Pressurized nanoemulsion
The present invention relates to stabilizing an oil in water nanoemulsion in a pressurized container. The nanovesicles comprised in the nanoemulsion are particularly stable in regard to vesicle size and vesicle size homogeneity after long-term storage at different temperatures.
1. A formulation comprising:
(a) a nanoemulsion comprising:
(i) at least one aqueous component;
(ii) a carrier component comprising:
(1) at least one lipophilic component,
(2) at least one surfactant, and
(3) at least one alcohol; and
(b) a propellant,
wherein the formulation is comprised in a pressurized container;
wherein the formulation comprises less than 0.5% (w/w) based on the total weight of the formulation or no fatty alcohol;
wherein the formulation comprises an active agent;
wherein the active agent is 5-aminolevulinic acid, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable derivative thereof; and
wherein the pharmaceutically acceptable derivative thereof comprises esters, ethers, thioesters, methyl-thioesters, thioethers, methyl-thioethers methoxy-substituted benzyl ethers, silyl ethers, sulfonates, sulfenates, sulfinates, carbonates, cyclic carbonates, carbamates, cyclic acetals, cyclic ketals, ketones, chiral ketones, hydrazones, enamines and/or enols.
2. The formulation of claim 1 , wherein the formulation comprises less than 0.5% (w/w) based on the total weight of the formulation or no fatty acid.
3. The formulation of claim 2 , wherein the formulation comprises less than 0.5% (w/w) based on the total weight of the formulation or no gelling agent.
4. The formulation of claim 3 , wherein the formulation comprises less than 0.5% (w/w) based on the total weight of the formulation or no emollient selected from a monoester or diester comprising an alcohol and a fatty acid.
5. The formulation of claim 2 , wherein the formulation comprises a gelling agent, wherein the gelling agent is present in an amount of 0.1% to 10% (w/w) based on the total weight of the formulation.
6. The formulation of claim 5 , wherein the gelling agent is a poloxamer, wherein the poloxamer is present in an amount of 0.5% to 4% (w/w) based on the total weight of the formulation.
7. The formulation of claim 6 , wherein the at least one lipophilic component is present in an amount of 10% to 30% (w/w) based on the total weight of the nanoemulsion (a).
8. The formulation of claim 1 , wherein the nanoemulsion:
a. comprises nanovesicles having a size of less than or equal to 500 nm when stored one month, two months, three months, six months, or twelve months at 2-40° C., at 10-40° C., at 20-40° C., at 30-40° C., or at 40° C. in the pressurized container; and/or
b. is characterized by a polydispersity index of less than or equal to 0.4, when stored one month, two months, three months, six months, or twelve months, at 2-40° C., at 10-40° C., at 20-40° C., at 30-40° C., or at 40° C. in the pressurized container; and/or
c. comprises nanovesicles having a size of less than or equal to 500 nm when stored one month, two months, three months, six months, twelve months, eighteen months, or twenty-four months at 2-25° C., at 10-25° C., at 15-25° C., at 2-8° C., at 5° C. or at 25° C. in the pressurized container; and/or
d. comprises nanovesicles having a size of less than or equal to 500 nm when subjected to 1, 2, 3, 4, 5 or more freeze-thaw cycles; and/or
e. is characterized by a polydispersity index of less than or equal to 0.4, when stored one month, two months, three months, six months, twelve months, eighteen months, or twenty-four months at 2-25° C., at 10-25° C., at 15-25° C., at 2-8° C., at 5° C. or at 25° C. in the pressurized container; and/or
f. comprises nanovesicles having a size of less than or equal to 500 nm when stored one month, two months, three months, six months, twelve months, eighteen months, twenty-four months, thirty months, or thirty-six months at 2-8° C. or at 5° C. in the pressurized container; and/or
g. is characterized by a polydispersity index of less than or equal to 0.4, when stored one month, two months, three months, six months, twelve months, eighteen months, twenty-four months, thirty months, or thirty-six months, at 2-8° C. or at 5° C. in the pressurized container and/or
h. is characterized by a polydispersity index of less than or equal to 0.4, when subjected to 1, 2, 3, 4, 5 or more freeze-thaw cycles.
9. The formulation of claim 1 , wherein:
the at least one lipophilic component is selected from triglycerides and mixtures thereof;
the at least one surfactant comprises a phospholipid, a lysophospholipid, a ceramide, a mixture thereof, and/or a nonionic surfactant;
the at least one alcohol has 3-5 carbon atoms; and/or
the propellant is propane, isobutane, n-butane, or a mixture thereof.
10. The formulation of claim 1 , comprising a total aqueous component in an amount of 50% to 99% (w/w) based on the total weight of the nanoemulsion (a).
11. The formulation of claim 5 , wherein the gelling agent is selected from the group consisting of poloxamer, xanthan, bentonite, sodium carboxymethylcellulose, hydroxymethyl cellulose, carbomer, hydroxypropyl cellulose, gellan gum, guar gum, pectin, poly(ethylene)oxide, polycarbophil, alginate, tragacanth, povidone, gelatin, and mixtures thereof.
12. A container or a foam or spray dispenser product comprising a container, comprising the formulation of claim 1 .
13. A foam comprising the formulation of claim 1 .
14. A cosmetic comprising the formulation of claim 1 .
15. A formulation comprising:
(a) a nanoemulsion comprising:
(i) at least one aqueous component;
(ii) a carrier component comprising:
(1) at least one lipophilic component,
(2) at least one surfactant, and
(3) at least one alcohol; and
(b) a propellant,
wherein the formulation is comprised in a pressurized container,
wherein the formulation comprises less than 0.5% (w/w) based on the total weight of the formulation or no fatty alcohol,
wherein the formulation comprises a gelling agent, and
wherein the gelling agent is present in an amount of 0.1% to 10% (w/w) based on the total weight of the formulation.
16. The formulation of claim 15 , further comprising an active agent.
17. The formulation of claim 16 , wherein the active agent is 5-aminolevulinic acid, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable derivative thereof, wherein the pharmaceutically acceptable derivative comprises esters, ethers, thioesters, methyl-thioesters, thioethers, methyl-thioethers methoxy-substituted benzyl ethers, silyl ethers, sulfonates, sulfenates, sulfinates, carbonates, cyclic carbonates, carbamates, cyclic acetals, cyclic ketals, ketones, chiral ketones, hydrazones, enamines and/or enols.
18. A container or a foam or spray dispenser product comprising a container comprising the formulation of claim 15 .
19. A foam comprising the formulation of claim 15 .
20. A cosmetic comprising the formulation of claim 15 .
21. A formulation comprising:
(a) a nanoemulsion comprising:
(i) at least one aqueous component;
(ii) a carrier component comprising:
(1) at least one lipophilic component,
(2) at least one surfactant, and
(3) at least one alcohol; and
(b) a propellant,
wherein the formulation is comprised in a pressurized container,
wherein the formulation comprises less than 0.5% (w/w) fatty alcohol based on the total weight of the formulation or no fatty alcohol; and
wherein the formulation comprises an active agent, and
wherein the active agent is 5-aminolevulinic acid or a pharmaceutically acceptable salt or a pharmaceutically acceptable derivative thereof comprising an ester.