COMPRESSION EXERTION DEVICE
Embodiments of the present invention are directed to devices, systems and methods adapted for implementing intermittent displacement of blood to mitigate peripheral nerve neuropathy such as that induced by chemotherapeutic agents (i.e., chemotherapy-induced neuropathy (CIN)) that are administered to a patient. Such devices, systems and methods advantageously provide for precise, uniform and controlled blood flow occluding (and optionally blood displacing) compression along irregular surfaces of an appendage of a patient. Such precise, uniform and controlled blood occluding compression is imparted upon the epidermal and dermis skin layers within the aforementioned areas of a patient's extremities to decrease the time that free nerve endings located in the epidermal and encapsulated nerve endings located in the dermis skin layers are exposed to nerve damaging chemotherapy chemicals, thereby substantially decreasing CIN caused by prolonged exposure to such chemicals.
1 . (canceled)
2 . A compression exertion device, comprising:
a first body having an interior space and including an opening through which the interior space is accessed;
a second body within the interior space of the first enclosure, wherein the second body is attached to the first body such that the first body and the second body jointly define an expansion cavity adapted for having a compression-inducing medium provided therein, wherein the second body defines a body part receiving space at least partially encompassed by the expansion cavity and accessible through the opening, and wherein at least a portion of the second body is a substrate that permits at least one tissue-treating constituent component of the compression-inducing medium to pass therethrough.
3 . The compression exertion device of claim 2 wherein an entire portion of the second body is the substrate.
4 . The compression exertion device of claim 3 wherein the at least one tissue-treating constituent component one of consists of and comprises at least one of a thermally-conditioned constituent component, a constituent component that enhances penetration of oxygen into skin of the body part, and a constituent component one of consisting of oxygen and comprising oxygen.
5 . The compression exertion device of claim 3 wherein the substrate comprises a membrane.
6 . The compression exertion device of claim 2 wherein the at least one tissue-treating constituent component one of consists of and comprises at least one of a thermally-conditioned constituent component, a constituent component that enhances penetration of oxygen into skin of the body part, and a constituent component one of consisting of oxygen and comprising oxygen.
7 . The compression exertion device of claim 4 wherein the substrate comprises a membrane.
8 . The compression exertion device of claim 7 , further comprising:
at least one at least one of attached to and in functional contact with at least one of the first body and the second body, wherein the at least one sensor is operable to enable monitoring of blood oxygen within at least a portion of the body part.
9 . The compression exertion device of claim 2 wherein the substrate one of comprises a membrane and consists of a membrane.
10 . The compression exertion device of claim 2 wherein the substrate comprises passages for enabling transmission of at least the tissue-treating constituent component therethrough.
11 . The compression exertion device of claim 2 wherein the substrate enables oxygen diffusion therethrough.
12 . The compression exertion device of claim 11 wherein an entire portion of the second body is the substrate.
13 . The compression exertion device of claim 12 wherein the substrate one of comprises a membrane and consists of a membrane.
14 . The compression exertion device of claim 12 wherein the substrate comprises passages for enabling transmission of at least the tissue-treating constituent component therethrough.
15 . The compression exertion device of claim 2 , further comprising:
a body part engaging seal component extending around the opening and attached to at least one of the first body and the second body.
16 . The compression exertion device of claim 15 wherein an entire portion of the second body is the substrate.
17 . The compression exertion device of claim 15 wherein the at least one tissue-treating constituent component one of consists of and comprises at least one of a thermally-conditioned constituent component, a constituent component that enhances penetration of oxygen into skin of the body part, and a constituent component one of consisting of oxygen and comprising oxygen.
18 . The compression exertion device of claim 17 wherein the substrate comprises passages for enabling transmission of at least the tissue-treating constituent component therethrough.
19 . The compression exertion device of claim 15 wherein the substrate one of comprises a membrane and consists of a membrane.
20 . The compression exertion device of claim 19 wherein the at least one tissue-treating constituent component one of consists of and comprises at least one of a thermally-conditioned constituent component, a constituent component that enhances penetration of oxygen into skin of the body part, and a constituent component one of consisting of oxygen and comprising oxygen.
21 . The compression exertion device of claim 15 wherein the substrate comprises passages for enabling transmission of at least the tissue-treating constituent component therethrough.
22 . The compression exertion device of claim 15 wherein the substrate enables oxygen diffusion therethrough.
23 . The compression exertion device of claim 2 wherein the at least a portion of the second body is at a location of the second body to enabled delivery of the at least one tissue-treating constituent component to a targeted location of a body part disposed within the body part receiving space.
24 . The compression exertion device of claim 23 wherein the at least one tissue-treating constituent component one of consists of and comprises at least one of a thermally-conditioned constituent component, a constituent component that enhances penetration of oxygen into skin of the body part, and a constituent component one of consisting of oxygen and comprising oxygen.
25 . The compression exertion device of claim 23 wherein the substrate enables oxygen diffusion therethrough.
26 . The compression exertion device of claim 25 wherein the at least one tissue-treating constituent component one of consists of and comprises at least one of a thermally-conditioned constituent component, a constituent component that enhances penetration of oxygen into skin of the body part, and a constituent component one of consisting of oxygen and comprising oxygen.
27 . An article of manufacture operably used with a peripheral neuropathy mitigation apparatus during chemotherapy treatment to reduce adverse chemotherapy treatment outcomes associated with nerve endings within a skin layer of a body part arising from at least one of exposure of the nerve endings to the chemotherapy agent and compressive pressure induced deprivation of oxygen within the skin layer, the article comprising
an outer enclosure having a body part receiving space adapted for having a body part of a patient engaged therein, wherein the outer enclosure includes an opening through which the body part is placed into the body part receiving space;
at least one flow passage body engaged with the outer enclosure, wherein the at least one flow passage body includes a flow passage that is exposed to the body part receiving space to enable pressurized delivery of a compression inducing medium into the body part receiving space; and
a tissue-treating medium within the body part receiving space.
28 . The article of claim 26 , further comprising:
a body part engaging seal component extending at least partially around the opening and attached to the outer enclosure.
29 . The article of claim 27 wherein the tissue-treating medium one of consists of and comprises at least one of a thermally-conditioned constituent component, a constituent component that enhances penetration of oxygen into skin of the body part, and a constituent component one of consisting of oxygen and comprising oxygen.
30 . The article of claim 27 , further comprising:
an outer body at an exterior surface of the outer enclosure, wherein the outer body constrains expansion of the outer enclosure during said pressurized delivery of the compression inducing medium.
31 . The article of claim 30 , further comprising:
a body part engaging seal component extending around the opening and attached to at least one of the outer enclosure and the outer body.
32 . The article of claim 27 wherein the at least one tissue-treating medium is applied onto an interior surface of the outer enclosure.
33 . The article of claim 32 wherein the tissue-treating medium one of consists of and comprises at least one of a thermally-conditioned constituent component, a constituent component that enhances penetration of oxygen into skin of the body part, and a constituent component one of consisting of oxygen and comprising oxygen.
34 . The article of claim 32 , further comprising:
a substrate covering the tissue-treating medium, wherein substrate one of comprises and consists of a material that is impermeable to an active constituent component of the tissue-treating medium.
35 . The article of claim 34 wherein the tissue-treating medium one of consists of and comprises at least one of a thermally-conditioned constituent component, a constituent component that enhances penetration of oxygen into skin of the body part, and a constituent component one of consisting of oxygen and comprising oxygen.