Stress test and treatment of chronic kidney disease
The present invention involves a novel method for treatment of chronic kidney disease comprising administering a compound that induces a stress protein response in a patient, and administering a potent antioxidant if the patent's response is below a predefined level. It also involves a quantitative measure for determining a patient's antioxidant reserve capacity.
1. A method comprising:
(a) administering a compound to a patient, wherein the compound is a protoporphyrin or mesoporphyrin, which stimulates production of one or more antioxidant proteins in the patient;
(b) obtaining one or more body fluid samples from a patient; and
(c) measuring the level of the one or more anti-oxidant proteins produced in the patient.
2. The method of claim 1 , wherein the compound is a transient oxidant stress inducer.
3. The method of claim 1 , wherein compound is a metal protoporphyrin.
4. The method of claim 3 , wherein the metal protoporphyrin is tin, cobalt, or zinc protoporphyrin.
5. The method of claim 1 , wherein the anti-oxidant proteins comprise one or more of HO-1, ferritin, p21, or NQO1.
6. The method of claim 1 , wherein the level of production of the one or more anti-oxidant proteins is measured before step (a), and the level of expression of the one or more anti-oxidant proteins measured in step (c) is compared to the level of expression measured before step (a).
7. The method of claim 1 , wherein the measured level of antioxidant proteins provides a quantitative measure of the anti-oxidant reserves of the patient.