disease is sickle cell anemia.
15 . The method of claim 10 , wherein the administration has a duration of at least about six weeks.
16 . The method of claim 15 , wherein the administration has a duration of at least about fourteen weeks.
17 . The method of claim 10 , wherein the compound is administered orally.
18 . The method of claim 10 , wherein the therapeutically effective amount is greater than or equal to 2 mg/kg/day.
19 . The method of claim 18 , wherein the therapeutically effective amount is between 15 mg/kg/day and 30 mg/kg/day.