IP Library › Granted Patent US 12,246,180
Granted Patent B2
US 12,246,180 · App. 18/545,095 · Granted Mar 11, 2025

Methods and systems for controlling blood pressure by controlling atrial pressure

Inventors: Yuval Mika (Closter, NJ); Darren Sherman (Fort Lauderdale, FL); Robert S. Schwartz (Inver Grove Heights, MN); Robert A Van Tassel (Excelsior, MN); Daniel Burkhoff (Manhattan, NY)
Assignee: BackBeat Medical, LLC
A61N1/36564A61F2/2412A61F2/2424A61N1/36117A61N1/36514A61N1/36528A61N1/36571A61N1/36578A61N1/36585A61N1/3682A61N1/3684A61F2250/0013A61N1/36842A61N1/36843
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Quick Facts
Patent No.
US 12,246,180
App. No.
18/545,095
Granted
Mar 11, 2025
Kind
B2
Abstract

Systems and methods for controlling blood pressure by controlling atrial pressure and atrial stretch are disclosed. In some embodiments, a stimulation circuit may be configured to deliver a stimulation pulse to at least one cardiac chamber of a heart of a patient, and at least one controller may be configured to execute delivery of one or more stimulation patterns of stimulation pulses to the at least one cardiac chamber, wherein at least one of the stimulation pulses stimulates the heart such that an atrial pressure resulting from atrial contraction of an atrium overlaps in time a passive pressure build-up of the atrium, such that an atrial pressure of the atrium resulting from the stimulation is a combination of the atrial pressure resulting from atrial contraction and the passive pressure build-up and is higher than an atrial pressure of the atrium would be without the stimulation, and such that the blood pressure of the patient is reduced.

Claims (40)

1. A system for reducing ventricular filling volume in a patient having a pretreatment ventricular filling volume, comprising:

a stimulation circuit configured to deliver a stimulation pulse to at least one cardiac chamber of a heart of the patient; and

at least one controller configured to execute the delivery of one or more stimulation patterns of stimulation pulses to at least one cardiac chamber of the heart of the patient,

wherein at least one of the stimulation pulses reduces cardiac filling at an end of diastole, and

wherein at least one of the stimulation pulses is configured to pace the heart of the patient at a higher rate than the patient's natural rhythm.

2. The system of claim 1 , wherein the higher rate of pacing is configured to maintain a desired cardiac output of the heart.

3. The system of claim 1 , wherein the higher rate of pacing is configured to compensate for a reduction in cardiac output associated with reduced ventricular filling volume of the at least one of the stimulation pulses that reduces cardiac filling at an end of diastole.

4. The system of claim 3 , wherein the system is configured with a rate response algorithm to control a heart rate of the heart of the patient as a response to changes in level of exercise, ventilation activity, and/or oxygen consumption.

5. The system of claim 1 , wherein the at least one of the stimulation pulses that reduces cardiac filling at an end of diastole reduces the ventricular filling volume from the pretreatment ventricular filling volume by reducing or preventing atrial kick.

6. The system of claim 1 , wherein the at least one of the stimulation pulses that reduces cardiac filling at an end of diastole has an atrioventricular delay of between about −50 ms to about 70 ms, to reduce or prevent atrial kick.

7. The system of claim 1 , wherein the at least one of the stimulation pulses that reduces cardiac filling at an end of diastole has an atrioventricular delay of about 0 ms to about 30 ms.

8. A method for reducing ventricular filling volume in a patient having a pretreatment ventricular filling volume, comprising:

delivering one or more stimulation patterns of stimulation pulses to at least one cardiac chamber of a heart of the patient,

wherein at least one of the stimulation pulses reduces cardiac filling at an end of diastole, and

wherein at least one of the stimulation pulses is configured to pace the heart of the patient at a higher rate than the patient's natural rhythm.

9. The method of claim 8 , wherein the higher rate of pacing is configured to maintain a desired cardiac output of the heart.

10. The method of claim 8 , wherein the higher rate of pacing is configured to compensate for a reduction in cardiac output associated with reduced ventricular filling volume of the at least one of the stimulation pulses that reduces cardiac filling at an end of diastole.

11. The method of claim 10 , further comprising controlling a heart rate of the heart of the patient as a response to changes in level of exercise, ventilation activity, and/or oxygen consumption.

12. The method of claim 8 , wherein the at least one of the stimulation pulses that reduces cardiac filling at an end of diastole reduces the ventricular filling volume from the pretreatment ventricular filling volume by reducing or preventing atrial kick.

