FIXED DOSE COMBINATIONS AND FORMULATIONS COMPRISING ETC1002 AND EZETIMIBE AND METHODS OF TREATING OR REDUCING THE RISK OF CARDIOVASCULAR DISEASE
Disclosed herein are compositions comprising fixed doses of ETC-1002 and Ezetimibe. Also disclosed herein are methods for using fixed doses of ETC-1002 and Ezetimibe. Uses include methods of treating cardiovascular disease or reducing the risk of cardiovascular disease in a subject. Uses also include methods of treating hypercholesterolemia in a subject.
1 - 15 . (canceled)
16 . A method of preventing or reducing the risk of myocardial infarction in a subject with cardiovascular disease or at risk of cardiovascular disease, the method comprising administering daily to the subject 180 mg 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid and 10 mg ezetimibe.
17 . The method of claim 16 , wherein the subject has cardiovascular disease.
18 . The method of claim 16 , wherein the subject does not have cardiovascular disease.
19 . The method of claim 16 , wherein the 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid and ezetimibe are administered to the subject as a fixed-dose combination.
20 . The method of claim 19 , wherein the fixed-dose combination of 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid and ezetimibe is formulated to be a tablet.
21 . The method of claim 16 , wherein the 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid and ezetimibe are administered once daily to the subject.
22 . The method of claim 16 , wherein the subject is human.