IP Library Granted Patent US 12,496,038
Granted Patent B2
US 12,496,038 · App. 18/524,838 · Granted Dec 16, 2025

Image-based diagnostic systems

Inventors: Ross Upton (Oxford, GB); Paul Leeson (Oxford, GB)
Assignee: OXFORD UNIVERSITY INNOVATION LTD.
A61B8/0883A61B8/5223G06T7/0012A61B5/0044G06T2207/10132G06T2207/30048G16H30/40
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Quick Facts
Patent No.
US 12,496,038
App. No.
18/524,838
Granted
Dec 16, 2025
Kind
B2
Abstract

A system for diagnosing a heart condition comprises an imaging system ( 102 ) arranged to acquire two images of the heart at respective points in the cardiac cycle, and locating means, which may be manually operated or automatic, for locating a series of pairs of points on the images. Each pair of points indicates the respective positions of a single part of the heart in the two images. The system further comprises a processor ( 108 ) arranged to calculate from the positions of said pairs of points a value of at least one parameter of the deformation of the heart. It may further be arranged to compare the value of the at least one parameter with reference data to generate a diagnostic output.

Claims (27)

1 . A method for diagnosing a heart condition comprising:

analyzing, by a processor, a set of images, wherein each of the images has a diagnostic outcome associated with it;

calculating, by the processor and based at least in part on the set of images, a one or more values of at least one parameter for each of the images using at least one of a principal transformation or a shear transformation;

analyzing, by the processor, the one or more values and the diagnostic outcomes to determine a relationship or correlation between the one or more values and the diagnostic outcomes;

using machine learning to develop a decision tree for generating the diagnostic outcomes from the values of the parameters, wherein the decision tree comprises a plurality of decision points and each decision point defines a reference or threshold value of at least one of the parameters; and

outputting a diagnosis of a heart condition based on the decision tree,

wherein each of the images is obtained under stress echocardiography conditions.

2 . The method according to claim 1 , further comprising:

storing images as respective data sets;

processing the respective data sets to determine locations of pairs of points of a heart; and

recording said locations of said pairs of points.

3 . The method according to claim 1 , wherein the decision tree is a C4.5 or a J48 pruned decision tree.

4 . The method according to claim 1 , wherein the decision tree comprises determining the value of at least one parameter of the heart for each of the images, wherein each of the images is obtained under stress echocardiography conditions.

5 . A system comprising:

a display; and

a processing unit configured to:

receive a set of images, wherein each of the images has an associated diagnostic outcome;

determine, based at least in part on the set of images, one or more values of at least one parameter for each of the images using at least one of a principal transformation or a shear transformation;

determine a relationship between the one or more values and the diagnostic outcomes;

generate, using machine learning, a decision tree for identifying a diagnosis of a heart condition from the values of the parameters, wherein the decision tree comprises a plurality of decision points and each decision point defines a reference or threshold value of at least one of the parameters; and

output, on the display, the diagnosis of the heart condition.

6 . The system of claim 5 , wherein the processing unit is further configured to:

store images as respective data sets;

process the respective data sets to determine locations of pairs of points of a heart; and

record said locations of said pairs of points.

7 . The system of claim 5 , wherein the decision tree is a C4.5 or a J48 pruned decision tree.

