Granted Patent
B2
US 12,599,706 · App. 18/608,675 · Granted Apr 14, 2026
Adhesion prevention with shear-thinning polymeric hydrogels
Inventors:
Eric Andrew Appel (Stanford, CA); Y. Joseph Woo (Stanford, CA); Lyndsay Stapleton (Stanford, CA)
A61L31/041A61L31/042A61L31/145A61L31/148C08L1/08C08L67/025A61L2300/424A61L2400/06C08L2203/02C08L2205/22
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Abstract
A method of preventing tissue adhesion includes forming an incision in tissue, applying a hydrogel to tissue through the incision, and closing the incision with the hydrogel therein. The hydrogel includes a polymer non-covalently cross-linked with a plurality of nanoparticles and prevents a formation of adhesions between tissues and/or organs.
Claims (23)
1 . A method comprising:
applying a supramolecular hydrogel to a tissue after a surgical procedure performed on or proximate to the tissue, the supramolecular hydrogel comprising a hydrophobically modified cellulose derivative non-covalently cross-linked with a plurality of nanoparticles; and
inhibiting formation of an adhesion on the tissue with the applied supramolecular hydrogel.
2 . The method of claim 1 , wherein the supramolecular hydrogel comprises from 5 wt % to 10 wt % of the nanoparticles.
3 . The method of claim 1 , wherein the nanoparticles comprise poly(ethylene glycol)-block-poly(lactic acid) (PEG-PLA).
4 . The method of claim 1 , wherein the supramolecular hydrogel comprises from 1 wt % to 2 wt % of the hydrophobically modified cellulose derivative.
5 . The method of claim 1 , wherein the hydrophobically modified cellulose derivative comprises one or more of hydroxypropylmethylcellulose (HPMC), hydroxyethyl cellulose (HEC), hydroxypropylcellulose (HPC), ethylcellulose (EC), methylcellulose (MC), hydroxyethylmethylcellulose (HEMC), carboxymethylcellulose (CMC), or carboxymethyl ethyl cellulose (CMEC).
6 . The method of claim 1 , wherein the hydrophobically modified cellulose derivative is a cellulose derivative modified with a hydrophobic saturated alkyl moiety, a hydrophobic unsaturated alkyl moiety, or a hydrophobic aryl moiety.
7 . The method of claim 1 , wherein the supramolecular hydrogel is shear-thinning.
8 . The method of claim 1 , wherein the supramolecular hydrogel is self-healing.
9 . The method of claim 1 , wherein the supramolecular hydrogel is applied by injecting, spreading, or spraying.
10 . The method of claim 1 , wherein the tissue comprises one or more of abdominal tissue, orthopedic tissue, thoracic tissue, cardiac tissue, or gynecologic tissue.
11 . A method comprising:
administering a dynamically cross-linked hydrogel to a tissue after a surgical procedure performed on or proximate to the tissue to inhibit adhesion formation, the dynamically cross-linked hydrogel comprising non-covalent interactions between a hydrophobically modified cellulose derivative and a plurality of nanoparticles.
12 . The method of claim 11 , wherein the dynamically cross-linked hydrogel comprises from 5 wt % to 10 wt % of the nanoparticles.
13 . The method of claim 11 , wherein the nanoparticles comprise poly(ethylene glycol)-block-poly(lactic acid) (PEG-PLA).
14 . The method of claim 11 , wherein the dynamically cross-linked hydrogel comprises from 1 wt % to 2 wt % of the hydrophobically modified cellulose derivative.
15 . The method of claim 11 , wherein the hydrophobically modified cellulose derivative comprises one or more of hydroxypropylmethylcellulose (HPMC), hydroxyethyl cellulose (HEC), hydroxypropylcellulose (HPC), ethylcellulose (EC), methylcellulose (MC), hydroxyethylmethylcellulose (HEMC), carboxymethylcellulose (CMC), or carboxymethyl ethyl cellulose (CMEC).
16 . The method of claim 11 , wherein the hydrophobically modified cellulose derivative is a cellulose derivative modified with a hydrophobic saturated alkyl moiety, a hydrophobic unsaturated alkyl moiety, or a hydrophobic aryl moiety.
17 . The method of claim 11 , wherein the dynamically cross-linked hydrogel is shear-thinning.
18 . The method of claim 11 , wherein the dynamically cross-linked hydrogel is self-healing.
19 . The method of claim 11 , wherein the dynamically cross-linked hydrogel is administered by injecting, spreading, or spraying.
20 . The method of claim 11 , wherein the tissue comprises one or more of abdominal tissue, orthopedic tissue, thoracic tissue, cardiac tissue, or gynecologic tissue.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 18, 2024
From: APPEL, ERIC ANDREW; WOO, Y. JOSEPH; STAPLETON, LYNDSAY
To: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Reel/Frame 066815/0518 →
Continuity (5)
Provisional Application
62739550
· Oct 1, 2018
Provisional Application
62480636
· Apr 3, 2017
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