SUBSTITUTED HETEROCYCLIC COMPOUNDS
There are disclosed compounds of the following formula I: or a stereoisomer or pharmaceutically acceptable salt thereof, wherein all substituents are as defined herein, which are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition. The compounds of the invention may be useful for treating neurodegenerative diseases or disorders.
1 . A method of treating a disease, comprising administering to a patient in need of such treatment, a therapeutically-effective amount of a compound of the formula
or a stereoisomer or pharmaceutically acceptable salt thereof, wherein
X is —N— or —CH—;
R 1 is —C(O)R 1a ;
R 1a is C 3-6 cycloalkyl;
R 2 is C 1-6 alkoxy;
R 3 is C 1-6 alkyl or C 3-6 cycloalkyl,
wherein the disease is a neurodegenerative disease selected from Alzheimer's disease, Parkinson's disease, ALS or Multiple Sclerosis.
2 . A method of treating a disease, comprising administering to a patient in need of such treatment, a therapeutically-effective amount of a compound or a pharmaceutically acceptable salt thereof, selected from
N-(4-((3-methoxy-4-(2-methyl-2H-1,2,3-triazol-4-yl)pyridin-2-yl)amino)-5-propionylpyridin-2-yl)cyclopropanecarboxamide,
N-(4-((3-methoxy-4-(2-cyclopropyl-2H-1,2,3-triazol-4-yl)pyridin-2-yl)amino)-5-propionylpyridin-2-yl)cyclopropanecarboxamide,
N-(4-((2-methoxy-3-(2-methyl-2H-1,2,3-triazol-4-yl)phenyl)amino)-5-propionylpyridin-2-yl)cyclopropanecarboxamide,
N-(4-((4-fluoro-2-methoxy-3-(2-methyl-2H-1,2,3-triazol-4-yl)phenyl)amino)-5-propionylpyridin-2-yl)cyclopropanecarboxamide,
N-(4-((3-fluoro-2-methoxy-3-(2-methyl-2H-1,2,3-triazol-4-yl)phenyl)amino)-5-propionylpyridin-2-yl)cyclopropanecarboxamide, and
N-(4-((3-methyl-2-methoxy-3-(2-methyl-2H-1,2,3-triazol-4-yl)phenyl)amino)-5-propionylpyridin-2-yl)cyclopropanecarboxamide,
wherein the disease is a neurodegenerative disease selected from Alzheimer's disease, Parkinson's disease, ALS or Multiple Sclerosis.