8 . The system of claim 5 , wherein each of the images is obtained under stress echocardiography conditions.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 30, 2023
From: UPTON, ROSS; LEESON, PAUL
To: OXFORD UNIVERSITY INNOVATION LTD.
Reel/Frame 065722/0680 →
Priority Claims (1)
GB 1610269 · Jun 13, 2016 · national
Continuity (3)
Continuation 17179252 · Feb 18, 2021
Continuation 16309432
Related Publication 20240156431A1 · May 16, 2024
References Cited (80)
US 6728394B1 · Chen et al. · 2004 [cited by applicant]
US 8077944B2 · Schummers · 2011 [cited by applicant]
US 8170314B2 · Nozaki · 2012 [cited by applicant]
US 10765407B2 · Yamagata et al. · 2020 [cited by applicant]
US 10776998B1 · Wang et al. · 2020 [cited by applicant]
US 11679230B2 · Tran et al. · 2023 [cited by applicant]
US 11707637B2 · Marquet et al. · 2023 [cited by applicant]
US 20020072671A1 · Chenal · 2002 [cited by applicant]
US 20030187362A1 · Murphy · 2003 [cited by applicant]
US 20040153128A1 · Suresh · 2004 [cited by applicant]
US 20040267125A1 · Skyba · 2004 [cited by applicant]
US 20050020903A1 · Krishnan · 2005 [cited by examiner]
US 20050059876A1 · Krishnan · 2005 [cited by examiner]
US 20050074153A1 · Pedrizzetti · 2005 [cited by applicant]
US 20060074315A1 · Liang et al. · 2006 [cited by applicant]
US 20070014452A1 · Suresh et al. · 2007 [cited by applicant]
US 20070299479A1 · Saksena · 2007 [cited by applicant]
US 20080077032A1 · Holmes · 2008 [cited by applicant]
US 20080260230A1 · Gotardo et al. · 2008 [cited by applicant]
US 20080262814A1 · Zheng et al. · 2008 [cited by applicant]
US 20080294048A1 · Salgo · 2008 [cited by applicant]
US 20080317316A1 · Ohuchi et al. · 2008 [cited by applicant]
US 20090308745A1 · McLeod · 2009 [cited by applicant]
US 20100074475A1 · Chouno · 2010 [cited by applicant]
US 20100208957A1 · Chen et al. · 2010 [cited by applicant]
US 20110035195A1 · Subbiah et al. · 2011 [cited by applicant]
US 20110056876A1 · Ide et al. · 2011 [cited by applicant]
US 20110243401A1 · Zabair et al. · 2011 [cited by applicant]
US 20110313291A1 · Chono · 2011 [cited by applicant]
US 20120027276A1 · Chono · 2012 [cited by applicant]
US 20120089016A1 · Mizuno · 2012 [cited by applicant]
US 20130345563A1 · Stuebe et al. · 2013 [cited by applicant]
US 20140064588A1 · Su · 2014 [cited by applicant]
US 20140334708A1 · Sakata et al. · 2014 [cited by applicant]
US 20150045662A1 · Kim et al. · 2015 [cited by applicant]
US 20150313510A1 · Razavi et al. · 2015 [cited by applicant]
US 20170065230A1 · Sinha · 2017 [cited by examiner]
US 20170265843A1 · Abe et al. · 2017 [cited by applicant]
US 20170311839A1 · Osman · 2017 [cited by applicant]
US 20180014812A1 · Patil et al. · 2018 [cited by applicant]
US 20190247016A1 · Upton et al. · 2019 [cited by applicant]
US 20240208341A1 · Ogasawara · 2024 [cited by examiner]
CN 1914617A · 2007 [cited by applicant]
CN 102088913A · 2011 [cited by applicant]
CN 103505244A · 2014 [cited by applicant]
EP 1522875A1 · 2005 [cited by applicant]
GB 2505988A · 2014 [cited by applicant]
JP 2005237555A · 2005 [cited by applicant]
JP 2007526016A · 2007 [cited by applicant]
JP 2009207518A · 2009 [cited by applicant]
JP 2012081037A · 2012 [cited by applicant]
WO WO2005001769A2 · 2005 [cited by applicant]
WO WO2005081168A2 · 2005 [cited by applicant]
WO WO2007054861A2 · 2007 [cited by applicant]
WO WO2010004479A1 · 2010 [cited by applicant]
WO WO2015168792A1 · 2015 [cited by applicant]
WO WO2017069699A1 · 2017 [cited by applicant]
First Examination Report for Australian application No. 2017286613, mailed on Oct. 13, 2021, a counterpart foreign application of U.S. Appl. No. 17/179,252, 4 pages. [cited by applicant]
