COMPOUNDS AND COMPOSITIONS AND USES THEREOF

1 - 74 . (canceled)

75 . A compound of formula (I):

or a pharmaceutically acceptable salt thereof,

wherein:

Y is a direct bond;

R 1 , R 2 , R 3 and R 4 are chosen independently from H, aliphatic (C 1 -C 8 )hydrocarbon and (C 3 -C 6 )cycloalkyl, wherein the aliphatic (C 1 -C 8 )hydrocarbon is optionally substituted with one or more of halogen, hydroxyl, (C 1 -C 6 )alkoxy, amino, (C 1 -C 6 )alkylamino and di(C 1 -C 6 )alkylamino;

or, taken together, R 1 and R 2 may form (C 3 -C 6 )cycloalkyl;

R 9 and R 10 are chosen independently from H, halogen, hydroxyl, (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl and (C 1 -C 6 )alkoxy; and

R 11 , R 12 , R 13 , and R 14 are chosen independently from H, halogen, hydroxyl, cyano, aliphatic (C 1 -C 8 )hydrocarbon, (C 3 -C 6 )cycloalkyl, (C 1 -C 6 )haloalkyl, (C 1 -C 6 )alkoxy, aminocarbonyl, (C 1 -C 6 )alkylaminocarbonyl, di(C 1 -C 6 )alkylaminocarbonyl, (C 1 -C 6 )acyl, (C 1 -C 6 )haloalkoxy, hydroxy(C 1 -C 6 )alkyl, carboxy, (C 1 -C 6 )alkoxycarbonyl, acetoxy, nitro, amino, (C 1 -C 6 )alkylamino, di(C 1 -C 6 )alkylamino, and aminosulfonyl;

or, taken together, any adjacent pair of R 11 , R 12 , R 13 , and R 14 may form a fused 1,3-dioxole, dihydro-1,4-dioxine, difluoro-1,3-dioxole, 2,3-dihydrofuran optionally mono- or bisubstituted with fluorine, or 2,5-dihydrofuran optionally mono- or bi-substituted with fluorine.

76 . The compound according to claim 75 , wherein R 1 is hydrogen and R 2 is hydrogen or methyl; or wherein R 3 is hydrogen and R 4 is hydrogen or methyl.

77 . The compound according to claim 75 , wherein R 9 and R 10 are chosen independently from H, fluoro, and methyl.

78 . The compound according to claim 75 , wherein one of R 11 , R 12 , R 13 , and R 14 is fluoro, chloro, methyl or cyano and the remaining three are H.

79 . The compound according to claim 75 , wherein two of R 11 , R 12 , R 13 , and R 14 form a fused 1,3-dioxole or a fused dihydro-1,4-dioxine and the remaining two are H.

80 . The compound according to claim 75 , wherein R 1 is hydrogen; R 2 is hydrogen or methyl; R 3 is hydrogen; R 4 is hydrogen or methyl; and R 9 and R 10 are hydrogen.

81 . The compound according to claim 75 , of formula:

or a pharmaceutically acceptable salt thereof; or of formula:

or a pharmaceutically acceptable salt thereof.

82 . The composition, comprising the compound according to claim 75 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant, or vehicle.

83 . A method for treating a neurological or psychiatric disease or disorder in a subject in need thereof, comprising administering to said subject an effective amount of the compound according to claim 75 or a pharmaceutically acceptable salt thereof.

84 . The method for treating neuropsychiatric and behavior symptoms in a neurological disease or disorder in a subject, comprising administering to said subject an effective amount of the compound according to claim 75 .

85 . A compound of formula (I):

or a pharmaceutically acceptable salt thereof,

wherein:

Y is —C(R 5 R 6 )C(R 7 R 8 )—;

R 1 , R 2 , R 3 and R 4 are chosen independently from H, aliphatic (C 1 -C 8 )hydrocarbon and (C 3 -C 6 )cycloalkyl, wherein the aliphatic (C 1 -C 8 )hydrocarbon is optionally substituted with one or more of halogen, hydroxyl, (C 1 -C 6 )alkoxy, amino, (C 1 -C 6 )alkylamino and di(C 1 -C 6 )alkylamino;

or, taken together, R 1 and R 2 may form (C 3 -C 6 )cycloalkyl;

R 5 and R 6 are chosen independently from H, fluorine, (C 1 -C 6 )alkyl and (C 1 -C 6 )haloalkyl;

R 7 , R 8 , R 9 and R 10 are chosen independently from H, halogen, hydroxyl, (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl and (C 1 -C 6 )alkoxy; and

R 11 , R 12 , R 13 , and R 14 are chosen independently from H, halogen, hydroxyl, cyano, aliphatic (C 1 -C 8 )hydrocarbon, (C 3 -C 6 )cycloalkyl, (C 1 -C 6 )haloalkyl, (C 1 -C 6 )alkoxy, aminocarbonyl, (C 1 -C 6 )alkylaminocarbonyl, di(C 1 -C 6 )alkylaminocarbonyl, (C 1 -C 6 )acyl, (C 1 -C 6 )haloalkoxy, hydroxy(C 1 -C 6 )alkyl, carboxy, (C 1 -C 6 )alkoxycarbonyl, acetoxy, nitro, amino, (C 1 -C 6 )alkylamino, di(C 1 -C 6 )alkylamino, and aminosulfonyl;

or, taken together, any adjacent pair of R 11 , R 12 , R 13 , and R 14 may form a fused 1,3-dioxole, dihydro-1,4-dioxine, difluoro-1,3-dioxole, 2,3-dihydrofuran optionally mono- or bisubstituted with fluorine, or 2,5-dihydrofuran optionally mono- or bi-substituted with fluorine.

86 . The compound according to claim 85 , wherein R 1 is hydrogen and R 2 is hydrogen or methyl; or wherein R 3 is hydrogen and R 4 is hydrogen or methyl.

87 . The compound according to claim 85 , wherein R 5 , R 6 , R 7 , and R 8 are hydrogen; and/or wherein R 9 and R 10 are chosen independently from H, fluoro, and methyl.

88 . The compound according to claim 85 , wherein one of R 11 , R 12 , R 13 , and R 14 is fluoro, chloro, methyl or cyano and the remaining three are H.

89 . The compound according to claim 85 , wherein two of R 11 , R 12 , R 13 , and R 14 form a fused 1,3-dioxole or a fused dihydro-1,4-dioxine and the remaining two are H.

90 . The compound according to claim 85 , wherein R 1 is hydrogen; R 2 is hydrogen or methyl; R 3 is hydrogen; R 4 is hydrogen or methyl; and R 9 and R 10 are hydrogen.

91 . The compound according to claim 85 , of formula:

or a pharmaceutically acceptable salt thereof; or of formula:

or a pharmaceutically acceptable salt thereof.

92 . The composition, comprising the compound according to claim 85 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant, or vehicle.

93 . A method for treating a neurological or psychiatric disease or disorder in a subject in need thereof, comprising administering to said subject an effective amount of the compound according to claim 85 or a pharmaceutically acceptable salt thereof.

94 . The method for treating neuropsychiatric and behavior symptoms in a neurological disease or disorder in a subject, comprising administering to said subject an effective amount of the compound according to claim 85 .