Heterocyclic GLP-1 agonists
This disclosure relates to GLP-1 agonists of Formula I: including pharmaceutically acceptable salts and solvates thereof, and pharmaceutical compositions including the same.
1 . A compound, or a pharmaceutically acceptable salt or solvate thereof, selected from the group consisting of:
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2 . A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable excipient.
3 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:
4 . A compound which is:
or a pharmaceutically acceptable salt thereof.
5 . A compound which is:
6 . A pharmaceutical composition comprising the compound of claim 4 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
7 . A compound which is:
or a pharmaceutically acceptable salt thereof.
8 . A compound which is:
9 . A pharmaceutical composition comprising the compound of claim 7 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
10 . A compound which is:
or a pharmaceutically acceptable salt thereof.
11 . A compound which is:
12 . A pharmaceutical composition comprising the compound of claim 10 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
13 . A compound which is:
or a pharmaceutically acceptable salt thereof.
14 . A compound which is:
15 . A pharmaceutical composition comprising the compound of claim 13 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
16 . A compound which is:
or a pharmaceutically acceptable salt thereof.
17 . A compound which is:
18 . A pharmaceutical composition comprising the compound of claim 16 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
19 . A compound which is:
or a pharmaceutically acceptable salt thereof.
20 . A compound which is:
21 . A pharmaceutical composition comprising the compound of claim 19 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.