Translated the Chinese Office Action for corresponding Chinese Application No. 2017800419695, mailed on Nov. 28, 2022, a foreign counterpart to U.S. Appl. No. 17/179,252, 14 pages. [cited by applicant]
European communication issued Mar. 16, 2021, from corresponding EP Patent Application No. 17732542.0, 10 pages. [cited by applicant]
GB Search Report from corresponding GB Patent Application No. GB1610269.1, dated Dec. 19, 2016, 5 pages. [cited by applicant]
Gil et al., “Linking Myocardial Function and Structure through Tagged MRI and Diffusion Tensor Imaging,” International Society for Magnetic Resonance in Medicine, May 11, 2012 (May 11, 2012), XP040626271, 1 page. [cited by applicant]
First Examination Report for Indian application No. IN201817047167, mailed on Jun. 23, 2021, a counterpart foreign application of U.S. Appl. No. 17/179,252, 6 pages. [cited by applicant]
International Preliminary Report on Patentability from corresponding GB PCT Application No. PCT/GB2017/051720, dated Dec. 27, 2018, 20 pages. [cited by applicant]
International Search Report from corresponding GB PCT Application No. PCT/GB2017/051720, dated Aug. 14, 2017, 5 pages. [cited by applicant]
Translation of JP Rejection mailed Mar. 11, 2021, from corresponding JP Patent Application No. 2019-517180, 4 pages. [cited by applicant]
Korean Office Action mailed Dec. 24, 2021, from corresponding KR Patent Application No. 10-2019-700713, 6 pages. [cited by applicant]
First Examination Report for New Zealand application No. 749228, mailed on Aug. 23, 2021, a counterpart foreign application of U.S. Appl. No. 17/179,252, 5 pages. [cited by applicant]
Second Examination Report for New Zealand application No. 749228, mailed on Apr. 26, 2022, a counterpart foreign application of U.S. Appl. No. 17/179,252, 3 pages. [cited by applicant]
Office Action for U.S. Appl. No. 17/179,252, mailed on Mar. 31, 2023, Ross Upton, “Image-Based Diagnostic Systems”, 6 pages. [cited by applicant]
Office Action for U.S. Appl. No. 17/179,252, mailed on Nov. 17, 2022, Upton, “Image-Based Diagnostic Systems”, 15 pages. [cited by applicant]
Non Final Office Action dated Jun. 29, 2020 for U.S. Appl. No. 16/309,432 “Image-Based Diagnostic Systems” Upton, 15 pages. [cited by applicant]
First Written Opinion Report for Singaporean application No. 11201811125X, mailed on Mar. 31, 2020, a counterpart foreign application of U.S. Appl. No. 17/179,252, 6 pages. [cited by applicant]
Second Written Opinion Report for Singaporean application No. 11201811125X, mailed on Feb. 22, 2021, a counterpart foreign application of U.S. Appl. No. 17/179,252, 5 pages. [cited by applicant]
Third Written Opinion Report for Singaporean application No. 11201811125X, mailed on Jan. 19, 2022, a counterpart foreign application of U.S. Appl. No. 17/179,252, 6 pages. [cited by applicant]
Singapore Office Action mailed Dec. 12, 2022 for Signapore Application No. 11201811125X, a foreign counterpart to U.S. Appl. No. 17/179,252, 5 pages. [cited by applicant]
Steinhard et al., “OP18.11: Quantification of regional atrial contraction in the eftal heart using the parameters strain and velocity-a tissue Dopppler imaging (TDI) study,” Ultrasound in Obstetrics ADN Gynecology, vol.… [cited by applicant]
Anonymous, “Strain rate imaging—Wikipedia,” Aug. 11, 2015 (Aug. 11, 2015), XP55782308, Retrived from <<https://en.wikipedia.org/w/index.php?title=strain_rate_imagining&oldid=675532405>>, retrieved on Mar. 4, 2021, 8 pag… [cited by applicant]
Written Opinion from corresponding GB PCT Application No. PCT/GB2017/051720, dated Aug. 14, 2017, 6 pages. [cited by applicant]
European Examination Report Mailed Mar. 11, 2024 for European Patent Application No. 17732542.0-1210, a foreign counterpart to U.S. Appl. No. 18/524,838, 6 pages. [cited by applicant]