13. The method of claim 8 , wherein the at least one of the stimulation pulses that reduces cardiac filling at an end of diastole has an atrioventricular delay of between about −50 ms to about 70 ms, to reduce or prevent atrial kick.

14. The method of claim 8 , wherein the at least one of the stimulation pulses that reduces cardiac filling at an end of diastole has an atrioventricular delay of about 0 ms to about 30 ms.

15. A method for reducing ventricular filling volume in a patient having a pretreatment ventricular filling volume, comprising:

delivering one or more stimulation patterns of stimulation pulses to at least one cardiac chamber of a heart of the patient,

wherein at least one of the stimulation pulses has a first stimulation setting and at least one of the stimulation pulses has a second stimulation setting different from the first stimulation setting,

wherein the first stimulation setting is configured to reduce the ventricular filling volume from the pretreatment ventricular filling volume, and

wherein the second stimulation setting is configured to reduce or prevent adaptation associated with the first stimulation setting to maintain a desired cardiac output.

16. The method of claim 15 , wherein the second stimulation setting is configured to increase cardiac output.

17. The method of claim 15 , wherein the second stimulation setting is configured to reduce total peripheral resistance of the patient.

18. A method for reducing ventricular filling volume in a patient having a pretreatment ventricular filling volume, comprising:

delivering one or more stimulation patterns of stimulation pulses to at least one cardiac chamber of a heart of the patient,

wherein at least one of the stimulation pulses has a first stimulation setting and at least one of the stimulation pulses has a second stimulation setting different from the first stimulation setting,

wherein the first stimulation setting is configured to reduce the ventricular filling volume from the pretreatment ventricular filling volume, and

wherein the second stimulation setting is configured to pace the heart of the patient with an atrial kick higher than an atrial kick of the first stimulation setting to maintain a desired cardiac output.

19. The method of claim 18 , wherein the atrial kick of the second stimulation setting comprises a full atrial kick.

20. The method of claim 18 , wherein the second stimulation setting is configured to increase cardiac output.

21. A method for reducing blood pressure of a patient, comprising:

delivering one or more stimulation patterns of stimulation pulses to at least one cardiac chamber of a heart of the patient,

wherein at least one of the stimulation pulses comprises an atrial contraction stimulation pulse configured to pace an atrium of the heart of the patient at an atrial rate that is greater than an intrinsic ventricular rate of the heart of the patient, and

wherein the atrial contraction stimulation pulse reduces the blood pressure of the patient.

22. The method of claim 21 , wherein the atrial contraction stimulation pulse is configured to stimulate the heart such that the atrium reaches an increased atrial pressure resulting from atrial contraction at a period of time overlapping a passive pressure increase in atrial pressure.

Assignments (4)
SECURITY INTEREST Recorded Aug 7, 2025
From: ORCHESTRA BIOMED HOLDINGS, INC.; ORCHESTRA BIOMED, INC.; BACKBEAT MEDICAL, LLC; CALIBER THERAPEUTICS, LLC
To: MEDTRONIC, INC.
Reel/Frame 072341/0075 →
SECURITY INTEREST Recorded Aug 4, 2025
From: ORCHESTRA BIOMED HOLDINGS, INC.; ORCHESTRA BIOMED, INC.; BACKBEAT MEDICAL, LLC; CALIBER THERAPEUTICS, LLC
To: LIGAND PHARMACEUTICALS, INC.
Reel/Frame 072359/0219 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 16, 2024
From: MIKA, YUVAL; SHERMAN, DARREN; SCHWARTZ, ROBERT S.; VAN TASSEL, ROBERT A.; BURKHOFF, DANIEL
To: BACKBEAT MEDICAL, INC.
Reel/Frame 066135/0534 →
ENTITY CONVERSION Recorded Jan 16, 2024
From: BACKBEAT MEDICAL, INC.
To: BACKBEAT MEDICAL, LLC
Reel/Frame 066335/0949 →
Priority Claims (1)
WO PCT/US2013/076600 · Dec 19, 2013 · international
Continuity (8)
Continuation 18334436 · Jun 14, 2023
Continuation 17205114 · Mar 18, 2021
Continuation 16276958 · Feb 15, 2019
Continuation 15851787 · Dec 22, 2017
Continuation 15372603 · Dec 8, 2016
Continuation 14667931 · Mar 25, 2015
Division 14427478
Related Publication 20240173553A1 · May 30, 2024
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